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Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched... Full description

Journal Title: Annual review of immunology 2018-04-26, Vol.36 (1), p.435-459
Main Author: Lindenbergh, Marthe F.S
Other Authors: Stoorvogel, Willem
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Annual Reviews
ID: ISSN: 0732-0582
Link: https://www.ncbi.nlm.nih.gov/pubmed/29400984
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recordid: cdi_pubmed_primary_29400984
title: Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells
format: Article
creator:
  • Lindenbergh, Marthe F.S
  • Stoorvogel, Willem
subjects:
  • Antigens
  • B cells
  • Dendritic cells
  • exosomes
  • MHC molecules
  • microvesicles
  • Physiological aspects
  • T cells
ispartof: Annual review of immunology, 2018-04-26, Vol.36 (1), p.435-459
description: The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched off from the plasma membrane or as exosomes secreted by multivesicular endosomes. Membrane receptors guide EVs to specific target cells, allowing directional transfer of specific and complex signaling cues. EVs are released by most, if not all, immune cells. Depending on the type and status of their originating cell, EVs may facilitate the initiation, expansion, maintenance, or silencing of adaptive immune responses. This review focusses on EVs from professional antigen-presenting cells, their demonstrated and speculated roles, and their potential for cancer immunotherapy.
language: eng
source:
identifier: ISSN: 0732-0582
fulltext: no_fulltext
issn:
  • 0732-0582
  • 1545-3278
url: Link


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descriptionThe initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched off from the plasma membrane or as exosomes secreted by multivesicular endosomes. Membrane receptors guide EVs to specific target cells, allowing directional transfer of specific and complex signaling cues. EVs are released by most, if not all, immune cells. Depending on the type and status of their originating cell, EVs may facilitate the initiation, expansion, maintenance, or silencing of adaptive immune responses. This review focusses on EVs from professional antigen-presenting cells, their demonstrated and speculated roles, and their potential for cancer immunotherapy.
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subjectAntigens ; B cells ; Dendritic cells ; exosomes ; MHC molecules ; microvesicles ; Physiological aspects ; T cells
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abstractThe initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs). EVs can be formed as microvesicles directly pinched off from the plasma membrane or as exosomes secreted by multivesicular endosomes. Membrane receptors guide EVs to specific target cells, allowing directional transfer of specific and complex signaling cues. EVs are released by most, if not all, immune cells. Depending on the type and status of their originating cell, EVs may facilitate the initiation, expansion, maintenance, or silencing of adaptive immune responses. This review focusses on EVs from professional antigen-presenting cells, their demonstrated and speculated roles, and their potential for cancer immunotherapy.
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