A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study
| Journal Title: | DIABETOLOGIA 2011-08-26, Vol.54 (11), p.2755-2767 |
| Main Author: | de Mello, V. D. F |
| Other Authors: | Schwab, U , Kolehmainen, M , Koenig, W , Siloaho, M , Poutanen, K , Mykkänen, H , Uusitupa, M |
| Format: |
 Electronic Article
|
| Language: |
English |
| Subjects: | |
| Publisher: | Berlin/Heidelberg: Springer-Verlag |
| ID: | ISSN: 0012-186X |
| Zum Text: |
SendSend as email
Add to Book BagAdd to Book Bag
Staff View
| recordid: | cdi_pubmed_primary_21870174 |
| title: | A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study |
| format: | Article |
| creator: |
|
| subjects: |
|
| ispartof: | DIABETOLOGIA, 2011-08-26, Vol.54 (11), p.2755-2767 |
| description: | Aims/hypothesis Low-grade inflammation and endothelial dysfunction may play a role in the pathogenesis of type 2 diabetes and cardiovascular disease. We evaluated whether a diet high in fatty fish, bilberries and wholegrain products (Healthy Diet) improves biomarkers reflecting inflammation and endothelial dysfunction in individuals with impaired glucose metabolism. Methods We recruited individuals with impaired glucose metabolism and features of the metabolic syndrome into a 12 week, parallel design, dietary intervention trial conducted at the Department of Clinical Nutrition, University of Eastern Finland (Kuopio, Finland). Randomisation was performed by matching according to sex and medians of age, BMI and fasting plasma glucose of the study population at screening. The primary endpoint in the present study was the change in plasma inflammatory markers and the measurements were performed blinded to group assignment. High-sensitivity (hs) C-reactive protein (CRP) and E-selectin responses were also analysed separately in participants not using statins ( n = 76). Results Altogether, 131 individuals were assigned to either the Healthy Diet ( n = 44), a whole-grain-enriched diet (WGED) ( n = 42) or a control ( n = 45) diet, and 104 participants (mean ± SD: age 59 ± 7 years; BMI 31.1 ± 3.5 kg/m 2 ) who had completed the study, were analysed (Healthy Diet n = 36, WGED n = 34 and control diet n = 34). Plasma E-selectin decreased only in the Healthy Diet group. This occurred in all group participants ( p |
| language: | eng |
| source: | |
| identifier: | ISSN: 0012-186X |
| fulltext: | no_fulltext |
| issn: |
|
| url: | Link |
| @attributes |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PrimoNMBib |
|