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Different types of smooth muscle antibodies in chronic active hepatitis and primary biliary cirrhosis: their diagnostic and prognostic significance

The diagnostic and prognostic significance of the different types of serum smooth muscle antibodies (SMA) were investigated in sera of 24 patients with chronic active hepatitis (CAH) and 15 patients with primary biliary cirrhosis (PBC). SMA of IgG class were found in 92% of sera from patients with C... Full description

Journal Title: Gut 1980, Vol.21 (10), p.878-884
Main Author: Kurki, P
Other Authors: Miettinen, A , Linder, E , Pikkarainen, P , Vuoristo, M , Salaspuro, M P
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group Ltd and British Society of Gastroenterology
ID: ISSN: 0017-5749
Link: https://www.ncbi.nlm.nih.gov/pubmed/7002738
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1419380
title: Different types of smooth muscle antibodies in chronic active hepatitis and primary biliary cirrhosis: their diagnostic and prognostic significance
format: Article
creator:
  • Kurki, P
  • Miettinen, A
  • Linder, E
  • Pikkarainen, P
  • Vuoristo, M
  • Salaspuro, M P
subjects:
  • Abridged Index Medicus
  • Adult
  • Aged
  • Antibody Specificity
  • Bile Canaliculi - immunology
  • Chronic Disease
  • connective tissue diseases
  • Female
  • female genital diseases
  • Fluorescent Antibody Technique
  • Hepatitis - diagnosis
  • Hepatitis - immunology
  • Humans
  • Immunoglobulins - analysis
  • Kidney Glomerulus - immunology
  • Liver Cirrhosis, Biliary - diagnosis
  • Liver Cirrhosis, Biliary - immunology
  • Male
  • male genital diseases
  • Middle Aged
  • Muscle, Smooth - immunology
  • pregnancy complications
  • Prognosis
  • Research Article
  • skin
  • urologic
ispartof: Gut, 1980, Vol.21 (10), p.878-884
description: The diagnostic and prognostic significance of the different types of serum smooth muscle antibodies (SMA) were investigated in sera of 24 patients with chronic active hepatitis (CAH) and 15 patients with primary biliary cirrhosis (PBC). SMA of IgG class were found in 92% of sera from patients with CAH but in only 20% of sera from PBC patients, whereas the incidence of IgM-SMA was higher in PBC (67%) than in CAH (38%). All six patients with the atypical cholestatic form of CAH has SMA of IgM class, whereas other CAH patients had SMA of mainly IgG class. SMA reacting with rabbit liver (bile canaliculus antibodies, BCA) and with rat glomeruli (glomerulus antibodies) were of anti-actin specificity and were more common in CAH than in PBC. Organ specific BCA or glomerulus antibodies were not found. Anti-actin antibodies were detected in the majority of the investigated sera by an immunoenzymatic anti-actin assay. The results suggest that the determination of SMA titres with heavy chain specific antisera may help in the assessment of diagnosis and prognosis of chronic hepatitis.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0017-5749
fulltext: fulltext
issn:
  • 0017-5749
  • 1468-3288
url: Link


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descriptionThe diagnostic and prognostic significance of the different types of serum smooth muscle antibodies (SMA) were investigated in sera of 24 patients with chronic active hepatitis (CAH) and 15 patients with primary biliary cirrhosis (PBC). SMA of IgG class were found in 92% of sera from patients with CAH but in only 20% of sera from PBC patients, whereas the incidence of IgM-SMA was higher in PBC (67%) than in CAH (38%). All six patients with the atypical cholestatic form of CAH has SMA of IgM class, whereas other CAH patients had SMA of mainly IgG class. SMA reacting with rabbit liver (bile canaliculus antibodies, BCA) and with rat glomeruli (glomerulus antibodies) were of anti-actin specificity and were more common in CAH than in PBC. Organ specific BCA or glomerulus antibodies were not found. Anti-actin antibodies were detected in the majority of the investigated sera by an immunoenzymatic anti-actin assay. The results suggest that the determination of SMA titres with heavy chain specific antisera may help in the assessment of diagnosis and prognosis of chronic hepatitis.
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subjectAbridged Index Medicus ; Adult ; Aged ; Antibody Specificity ; Bile Canaliculi - immunology ; Chronic Disease ; connective tissue diseases ; Female ; female genital diseases ; Fluorescent Antibody Technique ; Hepatitis - diagnosis ; Hepatitis - immunology ; Humans ; Immunoglobulins - analysis ; Kidney Glomerulus - immunology ; Liver Cirrhosis, Biliary - diagnosis ; Liver Cirrhosis, Biliary - immunology ; Male ; male genital diseases ; Middle Aged ; Muscle, Smooth - immunology ; pregnancy complications ; Prognosis ; Research Article ; skin ; urologic
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descriptionThe diagnostic and prognostic significance of the different types of serum smooth muscle antibodies (SMA) were investigated in sera of 24 patients with chronic active hepatitis (CAH) and 15 patients with primary biliary cirrhosis (PBC). SMA of IgG class were found in 92% of sera from patients with CAH but in only 20% of sera from PBC patients, whereas the incidence of IgM-SMA was higher in PBC (67%) than in CAH (38%). All six patients with the atypical cholestatic form of CAH has SMA of IgM class, whereas other CAH patients had SMA of mainly IgG class. SMA reacting with rabbit liver (bile canaliculus antibodies, BCA) and with rat glomeruli (glomerulus antibodies) were of anti-actin specificity and were more common in CAH than in PBC. Organ specific BCA or glomerulus antibodies were not found. Anti-actin antibodies were detected in the majority of the investigated sera by an immunoenzymatic anti-actin assay. The results suggest that the determination of SMA titres with heavy chain specific antisera may help in the assessment of diagnosis and prognosis of chronic hepatitis.
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abstractThe diagnostic and prognostic significance of the different types of serum smooth muscle antibodies (SMA) were investigated in sera of 24 patients with chronic active hepatitis (CAH) and 15 patients with primary biliary cirrhosis (PBC). SMA of IgG class were found in 92% of sera from patients with CAH but in only 20% of sera from PBC patients, whereas the incidence of IgM-SMA was higher in PBC (67%) than in CAH (38%). All six patients with the atypical cholestatic form of CAH has SMA of IgM class, whereas other CAH patients had SMA of mainly IgG class. SMA reacting with rabbit liver (bile canaliculus antibodies, BCA) and with rat glomeruli (glomerulus antibodies) were of anti-actin specificity and were more common in CAH than in PBC. Organ specific BCA or glomerulus antibodies were not found. Anti-actin antibodies were detected in the majority of the investigated sera by an immunoenzymatic anti-actin assay. The results suggest that the determination of SMA titres with heavy chain specific antisera may help in the assessment of diagnosis and prognosis of chronic hepatitis.
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