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High expression of ErbB3 binding protein 1 (EBP1) predicts poor prognosis of pancreatic ductal adenocarcinoma (PDAC)

Recent studies have identified that ErbB3 binding protein 1 (EBP1) is broadly expressed in various cancer tissues and critically involved in plenty of biological processes in this regard. However, the functional role of EBP1 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In th... Full description

Journal Title: Tumor biology 2015-12, Vol.36 (12), p.9189-9199
Main Author: Gong, Chen
Other Authors: Zhang, Yixin , Chen, Yinji , Zhang, Haifeng , Liu, Xiaorong , Xue, Huaqing , Ji, Li , Wang, Liang , Yang, Linlin , Zhou, Guoxiong , Wan, Chunhua
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Springer
ID: ISSN: 1010-4283
Link: https://www.ncbi.nlm.nih.gov/pubmed/26088450
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recordid: cdi_pubmed_primary_26088450
title: High expression of ErbB3 binding protein 1 (EBP1) predicts poor prognosis of pancreatic ductal adenocarcinoma (PDAC)
format: Article
creator:
  • Gong, Chen
  • Zhang, Yixin
  • Chen, Yinji
  • Zhang, Haifeng
  • Liu, Xiaorong
  • Xue, Huaqing
  • Ji, Li
  • Wang, Liang
  • Yang, Linlin
  • Zhou, Guoxiong
  • Wan, Chunhua
subjects:
  • Adaptor Proteins, Signal Transducing - biosynthesis
  • Adaptor Proteins, Signal Transducing - genetics
  • Adenocarcinoma
  • Adenocarcinoma - genetics
  • Adenocarcinoma - pathology
  • Adenosine
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis
  • Apoptosis
  • Binding sites
  • Biomarkers, Tumor - biosynthesis
  • Biomarkers, Tumor - genetics
  • Carcinoma, Pancreatic Ductal - genetics
  • Carcinoma, Pancreatic Ductal - pathology
  • Cell Line, Tumor
  • Cell Proliferation
  • Chemical properties
  • Development and progression
  • Female
  • Gene expression
  • Gene Expression Regulation, Neoplastic
  • Health aspects
  • Humans
  • Kaplan-Meier Estimate
  • Lymphatic Metastasis
  • Male
  • Medical diagnosis
  • Middle Aged
  • Neoplasm Staging
  • Pancreatic cancer
  • Prognosis
  • Protein binding
  • Proteins
  • RNA-Binding Proteins - biosynthesis
  • RNA-Binding Proteins - genetics
ispartof: Tumor biology, 2015-12, Vol.36 (12), p.9189-9199
description: Recent studies have identified that ErbB3 binding protein 1 (EBP1) is broadly expressed in various cancer tissues and critically involved in plenty of biological processes in this regard. However, the functional role of EBP1 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that EBP1 could serve as a prognostic biomarker of PDAC. Western blot analysis revealed that EBP1 was remarkably upregulated in PDAC tissues and cell lines. Using immunohistochemical analysis, we showed that the expression of EBP1 was correlated with tumor size (P = 0.004), histological differentiation (P = 0.041), and tumor node metastasis (TNM) stage (P = 0.000). Notably, Kaplan-Meier curve showed that high expression of EBP1 predicted significantly worsened prognosis of PDAC patients (P = 0.001). In addition, knockdown of EBP1 expression suppressed PDAC cell proliferation and retarded cell cycle progression. Furthermore, depletion of EBP1 induced the apoptosis of Panc-1 cells. Of great interest, we found that EBP1 interacted with anti-apoptotic protein, Bcl-xL, and promoted its accumulation. In summary, our results suggest that EBP1 is a novel prognostic indicator and potential therapeutic target of PDAC, shedding new insights into the important role of EBP1 in cancer development.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1010-4283
fulltext: fulltext
issn:
  • 1010-4283
  • 1423-0380
url: Link


