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Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis

Refractory psychosis units currently have little information regarding which symptoms profiles should be expected to respond to treatment. In the current study, we provide this information using structural equation modeling of Positive and Negative Syndrome Scale (PANSS) ratings at admission and dis... Full description

Journal Title: European archives of psychiatry and clinical neuroscience 2014, Vol.264 (8), p.673-682
Main Author: Woodward, T.S
Other Authors: Jung, K , Smith, G.N , Hwang, H , Barr, A.M , Procyshyn, R.M , Flynn, S.W , van der Gaag, M , Honer, W.G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0940-1334
Link: https://www.ncbi.nlm.nih.gov/pubmed/24126470
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recordid: cdi_pubmed_primary_24126470
title: Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis
format: Article
creator:
  • Woodward, T.S
  • Jung, K
  • Smith, G.N
  • Hwang, H
  • Barr, A.M
  • Procyshyn, R.M
  • Flynn, S.W
  • van der Gaag, M
  • Honer, W.G
subjects:
  • Adolescent
  • Adult
  • Aged
  • Analysis
  • Behavioral health care
  • Bipolar disorder
  • Bipolar Disorder - diagnosis
  • Bipolar Disorder - therapy
  • Canada
  • Depression, Mental
  • Depressive Disorder, Major - diagnosis
  • Depressive Disorder, Major - therapy
  • Female
  • Humans
  • Male
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Models, Statistical
  • Neurosciences
  • Original Paper
  • Psychiatric Status Rating Scales
  • Psychiatry
  • Psychotic Disorders - diagnosis
  • Psychotic Disorders - therapy
  • Schizophrenia
  • Schizophrenia - diagnosis
  • Schizophrenia - therapy
  • Severity of Illness Index
  • Treatment Outcome
  • Young Adult
ispartof: European archives of psychiatry and clinical neuroscience, 2014, Vol.264 (8), p.673-682
description: Refractory psychosis units currently have little information regarding which symptoms profiles should be expected to respond to treatment. In the current study, we provide this information using structural equation modeling of Positive and Negative Syndrome Scale (PANSS) ratings at admission and discharge on a sample of 610 patients admitted to a treatment refractory psychosis program at a Canadian tertiary care unit between 1990 and 2011. The hypothesized five-dimensional structure of the PANSS fit the data well at both admission and discharge, and the latent variable scores are reported as a function of symptom dimension and diagnostic category. The results suggest that, overall, positive symptoms (POS) responded to treatment better than all other symptoms dimensions, but for the schizoaffective and bipolar groups, greater response on POS was observed relative to the schizophrenia and major depression groups. The major depression group showed the most improvement on negative symptoms and emotional distress, and the bipolar group showed the most improvement on disorganization. Schizophrenia was distinct from schizoaffective disorder in showing reduced treatment response on all symptom dimensions. These results can assist refractory psychosis units by providing information on how PANSS symptom dimensions respond to treatment and how this depends on diagnostic category.
language: eng
source:
identifier: ISSN: 0940-1334
fulltext: no_fulltext
issn:
  • 0940-1334
  • 1433-8491
url: Link


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titleSymptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis
creatorWoodward, T.S ; Jung, K ; Smith, G.N ; Hwang, H ; Barr, A.M ; Procyshyn, R.M ; Flynn, S.W ; van der Gaag, M ; Honer, W.G
creatorcontribWoodward, T.S ; Jung, K ; Smith, G.N ; Hwang, H ; Barr, A.M ; Procyshyn, R.M ; Flynn, S.W ; van der Gaag, M ; Honer, W.G
descriptionRefractory psychosis units currently have little information regarding which symptoms profiles should be expected to respond to treatment. In the current study, we provide this information using structural equation modeling of Positive and Negative Syndrome Scale (PANSS) ratings at admission and discharge on a sample of 610 patients admitted to a treatment refractory psychosis program at a Canadian tertiary care unit between 1990 and 2011. The hypothesized five-dimensional structure of the PANSS fit the data well at both admission and discharge, and the latent variable scores are reported as a function of symptom dimension and diagnostic category. The results suggest that, overall, positive symptoms (POS) responded to treatment better than all other symptoms dimensions, but for the schizoaffective and bipolar groups, greater response on POS was observed relative to the schizophrenia and major depression groups. The major depression group showed the most improvement on negative symptoms and emotional distress, and the bipolar group showed the most improvement on disorganization. Schizophrenia was distinct from schizoaffective disorder in showing reduced treatment response on all symptom dimensions. These results can assist refractory psychosis units by providing information on how PANSS symptom dimensions respond to treatment and how this depends on diagnostic category.
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subjectAdolescent ; Adult ; Aged ; Analysis ; Behavioral health care ; Bipolar disorder ; Bipolar Disorder - diagnosis ; Bipolar Disorder - therapy ; Canada ; Depression, Mental ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - therapy ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Models, Statistical ; Neurosciences ; Original Paper ; Psychiatric Status Rating Scales ; Psychiatry ; Psychotic Disorders - diagnosis ; Psychotic Disorders - therapy ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - therapy ; Severity of Illness Index ; Treatment Outcome ; Young Adult
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descriptionRefractory psychosis units currently have little information regarding which symptoms profiles should be expected to respond to treatment. In the current study, we provide this information using structural equation modeling of Positive and Negative Syndrome Scale (PANSS) ratings at admission and discharge on a sample of 610 patients admitted to a treatment refractory psychosis program at a Canadian tertiary care unit between 1990 and 2011. The hypothesized five-dimensional structure of the PANSS fit the data well at both admission and discharge, and the latent variable scores are reported as a function of symptom dimension and diagnostic category. The results suggest that, overall, positive symptoms (POS) responded to treatment better than all other symptoms dimensions, but for the schizoaffective and bipolar groups, greater response on POS was observed relative to the schizophrenia and major depression groups. The major depression group showed the most improvement on negative symptoms and emotional distress, and the bipolar group showed the most improvement on disorganization. Schizophrenia was distinct from schizoaffective disorder in showing reduced treatment response on all symptom dimensions. These results can assist refractory psychosis units by providing information on how PANSS symptom dimensions respond to treatment and how this depends on diagnostic category.
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titleSymptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis
authorWoodward, T.S ; Jung, K ; Smith, G.N ; Hwang, H ; Barr, A.M ; Procyshyn, R.M ; Flynn, S.W ; van der Gaag, M ; Honer, W.G
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abstractRefractory psychosis units currently have little information regarding which symptoms profiles should be expected to respond to treatment. In the current study, we provide this information using structural equation modeling of Positive and Negative Syndrome Scale (PANSS) ratings at admission and discharge on a sample of 610 patients admitted to a treatment refractory psychosis program at a Canadian tertiary care unit between 1990 and 2011. The hypothesized five-dimensional structure of the PANSS fit the data well at both admission and discharge, and the latent variable scores are reported as a function of symptom dimension and diagnostic category. The results suggest that, overall, positive symptoms (POS) responded to treatment better than all other symptoms dimensions, but for the schizoaffective and bipolar groups, greater response on POS was observed relative to the schizophrenia and major depression groups. The major depression group showed the most improvement on negative symptoms and emotional distress, and the bipolar group showed the most improvement on disorganization. Schizophrenia was distinct from schizoaffective disorder in showing reduced treatment response on all symptom dimensions. These results can assist refractory psychosis units by providing information on how PANSS symptom dimensions respond to treatment and how this depends on diagnostic category.
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pmid24126470
doi10.1007/s00406-013-0460-x