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Randomized Controlled Trial: Impact of Glycerin Suppositories on Time to Full Feeds in Preterm Infants

Background: Feed intolerance delays achievement of enteral feeding in preterm infants. Parenteral nutrition is associated with cholestasis and increased risk of sepsis. Glycerin suppositories have been used to promote gastrointestinal motility and feed tolerance. Objectives: To investigate whether d... Full description

Journal Title: Neonatology (Basel Switzerland), 2011, Vol.100 (2), p.169-176
Main Author: Khadr, Sophie N
Other Authors: Ibhanesebhor, Samuel E , Rennix, Connie , Fisher, Hazel E , Manjunatha, Chikkanayakanahalli M , Young, David , Abara, Rosemary C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 1661-7800
Link: https://www.ncbi.nlm.nih.gov/pubmed/21455007
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title: Randomized Controlled Trial: Impact of Glycerin Suppositories on Time to Full Feeds in Preterm Infants
format: Article
creator:
  • Khadr, Sophie N
  • Ibhanesebhor, Samuel E
  • Rennix, Connie
  • Fisher, Hazel E
  • Manjunatha, Chikkanayakanahalli M
  • Young, David
  • Abara, Rosemary C
subjects:
  • Dose-Response Relationship, Drug
  • Enteral Nutrition
  • Enterocolitis, Necrotizing - epidemiology
  • Feeding Behavior - drug effects
  • Feeding Behavior - physiology
  • Female
  • Gastrointestinal Motility - drug effects
  • Gastrointestinal Motility - physiology
  • Glycerol - administration & dosage
  • Glycerol - pharmacology
  • Humans
  • Incidence
  • Infant, Newborn
  • Infant, Premature - physiology
  • Male
  • Meconium - metabolism
  • Original Paper
  • Sepsis - epidemiology
  • Suppositories
  • Time Factors
  • Treatment Outcome
ispartof: Neonatology (Basel, Switzerland), 2011, Vol.100 (2), p.169-176
description: Background: Feed intolerance delays achievement of enteral feeding in preterm infants. Parenteral nutrition is associated with cholestasis and increased risk of sepsis. Glycerin suppositories have been used to promote gastrointestinal motility and feed tolerance. Objectives: To investigate whether daily glycerin suppositories (a) reduce the time to full enteral feeding in infants born at
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1661-7800
fulltext: fulltext
issn:
  • 1661-7800
  • 1661-7819
url: Link