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titleHigh expression of ErbB3 binding protein 1 (EBP1) predicts poor prognosis of pancreatic ductal adenocarcinoma (PDAC)
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creatorGong, Chen ; Zhang, Yixin ; Chen, Yinji ; Zhang, Haifeng ; Liu, Xiaorong ; Xue, Huaqing ; Ji, Li ; Wang, Liang ; Yang, Linlin ; Zhou, Guoxiong ; Wan, Chunhua
creatorcontribGong, Chen ; Zhang, Yixin ; Chen, Yinji ; Zhang, Haifeng ; Liu, Xiaorong ; Xue, Huaqing ; Ji, Li ; Wang, Liang ; Yang, Linlin ; Zhou, Guoxiong ; Wan, Chunhua
descriptionRecent studies have identified that ErbB3 binding protein 1 (EBP1) is broadly expressed in various cancer tissues and critically involved in plenty of biological processes in this regard. However, the functional role of EBP1 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that EBP1 could serve as a prognostic biomarker of PDAC. Western blot analysis revealed that EBP1 was remarkably upregulated in PDAC tissues and cell lines. Using immunohistochemical analysis, we showed that the expression of EBP1 was correlated with tumor size (P = 0.004), histological differentiation (P = 0.041), and tumor node metastasis (TNM) stage (P = 0.000). Notably, Kaplan-Meier curve showed that high expression of EBP1 predicted significantly worsened prognosis of PDAC patients (P = 0.001). In addition, knockdown of EBP1 expression suppressed PDAC cell proliferation and retarded cell cycle progression. Furthermore, depletion of EBP1 induced the apoptosis of Panc-1 cells. Of great interest, we found that EBP1 interacted with anti-apoptotic protein, Bcl-xL, and promoted its accumulation. In summary, our results suggest that EBP1 is a novel prognostic indicator and potential therapeutic target of PDAC, shedding new insights into the important role of EBP1 in cancer development.
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subjectAdaptor Proteins, Signal Transducing - biosynthesis ; Adaptor Proteins, Signal Transducing - genetics ; Adenocarcinoma ; Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Adenosine ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Apoptosis ; Binding sites ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - genetics ; Carcinoma, Pancreatic Ductal - genetics ; Carcinoma, Pancreatic Ductal - pathology ; Cell Line, Tumor ; Cell Proliferation ; Chemical properties ; Development and progression ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Health aspects ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Medical diagnosis ; Middle Aged ; Neoplasm Staging ; Pancreatic cancer ; Prognosis ; Protein binding ; Proteins ; RNA-Binding Proteins - biosynthesis ; RNA-Binding Proteins - genetics
ispartofTumor biology, 2015-12, Vol.36 (12), p.9189-9199
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descriptionRecent studies have identified that ErbB3 binding protein 1 (EBP1) is broadly expressed in various cancer tissues and critically involved in plenty of biological processes in this regard. However, the functional role of EBP1 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that EBP1 could serve as a prognostic biomarker of PDAC. Western blot analysis revealed that EBP1 was remarkably upregulated in PDAC tissues and cell lines. Using immunohistochemical analysis, we showed that the expression of EBP1 was correlated with tumor size (P = 0.004), histological differentiation (P = 0.041), and tumor node metastasis (TNM) stage (P = 0.000). Notably, Kaplan-Meier curve showed that high expression of EBP1 predicted significantly worsened prognosis of PDAC patients (P = 0.001). In addition, knockdown of EBP1 expression suppressed PDAC cell proliferation and retarded cell cycle progression. Furthermore, depletion of EBP1 induced the apoptosis of Panc-1 cells. Of great interest, we found that EBP1 interacted with anti-apoptotic protein, Bcl-xL, and promoted its accumulation. In summary, our results suggest that EBP1 is a novel prognostic indicator and potential therapeutic target of PDAC, shedding new insights into the important role of EBP1 in cancer development.
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1Adaptor Proteins, Signal Transducing - genetics
2Adenocarcinoma
3Adenocarcinoma - genetics
4Adenocarcinoma - pathology
5Adenosine
6Adult
7Aged
8Aged, 80 and over
9Analysis
10Apoptosis
11Binding sites
12Biomarkers, Tumor - biosynthesis
13Biomarkers, Tumor - genetics
14Carcinoma, Pancreatic Ductal - genetics
15Carcinoma, Pancreatic Ductal - pathology
16Cell Line, Tumor
17Cell Proliferation
18Chemical properties
19Development and progression
20Female
21Gene expression
22Gene Expression Regulation, Neoplastic
23Health aspects
24Humans
25Kaplan-Meier Estimate
26Lymphatic Metastasis
27Male
28Medical diagnosis
29Middle Aged
30Neoplasm Staging
31Pancreatic cancer
32Prognosis
33Protein binding
34Proteins
35RNA-Binding Proteins - biosynthesis
36RNA-Binding Proteins - genetics
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titleHigh expression of ErbB3 binding protein 1 (EBP1) predicts poor prognosis of pancreatic ductal adenocarcinoma (PDAC)
authorGong, Chen ; Zhang, Yixin ; Chen, Yinji ; Zhang, Haifeng ; Liu, Xiaorong ; Xue, Huaqing ; Ji, Li ; Wang, Liang ; Yang, Linlin ; Zhou, Guoxiong ; Wan, Chunhua
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atitleHigh expression of ErbB3 binding protein 1 (EBP1) predicts poor prognosis of pancreatic ductal adenocarcinoma (PDAC)
jtitleTumor biology
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date2015-12
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volume36
issue12
spage9189
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pages9189-9199
issn1010-4283
eissn1423-0380
abstractRecent studies have identified that ErbB3 binding protein 1 (EBP1) is broadly expressed in various cancer tissues and critically involved in plenty of biological processes in this regard. However, the functional role of EBP1 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that EBP1 could serve as a prognostic biomarker of PDAC. Western blot analysis revealed that EBP1 was remarkably upregulated in PDAC tissues and cell lines. Using immunohistochemical analysis, we showed that the expression of EBP1 was correlated with tumor size (P = 0.004), histological differentiation (P = 0.041), and tumor node metastasis (TNM) stage (P = 0.000). Notably, Kaplan-Meier curve showed that high expression of EBP1 predicted significantly worsened prognosis of PDAC patients (P = 0.001). In addition, knockdown of EBP1 expression suppressed PDAC cell proliferation and retarded cell cycle progression. Furthermore, depletion of EBP1 induced the apoptosis of Panc-1 cells. Of great interest, we found that EBP1 interacted with anti-apoptotic protein, Bcl-xL, and promoted its accumulation. In summary, our results suggest that EBP1 is a novel prognostic indicator and potential therapeutic target of PDAC, shedding new insights into the important role of EBP1 in cancer development.
copUnited States
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pmid26088450
doi10.1007/s13277-015-3625-6
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