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Biliary lipids, faecal steroids, and liver function in patients with chronic active hepatitis and primary biliary cirrhosis: significance of hepatic orcein-stained complexes

Biliary lipids, faecal steroids, and serum bile acids were studied in patients with chronic active hepatitis and primary biliary cirrhosis. The results were correlated with excretory and parenchymal liver function tests and with the presence or absence of orcein-positive copper-protein complexes in... Full description

Journal Title: Gut 1981-07, Vol.22 (7), p.579-584
Main Author: Kesäniemi, Y A
Other Authors: Miettinen, T A , Salaspuro, M P
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group Ltd and British Society of Gastroenterology
ID: ISSN: 0017-5749
Link: https://www.ncbi.nlm.nih.gov/pubmed/6167493
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1419325
title: Biliary lipids, faecal steroids, and liver function in patients with chronic active hepatitis and primary biliary cirrhosis: significance of hepatic orcein-stained complexes
format: Article
creator:
  • Kesäniemi, Y A
  • Miettinen, T A
  • Salaspuro, M P
subjects:
  • Abridged Index Medicus
  • Adult
  • Bile - analysis
  • Bile Acids and Salts - analysis
  • Carrier Proteins - analysis
  • Cholesterol - analysis
  • Chronic Disease
  • Copper - analysis
  • Feces - analysis
  • Female
  • Hepatitis - metabolism
  • Humans
  • Liver - analysis
  • Liver Cirrhosis, Biliary - metabolism
  • Liver Function Tests
  • Male
  • Middle Aged
  • Oxazines
  • Phospholipids - analysis
  • Research Article
  • Staining and Labeling
  • Sterols - analysis
ispartof: Gut, 1981-07, Vol.22 (7), p.579-584
description: Biliary lipids, faecal steroids, and serum bile acids were studied in patients with chronic active hepatitis and primary biliary cirrhosis. The results were correlated with excretory and parenchymal liver function tests and with the presence or absence of orcein-positive copper-protein complexes in histological liver specimens. In general, faecal bile acids, but not neutral and total sterols, correlated negatively with the percentage of biliary cholic acid, serum cholesterol, and serum bile acids and positively with the percentage of biliary deoxycholic acid. In orcein-positive subjects-indicative of long-standing cholestasis-the bile was undersaturated with cholesterol, biliary deoxycholic acid was subnormal, cholic acid correspondingly increased, and serum cholesterol and bile acids were raised. Only patients with marked impairment of both excretory and parenchymal liver functions had a decreased output of neutral sterols, bile acids, and total steroids, and, thus, low bile acid and cholesterol synthesis. The findings indicate that mild disturbances in parenchymal liver function infrequently cause major changes in cholesterol metabolism, while abnormalities in secretory liver function-in orcein-positive subjects especially-are frequently associated with proportionate changes in parameters of cholesterol metabolism.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0017-5749
fulltext: fulltext
issn:
  • 0017-5749
  • 1468-3288
url: Link


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descriptionBiliary lipids, faecal steroids, and serum bile acids were studied in patients with chronic active hepatitis and primary biliary cirrhosis. The results were correlated with excretory and parenchymal liver function tests and with the presence or absence of orcein-positive copper-protein complexes in histological liver specimens. In general, faecal bile acids, but not neutral and total sterols, correlated negatively with the percentage of biliary cholic acid, serum cholesterol, and serum bile acids and positively with the percentage of biliary deoxycholic acid. In orcein-positive subjects-indicative of long-standing cholestasis-the bile was undersaturated with cholesterol, biliary deoxycholic acid was subnormal, cholic acid correspondingly increased, and serum cholesterol and bile acids were raised. Only patients with marked impairment of both excretory and parenchymal liver functions had a decreased output of neutral sterols, bile acids, and total steroids, and, thus, low bile acid and cholesterol synthesis. The findings indicate that mild disturbances in parenchymal liver function infrequently cause major changes in cholesterol metabolism, while abnormalities in secretory liver function-in orcein-positive subjects especially-are frequently associated with proportionate changes in parameters of cholesterol metabolism.
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subjectAbridged Index Medicus ; Adult ; Bile - analysis ; Bile Acids and Salts - analysis ; Carrier Proteins - analysis ; Cholesterol - analysis ; Chronic Disease ; Copper - analysis ; Feces - analysis ; Female ; Hepatitis - metabolism ; Humans ; Liver - analysis ; Liver Cirrhosis, Biliary - metabolism ; Liver Function Tests ; Male ; Middle Aged ; Oxazines ; Phospholipids - analysis ; Research Article ; Staining and Labeling ; Sterols - analysis
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abstractBiliary lipids, faecal steroids, and serum bile acids were studied in patients with chronic active hepatitis and primary biliary cirrhosis. The results were correlated with excretory and parenchymal liver function tests and with the presence or absence of orcein-positive copper-protein complexes in histological liver specimens. In general, faecal bile acids, but not neutral and total sterols, correlated negatively with the percentage of biliary cholic acid, serum cholesterol, and serum bile acids and positively with the percentage of biliary deoxycholic acid. In orcein-positive subjects-indicative of long-standing cholestasis-the bile was undersaturated with cholesterol, biliary deoxycholic acid was subnormal, cholic acid correspondingly increased, and serum cholesterol and bile acids were raised. Only patients with marked impairment of both excretory and parenchymal liver functions had a decreased output of neutral sterols, bile acids, and total steroids, and, thus, low bile acid and cholesterol synthesis. The findings indicate that mild disturbances in parenchymal liver function infrequently cause major changes in cholesterol metabolism, while abnormalities in secretory liver function-in orcein-positive subjects especially-are frequently associated with proportionate changes in parameters of cholesterol metabolism.
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