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Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium

In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidenc... Full description

Journal Title: Current medical research and opinion 2017-02-01, Vol.33 (2), p.239-251
Main Author: Sposito, Andrei C.
Other Authors: Faria Neto, José Rocha , Carvalho, Luiz Sergio F. de , Lorenzatti, Alberto , Cafferata, Alberto , Elikir, Gerardo , Esteban, Eduardo , Morales Villegas, Enrique C. , Bodanese, Luiz Carlos , Alonso, Rodrigo , Ruiz, Alvaro J. , Rocha, Viviane Z. , Faludi, André A. , Xavier, Hermes T. , Coelho, Otávio Rizzi , Assad, Marcelo H.V. , Izar, Maria C. , Santos, Raul D. , Fonseca, Francisco A.H. , Mello e Silva, Alberto , Silva, Pedro Marques da , Bertolami, Marcelo C.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Taylor & Francis
ID: ISSN: 0300-7995
Link: https://www.ncbi.nlm.nih.gov/pubmed/27776432
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recordid: cdi_pubmed_primary_27776432
title: Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium
format: Article
creator:
  • Sposito, Andrei C.
  • Faria Neto, José Rocha
  • Carvalho, Luiz Sergio F. de
  • Lorenzatti, Alberto
  • Cafferata, Alberto
  • Elikir, Gerardo
  • Esteban, Eduardo
  • Morales Villegas, Enrique C.
  • Bodanese, Luiz Carlos
  • Alonso, Rodrigo
  • Ruiz, Alvaro J.
  • Rocha, Viviane Z.
  • Faludi, André A.
  • Xavier, Hermes T.
  • Coelho, Otávio Rizzi
  • Assad, Marcelo H.V.
  • Izar, Maria C.
  • Santos, Raul D.
  • Fonseca, Francisco A.H.
  • Mello e Silva, Alberto
  • Silva, Pedro Marques da
  • Bertolami, Marcelo C.
subjects:
  • Cardiovascular Diseases - prevention & control
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
  • Intolerance
  • Muscular Diseases - chemically induced
  • Risk Factors
  • statin
  • statin associated muscle symptoms
ispartof: Current medical research and opinion, 2017-02-01, Vol.33 (2), p.239-251
description: In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, the Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0300-7995
fulltext: fulltext
issn:
  • 0300-7995
  • 1473-4877
url: Link


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titleStatin-associated muscle symptoms: position paper from the Luso-Latin American Consortium
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creatorSposito, Andrei C. ; Faria Neto, José Rocha ; Carvalho, Luiz Sergio F. de ; Lorenzatti, Alberto ; Cafferata, Alberto ; Elikir, Gerardo ; Esteban, Eduardo ; Morales Villegas, Enrique C. ; Bodanese, Luiz Carlos ; Alonso, Rodrigo ; Ruiz, Alvaro J. ; Rocha, Viviane Z. ; Faludi, André A. ; Xavier, Hermes T. ; Coelho, Otávio Rizzi ; Assad, Marcelo H.V. ; Izar, Maria C. ; Santos, Raul D. ; Fonseca, Francisco A.H. ; Mello e Silva, Alberto ; Silva, Pedro Marques da ; Bertolami, Marcelo C.
creatorcontribSposito, Andrei C. ; Faria Neto, José Rocha ; Carvalho, Luiz Sergio F. de ; Lorenzatti, Alberto ; Cafferata, Alberto ; Elikir, Gerardo ; Esteban, Eduardo ; Morales Villegas, Enrique C. ; Bodanese, Luiz Carlos ; Alonso, Rodrigo ; Ruiz, Alvaro J. ; Rocha, Viviane Z. ; Faludi, André A. ; Xavier, Hermes T. ; Coelho, Otávio Rizzi ; Assad, Marcelo H.V. ; Izar, Maria C. ; Santos, Raul D. ; Fonseca, Francisco A.H. ; Mello e Silva, Alberto ; Silva, Pedro Marques da ; Bertolami, Marcelo C. ; on behalf of the Luso-Latin American Consortium on Statin-Associated Muscle Symptoms
descriptionIn the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, the Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS.
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subjectCardiovascular Diseases - prevention & control ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Intolerance ; Muscular Diseases - chemically induced ; Risk Factors ; statin ; statin associated muscle symptoms
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titleStatin-associated muscle symptoms: position paper from the Luso-Latin American Consortium
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abstractIn the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, the Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS.
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doi10.1080/03007995.2016.1252740
orcididhttps://orcid.org/0000-0002-1397-0634