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A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study

Aims/hypothesis Low-grade inflammation and endothelial dysfunction may play a role in the pathogenesis of type 2 diabetes and cardiovascular disease. We evaluated whether a diet high in fatty fish, bilberries and wholegrain products (Healthy Diet) improves biomarkers reflecting inflammation and endo... Full description

Journal Title: DIABETOLOGIA 2011-08-26, Vol.54 (11), p.2755-2767
Main Author: de Mello, V. D. F
Other Authors: Schwab, U , Kolehmainen, M , Koenig, W , Siloaho, M , Poutanen, K , Mykkänen, H , Uusitupa, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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recordid: cdi_pubmed_primary_21870174
title: A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study
format: Article
creator:
  • de Mello, V. D. F
  • Schwab, U
  • Kolehmainen, M
  • Koenig, W
  • Siloaho, M
  • Poutanen, K
  • Mykkänen, H
  • Uusitupa, M
subjects:
  • 0 Not Open Access
  • 3 fatty acids
  • A1 Refereed journal article
  • Aged
  • Animals
  • Article
  • Bilberries
  • Biological and medical sciences
  • Biomarkers - blood
  • Body Mass Index
  • C-reactive protein
  • C-Reactive Protein - analysis
  • Dextrose
  • Diabetes. Impaired glucose tolerance
  • diet
  • Dietary Fiber - administration & dosage
  • Dietary Fiber - analysis
  • E-Selectin - blood
  • Edible Grain - chemistry
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Endothelium
  • Endothelium, Vascular - immunology
  • Endothelium, Vascular - physiopathology
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fatty acids
  • Fatty Acids, Omega-3 - analysis
  • Fatty Acids, Omega-3 - therapeutic use
  • Female
  • Finland
  • Fishes
  • Fruit
  • Glucose
  • glucose intolerance
  • Glucose Metabolism Disorders - blood
  • Glucose Metabolism Disorders - diet therapy
  • Glucose Metabolism Disorders - immunology
  • Glucose Metabolism Disorders - physiopathology
  • Human Physiology
  • Humans
  • Inflammation
  • Internal Medicine
  • intervention studies
  • Male
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • metabolic syndrome
  • Metabolic Syndrome - blood
  • Metabolic Syndrome - diet therapy
  • Metabolic Syndrome - immunology
  • Metabolic Syndrome - physiopathology
  • Middle Aged
  • minedu
  • Miscellaneous
  • openaccess
  • Other metabolic disorders
  • Physiological aspects
  • publicationtypes
  • Seafood - analysis
  • selectin
  • Statins
  • Type 2 diabetes
  • Vaccinium myrtillus
  • virta
  • whole grain
ispartof: DIABETOLOGIA, 2011-08-26, Vol.54 (11), p.2755-2767
description: Aims/hypothesis Low-grade inflammation and endothelial dysfunction may play a role in the pathogenesis of type 2 diabetes and cardiovascular disease. We evaluated whether a diet high in fatty fish, bilberries and wholegrain products (Healthy Diet) improves biomarkers reflecting inflammation and endothelial dysfunction in individuals with impaired glucose metabolism. Methods We recruited individuals with impaired glucose metabolism and features of the metabolic syndrome into a 12 week, parallel design, dietary intervention trial conducted at the Department of Clinical Nutrition, University of Eastern Finland (Kuopio, Finland). Randomisation was performed by matching according to sex and medians of age, BMI and fasting plasma glucose of the study population at screening. The primary endpoint in the present study was the change in plasma inflammatory markers and the measurements were performed blinded to group assignment. High-sensitivity (hs) C-reactive protein (CRP) and E-selectin responses were also analysed separately in participants not using statins ( n  = 76). Results Altogether, 131 individuals were assigned to either the Healthy Diet ( n  = 44), a whole-grain-enriched diet (WGED) ( n  = 42) or a control ( n  = 45) diet, and 104 participants (mean ± SD: age 59 ± 7 years; BMI 31.1 ± 3.5 kg/m 2 ) who had completed the study, were analysed (Healthy Diet n  = 36, WGED n  = 34 and control diet n  = 34). Plasma E-selectin decreased only in the Healthy Diet group. This occurred in all group participants ( p  
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleA diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study
creatorde Mello, V. D. F ; Schwab, U ; Kolehmainen, M ; Koenig, W ; Siloaho, M ; Poutanen, K ; Mykkänen, H ; Uusitupa, M
creatorcontribde Mello, V. D. F ; Schwab, U ; Kolehmainen, M ; Koenig, W ; Siloaho, M ; Poutanen, K ; Mykkänen, H ; Uusitupa, M
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languageeng
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subject0 Not Open Access ; 3 fatty acids ; A1 Refereed journal article ; Aged ; Animals ; Article ; Bilberries ; Biological and medical sciences ; Biomarkers - blood ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - analysis ; Dextrose ; Diabetes. Impaired glucose tolerance ; diet ; Dietary Fiber - administration & dosage ; Dietary Fiber - analysis ; E-Selectin - blood ; Edible Grain - chemistry ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium ; Endothelium, Vascular - immunology ; Endothelium, Vascular - physiopathology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acids ; Fatty Acids, Omega-3 - analysis ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Finland ; Fishes ; Fruit ; Glucose ; glucose intolerance ; Glucose Metabolism Disorders - blood ; Glucose Metabolism Disorders - diet therapy ; Glucose Metabolism Disorders - immunology ; Glucose Metabolism Disorders - physiopathology ; Human Physiology ; Humans ; Inflammation ; Internal Medicine ; intervention studies ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - diet therapy ; Metabolic Syndrome - immunology ; Metabolic Syndrome - physiopathology ; Middle Aged ; minedu ; Miscellaneous ; openaccess ; Other metabolic disorders ; Physiological aspects ; publicationtypes ; Seafood - analysis ; selectin ; Statins ; Type 2 diabetes ; Vaccinium myrtillus ; virta ; whole grain
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titleA diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: The Sysdimet study
authorde Mello, V. D. F ; Schwab, U ; Kolehmainen, M ; Koenig, W ; Siloaho, M ; Poutanen, K ; Mykkänen, H ; Uusitupa, M
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13 fatty acids
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4Animals
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9Body Mass Index
10C-reactive protein
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12Dextrose
13Diabetes. Impaired glucose tolerance
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15Dietary Fiber - administration & dosage
16Dietary Fiber - analysis
17E-Selectin - blood
18Edible Grain - chemistry
19Endocrine pancreas. Apud cells (diseases)
20Endocrinopathies
21Endothelium
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27Fatty Acids, Omega-3 - therapeutic use
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29Finland
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65virta
66whole grain
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