schliessen

Filtern

 

Bibliotheken

Rapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies

Background and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined underlying explanatory mechanism. We aimed at more reliably quantifying the bene... Full description

Journal Title: Cerebrovascular diseases (Basel Switzerland), 2015-04, Vol.39 (3-4), p.242-248
Main Author: Wang, Xia
Other Authors: Arima, Hisatomi , Al-Shahi Salman, Rustam , Woodward, Mark , Heeley, Emma , Stapf, Christian , Lavados, Pablo M , Robinson, Thompson , Huang, Yining , Wang, Jiguang , Delcourt, Candice , Anderson, Craig S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 1015-9770
Link: https://www.ncbi.nlm.nih.gov/pubmed/25823544
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmed_primary_25823544
title: Rapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies
format: Article
creator:
  • Wang, Xia
  • Arima, Hisatomi
  • Al-Shahi Salman, Rustam
  • Woodward, Mark
  • Heeley, Emma
  • Stapf, Christian
  • Lavados, Pablo M
  • Robinson, Thompson
  • Huang, Yining
  • Wang, Jiguang
  • Delcourt, Candice
  • Anderson, Craig S
subjects:
  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis
  • Blood pressure
  • Blood Pressure - physiology
  • Cerebral Hemorrhage - complications
  • Cerebral Hemorrhage - therapy
  • Female
  • Humans
  • Hypotension - etiology
  • Hypotension - physiopathology
  • Intracerebral hemorrhage
  • Male
  • Middle Aged
  • Original Paper
  • Time Factors
  • Treatment Outcome
ispartof: Cerebrovascular diseases (Basel, Switzerland), 2015-04, Vol.39 (3-4), p.242-248
description: Background and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined underlying explanatory mechanism. We aimed at more reliably quantifying the benefits of this treatment according to different time periods in the recovery of participants in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) studies. Methods: Pooled analysis of the pilot INTERACT1 (n = 404) and main INTERACT2 (n = 2,839) involving patients with spontaneous ICH (
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1015-9770
fulltext: fulltext
issn:
  • 1015-9770
  • 1421-9786
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.4561937
LOCALfalse
PrimoNMBib
record
control
sourceidgale_cross
recordidTN_cdi_pubmed_primary_25823544
sourceformatXML
sourcesystemPC
galeidA636992162
sourcerecordidA636992162
originalsourceidFETCH-LOGICAL-1499t-eba1b683fecf87cbeae50cb4a9d98806bd6cdb219cb9f1654bd242a0703b0c93
addsrcrecordideNqNks1uEzEUhUeIipbCghdAXiFASmvPj8fubkgDrRRBFWY_8s91apgZB9tTlIfhXXFIm0XFovLCR1ffObq-11n2huAzQip-jjEuGCG4fpadkDInM14z-jxpTKqka3ycvQzhR8IoYeRFdpxXLC-qsjzJ_qzExmr0qXdOoxsPIUwe0NL9Bm_HNWqUcl7vVHRoBcrdgd8iEdGlNQY8jBG1dgB0PUbwd6IPSJikkm-K_6peqIRJL3p0BYPz_las4QLdONeDRs0o-m2wATmD4m0yfG0Xq2beou9x0hbCq-zIpFB4fX-fZu3nRTu_mi2_fbmeN8sZKTmPM5CCSMoKA8qwWkkQUGElS8E1ZwxTqanSMidcSW4IrUqp8zIXuMaFxIoXp9n7fezGu18ThNgNNijoezGCm0JHaF0zVuKaJPRsj65FD50djds9MR0Ng1VuBGNTvaEF5TwnNE-GD3uD8i4ED6bbeDsIv-0I7nbb6w7bS-zb-z4mOYA-kA_rSsD5ozBlo4jW7QZt-_9Gvts7fgq_Bn-InC8u8_Q7cMGLrkzDSODHJ4HdRpviLxPpvkM
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1677884071
display
typearticle
titleRapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies
sourceAlma/SFX Local Collection
creatorWang, Xia ; Arima, Hisatomi ; Al-Shahi Salman, Rustam ; Woodward, Mark ; Heeley, Emma ; Stapf, Christian ; Lavados, Pablo M ; Robinson, Thompson ; Huang, Yining ; Wang, Jiguang ; Delcourt, Candice ; Anderson, Craig S
creatorcontribWang, Xia ; Arima, Hisatomi ; Al-Shahi Salman, Rustam ; Woodward, Mark ; Heeley, Emma ; Stapf, Christian ; Lavados, Pablo M ; Robinson, Thompson ; Huang, Yining ; Wang, Jiguang ; Delcourt, Candice ; Anderson, Craig S ; for the INTERACT Investigators
descriptionBackground and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined underlying explanatory mechanism. We aimed at more reliably quantifying the benefits of this treatment according to different time periods in the recovery of participants in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) studies. Methods: Pooled analysis of the pilot INTERACT1 (n = 404) and main INTERACT2 (n = 2,839) involving patients with spontaneous ICH (<6 h) and elevated systolic BP (SBP 150-220 mm Hg) who were randomized to intensive (target SBP <140 mm Hg) or guideline-recommended (target SBP <180 mm Hg) BP lowering treatment. Treatment effects were examined according to repeated measures analysis of an ordinal (‘shift') across all 7 