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titleRandomized Controlled Trial: Impact of Glycerin Suppositories on Time to Full Feeds in Preterm Infants
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creatorKhadr, Sophie N ; Ibhanesebhor, Samuel E ; Rennix, Connie ; Fisher, Hazel E ; Manjunatha, Chikkanayakanahalli M ; Young, David ; Abara, Rosemary C
creatorcontribKhadr, Sophie N ; Ibhanesebhor, Samuel E ; Rennix, Connie ; Fisher, Hazel E ; Manjunatha, Chikkanayakanahalli M ; Young, David ; Abara, Rosemary C
descriptionBackground: Feed intolerance delays achievement of enteral feeding in preterm infants. Parenteral nutrition is associated with cholestasis and increased risk of sepsis. Glycerin suppositories have been used to promote gastrointestinal motility and feed tolerance. Objectives: To investigate whether daily glycerin suppositories (a) reduce the time to full enteral feeding in infants born at <32 weeks’ gestation, and (b) influence feed tolerance, incidence of sepsis or necrotizing enterocolitis, duration of oxygen requirement, growth or age at discharge. Methods: Design – prospective open randomized controlled trial; study population – preterm infants stratified into 2 subgroups, 24–27+6 weeks (24–27 weeks + 6 days) and 28–31+6 weeks; intervention – daily glycerin suppository for 10 days from 24 h of age, 250 mg (24–27+6 weeks subgroup) or 500 mg (two 250-mg suppositories; 28–31+6 weeks subgroup); controls – no intervention. The same feeding protocol and departmental guidelines for other aspects of neonatal intensive care were used in all subjects. Analysis was by intention to treat. Results: 54 babies were recruited (31 males), 29 randomized to receive suppositories; 48 achieved full enteral feeds. The median (range) time to full feeds was 1.6 days shorter in intervention group babies than controls, but not statistically significant: 7.4 (4.6–30.9) days versus 9.0 (4.4–13.3) days (p = 0.780; 95% confidence interval: –1.917, 2.166). No significant differences were observed in secondary outcomes. Intervention group babies passed their first stool earlier than controls (median: day 2 vs. day 4; p = 0.016). Conclusion: Regular glycerin suppositories did not reduce the time to full enteral feeds in infants born at <32 weeks’ gestation in our setting.
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subjectDose-Response Relationship, Drug ; Enteral Nutrition ; Enterocolitis, Necrotizing - epidemiology ; Feeding Behavior - drug effects ; Feeding Behavior - physiology ; Female ; Gastrointestinal Motility - drug effects ; Gastrointestinal Motility - physiology ; Glycerol - administration & dosage ; Glycerol - pharmacology ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature - physiology ; Male ; Meconium - metabolism ; Original Paper ; Sepsis - epidemiology ; Suppositories ; Time Factors ; Treatment Outcome
ispartofNeonatology (Basel, Switzerland), 2011, Vol.100 (2), p.169-176
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1Ibhanesebhor, Samuel E
2Rennix, Connie
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4Manjunatha, Chikkanayakanahalli M
5Young, David
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descriptionBackground: Feed intolerance delays achievement of enteral feeding in preterm infants. Parenteral nutrition is associated with cholestasis and increased risk of sepsis. Glycerin suppositories have been used to promote gastrointestinal motility and feed tolerance. Objectives: To investigate whether daily glycerin suppositories (a) reduce the time to full enteral feeding in infants born at <32 weeks’ gestation, and (b) influence feed tolerance, incidence of sepsis or necrotizing enterocolitis, duration of oxygen requirement, growth or age at discharge. Methods: Design – prospective open randomized controlled trial; study population – preterm infants stratified into 2 subgroups, 24–27+6 weeks (24–27 weeks + 6 days) and 28–31+6 weeks; intervention – daily glycerin suppository for 10 days from 24 h of age, 250 mg (24–27+6 weeks subgroup) or 500 mg (two 250-mg suppositories; 28–31+6 weeks subgroup); controls – no intervention. The same feeding protocol and departmental guidelines for other aspects of neonatal intensive care were used in all subjects. Analysis was by intention to treat. Results: 54 babies were recruited (31 males), 29 randomized to receive suppositories; 48 achieved full enteral feeds. The median (range) time to full feeds was 1.6 days shorter in intervention group babies than controls, but not statistically significant: 7.4 (4.6–30.9) days versus 9.0 (4.4–13.3) days (p = 0.780; 95% confidence interval: –1.917, 2.166). No significant differences were observed in secondary outcomes. Intervention group babies passed their first stool earlier than controls (median: day 2 vs. day 4; p = 0.016). Conclusion: Regular glycerin suppositories did not reduce the time to full enteral feeds in infants born at <32 weeks’ gestation in our setting.
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0Dose-Response Relationship, Drug
1Enteral Nutrition
2Enterocolitis, Necrotizing - epidemiology
3Feeding Behavior - drug effects
4Feeding Behavior - physiology
5Female
6Gastrointestinal Motility - drug effects
7Gastrointestinal Motility - physiology
8Glycerol - administration & dosage
9Glycerol - pharmacology
10Humans
11Incidence
12Infant, Newborn
13Infant, Premature - physiology
14Male
15Meconium - metabolism
16Original Paper
17Sepsis - epidemiology
18Suppositories
19Time Factors
20Treatment Outcome
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titleRandomized Controlled Trial: Impact of Glycerin Suppositories on Time to Full Feeds in Preterm Infants
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1Ibhanesebhor, Samuel E
2Rennix, Connie
3Fisher, Hazel E
4Manjunatha, Chikkanayakanahalli M
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jtitleNeonatology (Basel, Switzerland)
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abstractBackground: Feed intolerance delays achievement of enteral feeding in preterm infants. Parenteral nutrition is associated with cholestasis and increased risk of sepsis. Glycerin suppositories have been used to promote gastrointestinal motility and feed tolerance. Objectives: To investigate whether daily glycerin suppositories (a) reduce the time to full enteral feeding in infants born at <32 weeks’ gestation, and (b) influence feed tolerance, incidence of sepsis or necrotizing enterocolitis, duration of oxygen requirement, growth or age at discharge. Methods: Design – prospective open randomized controlled trial; study population – preterm infants stratified into 2 subgroups, 24–27+6 weeks (24–27 weeks + 6 days) and 28–31+6 weeks; intervention – daily glycerin suppository for 10 days from 24 h of age, 250 mg (24–27+6 weeks subgroup) or 500 mg (two 250-mg suppositories; 28–31+6 weeks subgroup); controls – no intervention. The same feeding protocol and departmental guidelines for other aspects of neonatal intensive care were used in all subjects. Analysis was by intention to treat. Results: 54 babies were recruited (31 males), 29 randomized to receive suppositories; 48 achieved full enteral feeds. The median (range) time to full feeds was 1.6 days shorter in intervention group babies than controls, but not statistically significant: 7.4 (4.6–30.9) days versus 9.0 (4.4–13.3) days (p = 0.780; 95% confidence interval: –1.917, 2.166). No significant differences were observed in secondary outcomes. Intervention group babies passed their first stool earlier than controls (median: day 2 vs. day 4; p = 0.016). Conclusion: Regular glycerin suppositories did not reduce the time to full enteral feeds in infants born at <32 weeks’ gestation in our setting.
copBasel, Switzerland
pubS. Karger AG
pmid21455007
doi10.1159/000323964
tpages8