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Transurethral Prostatectomy in Patients with Preoperative Bacteriuria: Double-Blind Study with Oral Fleroxacin and Cefalexin

We compared oral fleroxacin and cefalexin in the prevention of postoperative infectious complications after transurethral prostatectomy (TURP) in patients with preoperative bacteriuria. 95 patients underwent TURP due to benign prostatic hyperplasia with preoperative bacteriuria . The therapy consist... Full description

Journal Title: Chemotherapy (Basel) 1998-02, Vol.44 (1), p.69-75
Main Author: Viitanen, Jouko
Other Authors: Malminiemi, Kimmo , Kallio, Jukka , Puolakka, Veli-Matti , Rajala, Pertti , Tammela, Teuvo L.J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: Karger
ID: ISSN: 0009-3157
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recordid: cdi_pubmed_primary_9444412
title: Transurethral Prostatectomy in Patients with Preoperative Bacteriuria: Double-Blind Study with Oral Fleroxacin and Cefalexin
format: Article
creator:
  • Viitanen, Jouko
  • Malminiemi, Kimmo
  • Kallio, Jukka
  • Puolakka, Veli-Matti
  • Rajala, Pertti
  • Tammela, Teuvo L.J
subjects:
  • Administration, Oral
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents - therapeutic use
  • Antibacterial agents
  • Antibiotics. Antiinfectious agents. Antiparasitic agents
  • Bacteriuria - drug therapy
  • Biological and medical sciences
  • Cephalexin - therapeutic use
  • Cephalosporins - therapeutic use
  • Clinical Report
  • Double-Blind Method
  • Fleroxacin - therapeutic use
  • Humans
  • Male
  • Medical sciences
  • Middle Aged
  • Pharmacology. Drug treatments
  • Postoperative Complications - prevention & control
  • Preoperative Care
  • Prospective Studies
  • Prostatectomy
  • Prostatic Hyperplasia - surgery
ispartof: Chemotherapy (Basel), 1998-02, Vol.44 (1), p.69-75
description: We compared oral fleroxacin and cefalexin in the prevention of postoperative infectious complications after transurethral prostatectomy (TURP) in patients with preoperative bacteriuria. 95 patients underwent TURP due to benign prostatic hyperplasia with preoperative bacteriuria . The therapy consisted of 7 days of oral fleroxacin 400 mg once a day or cefalexin 500 mg three times daily. After 2 weeks, 62% of the urine samples were sterile in the fleroxacin group but only 37% in the cefalexin group (p = 0.047). Patients in the cefalexin group had also statistically significantly more symptoms of urinary tract infections. After 6 weeks, the bacterial eradication rate was 53% in the fleroxacin group and 37% in the cefalexin group. There were no septicemias. TURP can be performed with reasonable safety with this oral anbiotic therapy.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0009-3157
fulltext: fulltext
issn:
  • 0009-3157
  • 1421-9794
url: Link


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descriptionWe compared oral fleroxacin and cefalexin in the prevention of postoperative infectious complications after transurethral prostatectomy (TURP) in patients with preoperative bacteriuria. 95 patients underwent TURP due to benign prostatic hyperplasia with preoperative bacteriuria . The therapy consisted of 7 days of oral fleroxacin 400 mg once a day or cefalexin 500 mg three times daily. After 2 weeks, 62% of the urine samples were sterile in the fleroxacin group but only 37% in the cefalexin group (p = 0.047). Patients in the cefalexin group had also statistically significantly more symptoms of urinary tract infections. After 6 weeks, the bacterial eradication rate was 53% in the fleroxacin group and 37% in the cefalexin group. There were no septicemias. TURP can be performed with reasonable safety with this oral anbiotic therapy.
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subjectAdministration, Oral ; Aged ; Aged, 80 and over ; Anti-Infective Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteriuria - drug therapy ; Biological and medical sciences ; Cephalexin - therapeutic use ; Cephalosporins - therapeutic use ; Clinical Report ; Double-Blind Method ; Fleroxacin - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Preoperative Care ; Prospective Studies ; Prostatectomy ; Prostatic Hyperplasia - surgery
ispartofChemotherapy (Basel), 1998-02, Vol.44 (1), p.69-75
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abstractWe compared oral fleroxacin and cefalexin in the prevention of postoperative infectious complications after transurethral prostatectomy (TURP) in patients with preoperative bacteriuria. 95 patients underwent TURP due to benign prostatic hyperplasia with preoperative bacteriuria . The therapy consisted of 7 days of oral fleroxacin 400 mg once a day or cefalexin 500 mg three times daily. After 2 weeks, 62% of the urine samples were sterile in the fleroxacin group but only 37% in the cefalexin group (p = 0.047). Patients in the cefalexin group had also statistically significantly more symptoms of urinary tract infections. After 6 weeks, the bacterial eradication rate was 53% in the fleroxacin group and 37% in the cefalexin group. There were no septicemias. TURP can be performed with reasonable safety with this oral anbiotic therapy.
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