levels of the modified Rankin Scale (mRS) assessed during follow-up at 7, 28, and 90 days, post-randomization. Clinical trial registration information: http://www.clinicaltrials.gov, NCT00226096 and NCT00716079. Results: Intensive BP lowering resulted in a significant favorable distribution of mRS scores for better functioning (odds ratio 1.13, 95% confidence interval 1.00-1.26; p = 0.042) over 7, 28 and 90 days, and the effect was consistency for early (7-28 days) and later (28-90 days) time periods (p homogeneity 0.353). Treatment effects were also consistent across several pre-specified patient characteristic subgroups, with trends favoring those randomized early, and with higher SBP and milder neurological severity at baseline. Conclusions: Intensive BP lowering provides beneficial effects on physical functioning that manifests consistently through the early and later phases of recovery from ICH.
identifier
0ISSN: 1015-9770
1EISSN: 1421-9786
2DOI: 10.1159/000381107
3PMID: 25823544
languageeng
publisherBasel, Switzerland: S. Karger AG
subjectAcute Disease ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Blood pressure ; Blood Pressure - physiology ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - therapy ; Female ; Humans ; Hypotension - etiology ; Hypotension - physiopathology ; Intracerebral hemorrhage ; Male ; Middle Aged ; Original Paper ; Time Factors ; Treatment Outcome
ispartofCerebrovascular diseases (Basel, Switzerland), 2015-04, Vol.39 (3-4), p.242-248
rights
02015 S. Karger AG, Basel
12015 S. Karger AG, Basel.
2COPYRIGHT 2015 S. Karger AG
lds50peer_reviewed
citedbyFETCH-LOGICAL-1499t-eba1b683fecf87cbeae50cb4a9d98806bd6cdb219cb9f1654bd242a0703b0c93
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25823544$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Wang, Xia
1Arima, Hisatomi
2Al-Shahi Salman, Rustam
3Woodward, Mark
4Heeley, Emma
5Stapf, Christian
6Lavados, Pablo M
7Robinson, Thompson
8Huang, Yining
9Wang, Jiguang
10Delcourt, Candice
11Anderson, Craig S
12for the INTERACT Investigators
title
0Rapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies
1Cerebrovascular diseases (Basel, Switzerland)
addtitleCerebrovasc Dis
descriptionBackground and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined underlying explanatory mechanism. We aimed at more reliably quantifying the benefits of this treatment according to different time periods in the recovery of participants in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) studies. Methods: Pooled analysis of the pilot INTERACT1 (n = 404) and main INTERACT2 (n = 2,839) involving patients with spontaneous ICH (<6 h) and elevated systolic BP (SBP 150-220 mm Hg) who were randomized to intensive (target SBP <140 mm Hg) or guideline-recommended (target SBP <180 mm Hg) BP lowering treatment. Treatment effects were examined according to repeated measures analysis of an ordinal (‘shift') across all 7 levels of the modified Rankin Scale (mRS) assessed during follow-up at 7, 28, and 90 days, post-randomization. Clinical trial registration information: http://www.clinicaltrials.gov, NCT00226096 and NCT00716079. Results: Intensive BP lowering resulted in a significant favorable distribution of mRS scores for better functioning (odds ratio 1.13, 95% confidence interval 1.00-1.26; p = 0.042) over 7, 28 and 90 days, and the effect was consistency for early (7-28 days) and later (28-90 days) time periods (p homogeneity 0.353). Treatment effects were also consistent across several pre-specified patient characteristic subgroups, with trends favoring those randomized early, and with higher SBP and milder neurological severity at baseline. Conclusions: Intensive BP lowering provides beneficial effects on physical functioning that manifests consistently through the early and later phases of recovery from ICH.
subject
0Acute Disease
1Adult
2Aged
3Aged, 80 and over
4Analysis
5Blood pressure
6Blood Pressure - physiology
7Cerebral Hemorrhage - complications
8Cerebral Hemorrhage - therapy
9Female
10Humans
11Hypotension - etiology
12Hypotension - physiopathology
13Intracerebral hemorrhage
14Male
15Middle Aged
16Original Paper
17Time Factors
18Treatment Outcome
issn
01015-9770
11421-9786
fulltexttrue
rsrctypearticle
creationdate2015
recordtypearticle
