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Genetic aspects of antibiotic induced deafness: mitochondrial inheritance

Analysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inhe... Full description

Journal Title: Journal of medical genetics 1991, Vol.28 (2), p.79-83
Main Author: Hu, D N
Other Authors: Qui, W Q , Wu, B T , Fang, L Z , Zhou, F , Gu, Y P , Zhang, Q H , Yan, J H , Ding, Y Q , Wong, H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Aminoglycosides
Anti-Bacterial Agents - adverse effects
Biological and medical sciences
Chi-Square Distribution
China
Deafness - chemically induced
DNA, Mitochondrial
Drug Hypersensitivity - genetics
Drug toxicity and drugs side effects treatment
Female
Hearing Loss - chemically induced
Humans
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Mothers
Pedigree
Pharmacology. Drug treatments
Research Article
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd
ID: ISSN: 0022-2593
Zum Text:
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1016772
title: Genetic aspects of antibiotic induced deafness: mitochondrial inheritance
format: Article
creator:
  • Hu, D N
  • Qui, W Q
  • Wu, B T
  • Fang, L Z
  • Zhou, F
  • Gu, Y P
  • Zhang, Q H
  • Yan, J H
  • Ding, Y Q
  • Wong, H
subjects:
  • Aminoglycosides
  • Anti-Bacterial Agents - adverse effects
  • Biological and medical sciences
  • Chi-Square Distribution
  • China
  • Deafness - chemically induced
  • DNA, Mitochondrial
  • Drug Hypersensitivity - genetics
  • Drug toxicity and drugs side effects treatment
  • Female
  • Hearing Loss - chemically induced
  • Humans
  • Male
  • Medical sciences
  • Miscellaneous (drug allergy, mutagens, teratogens...)
  • Mothers
  • Pedigree
  • Pharmacology. Drug treatments
  • Research Article
ispartof: Journal of medical genetics, 1991, Vol.28 (2), p.79-83
description: Analysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0022-2593
fulltext: fulltext
issn:
  • 0022-2593
  • 1468-6244
  • 1468-6244
url: Link


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descriptionAnalysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.
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subjectAminoglycosides ; Anti-Bacterial Agents - adverse effects ; Biological and medical sciences ; Chi-Square Distribution ; China ; Deafness - chemically induced ; DNA, Mitochondrial ; Drug Hypersensitivity - genetics ; Drug toxicity and drugs side effects treatment ; Female ; Hearing Loss - chemically induced ; Humans ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Mothers ; Pedigree ; Pharmacology. Drug treatments ; Research Article
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descriptionAnalysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.
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1Anti-Bacterial Agents - adverse effects
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6DNA, Mitochondrial
7Drug Hypersensitivity - genetics
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13Medical sciences
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abstractAnalysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483,611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.
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