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Plasma beta endorphin in cirrhosis and renal failure

Whether the plasma concentration of beta endorphin was increased in hepatic cirrhosis like that of smaller opioid peptides methionine enkephalin and leucine enkephalin was determined. Its concentration in chronic renal failure was also measured. Plasma beta endorphin was not significantly raised in... Full description

Journal Title: Gut 1991-03, Vol.32 (3), p.306-308
Main Author: Thornton, J R
Other Authors: Losowsky, M S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and British Society of Gastroenterology
ID: ISSN: 0017-5749
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1378840
title: Plasma beta endorphin in cirrhosis and renal failure
format: Article
creator:
  • Thornton, J R
  • Losowsky, M S
subjects:
  • Abridged Index Medicus
  • Beta-endorphin
  • beta-Endorphin - blood
  • beta-Endorphin - urine
  • Biological and medical sciences
  • Chronic kidney failure
  • Gastroenterology. Liver. Pancreas. Abdomen
  • Humans
  • Kidney Failure, Chronic - blood
  • Kidney Failure, Chronic - urine
  • Liver cirrhosis
  • Liver Cirrhosis - blood
  • Liver. Biliary tract. Portal circulation. Exocrine pancreas
  • Measurement
  • Medical sciences
  • Other diseases. Semiology
  • Peptides
  • Physiological aspects
  • Research Article
ispartof: Gut, 1991-03, Vol.32 (3), p.306-308
description: Whether the plasma concentration of beta endorphin was increased in hepatic cirrhosis like that of smaller opioid peptides methionine enkephalin and leucine enkephalin was determined. Its concentration in chronic renal failure was also measured. Plasma beta endorphin was not significantly raised in cirrhotic patients with or without ascites (medians 5.2 pmol/l and 4.7 pmol/l respectively) compared with disease control subjects (4.9 pmol/l) and healthy control subjects (4.9 pmol/l). In contrast, the peptide was increased 2.5 fold (p less than 0.001) in chronic renal failure (12.4 pmol/l) and was found in many of these patients' urine. The data are compatible with the hypothesis that the liver may play an important role in the elimination of opioid peptides of octapeptide size or less but not the larger peptides such as beta endorphin.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0017-5749
fulltext: fulltext
issn:
  • 0017-5749
  • 1468-3288
url: Link


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descriptionWhether the plasma concentration of beta endorphin was increased in hepatic cirrhosis like that of smaller opioid peptides methionine enkephalin and leucine enkephalin was determined. Its concentration in chronic renal failure was also measured. Plasma beta endorphin was not significantly raised in cirrhotic patients with or without ascites (medians 5.2 pmol/l and 4.7 pmol/l respectively) compared with disease control subjects (4.9 pmol/l) and healthy control subjects (4.9 pmol/l). In contrast, the peptide was increased 2.5 fold (p less than 0.001) in chronic renal failure (12.4 pmol/l) and was found in many of these patients' urine. The data are compatible with the hypothesis that the liver may play an important role in the elimination of opioid peptides of octapeptide size or less but not the larger peptides such as beta endorphin.
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subjectAbridged Index Medicus ; Beta-endorphin ; beta-Endorphin - blood ; beta-Endorphin - urine ; Biological and medical sciences ; Chronic kidney failure ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - urine ; Liver cirrhosis ; Liver Cirrhosis - blood ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Measurement ; Medical sciences ; Other diseases. Semiology ; Peptides ; Physiological aspects ; Research Article
ispartofGut, 1991-03, Vol.32 (3), p.306-308
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descriptionWhether the plasma concentration of beta endorphin was increased in hepatic cirrhosis like that of smaller opioid peptides methionine enkephalin and leucine enkephalin was determined. Its concentration in chronic renal failure was also measured. Plasma beta endorphin was not significantly raised in cirrhotic patients with or without ascites (medians 5.2 pmol/l and 4.7 pmol/l respectively) compared with disease control subjects (4.9 pmol/l) and healthy control subjects (4.9 pmol/l). In contrast, the peptide was increased 2.5 fold (p less than 0.001) in chronic renal failure (12.4 pmol/l) and was found in many of these patients' urine. The data are compatible with the hypothesis that the liver may play an important role in the elimination of opioid peptides of octapeptide size or less but not the larger peptides such as beta endorphin.
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abstractWhether the plasma concentration of beta endorphin was increased in hepatic cirrhosis like that of smaller opioid peptides methionine enkephalin and leucine enkephalin was determined. Its concentration in chronic renal failure was also measured. Plasma beta endorphin was not significantly raised in cirrhotic patients with or without ascites (medians 5.2 pmol/l and 4.7 pmol/l respectively) compared with disease control subjects (4.9 pmol/l) and healthy control subjects (4.9 pmol/l). In contrast, the peptide was increased 2.5 fold (p less than 0.001) in chronic renal failure (12.4 pmol/l) and was found in many of these patients' urine. The data are compatible with the hypothesis that the liver may play an important role in the elimination of opioid peptides of octapeptide size or less but not the larger peptides such as beta endorphin.
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