recordideNqNks1uEzEUhUeIipbCghdAXiFASmvPj8fubkgDrRRBFWY_8s91apgZB9tTlIfhXXFIm0XFovLCR1ffObq-11n2huAzQip-jjEuGCG4fpadkDInM14z-jxpTKqka3ycvQzhR8IoYeRFdpxXLC-qsjzJ_qzExmr0qXdOoxsPIUwe0NL9Bm_HNWqUcl7vVHRoBcrdgd8iEdGlNQY8jBG1dgB0PUbwd6IPSJikkm-K_6peqIRJL3p0BYPz_las4QLdONeDRs0o-m2wATmD4m0yfG0Xq2beou9x0hbCq-zIpFB4fX-fZu3nRTu_mi2_fbmeN8sZKTmPM5CCSMoKA8qwWkkQUGElS8E1ZwxTqanSMidcSW4IrUqp8zIXuMaFxIoXp9n7fezGu18ThNgNNijoezGCm0JHaF0zVuKaJPRsj65FD50djds9MR0Ng1VuBGNTvaEF5TwnNE-GD3uD8i4ED6bbeDsIv-0I7nbb6w7bS-zb-z4mOYA-kA_rSsD5ozBlo4jW7QZt-_9Gvts7fgq_Bn-InC8u8_Q7cMGLrkzDSODHJ4HdRpviLxPpvkM
startdate201504
enddate201504
creator
0Wang, Xia
1Arima, Hisatomi
2Al-Shahi Salman, Rustam
3Woodward, Mark
4Heeley, Emma
5Stapf, Christian
6Lavados, Pablo M
7Robinson, Thompson
8Huang, Yining
9Wang, Jiguang
10Delcourt, Candice
11Anderson, Craig S
generalS. Karger AG
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
87X8
sort
creationdate201504
titleRapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies
authorWang, Xia ; Arima, Hisatomi ; Al-Shahi Salman, Rustam ; Woodward, Mark ; Heeley, Emma ; Stapf, Christian ; Lavados, Pablo M ; Robinson, Thompson ; Huang, Yining ; Wang, Jiguang ; Delcourt, Candice ; Anderson, Craig S
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1499t-eba1b683fecf87cbeae50cb4a9d98806bd6cdb219cb9f1654bd242a0703b0c93
rsrctypearticles
prefilterarticles
languageeng
creationdate2015
topic
0Acute Disease
1Adult
2Aged
3Aged, 80 and over
4Analysis
5Blood pressure
6Blood Pressure - physiology
7Cerebral Hemorrhage - complications
8Cerebral Hemorrhage - therapy
9Female
10Humans
11Hypotension - etiology
12Hypotension - physiopathology
13Intracerebral hemorrhage
14Male
15Middle Aged
16Original Paper
17Time Factors
18Treatment Outcome
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Wang, Xia
1Arima, Hisatomi
2Al-Shahi Salman, Rustam
3Woodward, Mark
4Heeley, Emma
5Stapf, Christian
6Lavados, Pablo M
7Robinson, Thompson
8Huang, Yining
9Wang, Jiguang
10Delcourt, Candice
11Anderson, Craig S
12for the INTERACT Investigators
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7MEDLINE - Academic
jtitleCerebrovascular diseases (Basel, Switzerland)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Wang, Xia
1Arima, Hisatomi
2Al-Shahi Salman, Rustam
3Woodward, Mark
4Heeley, Emma
5Stapf, Christian
6Lavados, Pablo M
7Robinson, Thompson
8Huang, Yining
9Wang, Jiguang
10Delcourt, Candice
11Anderson, Craig S
aucorpfor the INTERACT Investigators
formatjournal
genrearticle
ristypeJOUR
atitleRapid Blood Pressure Lowering According to Recovery at Different Time Intervals after Acute Intracerebral Hemorrhage: Pooled Analysis of the INTERACT Studies
jtitleCerebrovascular diseases (Basel, Switzerland)
addtitleCerebrovasc Dis
date2015-04
risdate2015
volume39
issue3-4
spage242
epage248
pages242-248
issn1015-9770
eissn1421-9786
abstractBackground and Purpose: Early intensive blood pressure (BP) lowering has been shown to improve functional outcome in acute intracerebral hemorrhage (ICH), but the treatment effect is modest and without a clearly defined underlying explanatory mechanism. We aimed at more reliably quantifying the benefits of this treatment according to different time periods in the recovery of participants in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT) studies. Methods: Pooled analysis of the pilot INTERACT1 (n = 404) and main INTERACT2 (n = 2,839) involving patients with spontaneous ICH (<6 h) and elevated systolic BP (SBP 150-220 mm Hg) who were randomized to intensive (target SBP <140 mm Hg) or guideline-recommended (target SBP <180 mm Hg) BP lowering treatment. Treatment effects were examined according to repeated measures analysis of an ordinal (‘shift') across all 7 levels of the modified Rankin Scale (mRS) assessed during follow-up at 7, 28, and 90 days, post-randomization. Clinical trial registration information: http://www.clinicaltrials.gov, NCT00226096 and NCT00716079. Results: Intensive BP lowering resulted in a significant favorable distribution of mRS scores for better functioning (odds ratio 1.13, 95% confidence interval 1.00-1.26; p = 0.042) over 7, 28 and 90 days, and the effect was consistency for early (7-28 days) and later (28-90 days) time periods (p homogeneity 0.353). Treatment effects were also consistent across several pre-specified patient characteristic subgroups, with trends favoring those randomized early, and with higher SBP and milder neurological severity at baseline. Conclusions: Intensive BP lowering provides beneficial effects on physical functioning that manifests consistently through the early and later phases of recovery from ICH.
copBasel, Switzerland
pubS. Karger AG
pmid25823544
doi10.1159/000381107
tpages7