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Plasma malondialdehyde and nitric oxide levels in age related macular degeneration

AIMS To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were... Full description

Journal Title: British journal of ophthalmology 2001, Vol.85 (12), p.1426-1428
Main Author: Totan, Yüksel
Other Authors: Çekiç, Osman , Borazan, Mehmet , Uz, Efkan , Sög̈üt, Sadık , Akyol, Ömer
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd
ID: ISSN: 0007-1161
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1723807
title: Plasma malondialdehyde and nitric oxide levels in age related macular degeneration
format: Article
creator:
  • Totan, Yüksel
  • Çekiç, Osman
  • Borazan, Mehmet
  • Uz, Efkan
  • Sög̈üt, Sadık
  • Akyol, Ömer
subjects:
  • Age
  • age related macular degeneration
  • Aged
  • Aging
  • Antioxidants
  • Biological and medical sciences
  • Biomarkers - blood
  • Eye diseases
  • Family medical history
  • Female
  • Free radicals
  • Humans
  • Lipid Peroxidation
  • Lipids
  • Macular degeneration
  • Macular Degeneration - blood
  • Macular Degeneration - physiopathology
  • Male
  • malondialdehyde
  • Malondialdehyde - blood
  • Medical sciences
  • Middle Aged
  • Nitrates - blood
  • Nitric oxide
  • Nitric Oxide - blood
  • Nitrites - blood
  • Ophthalmology
  • Oxidative stress
  • Pathogenesis
  • Plasma
  • Retina
  • Retinal degeneration
  • Retinopathies
  • Rodents
  • Scientific Correspondence
  • Studies
ispartof: British journal of ophthalmology, 2001, Vol.85 (12), p.1426-1428
description: AIMS To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. RESULTS Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). CONCLUSION The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0007-1161
fulltext: fulltext
issn:
  • 0007-1161
  • 1468-2079
url: Link


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descriptionAIMS To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. RESULTS Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). CONCLUSION The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.
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subjectAge ; age related macular degeneration ; Aged ; Aging ; Antioxidants ; Biological and medical sciences ; Biomarkers - blood ; Eye diseases ; Family medical history ; Female ; Free radicals ; Humans ; Lipid Peroxidation ; Lipids ; Macular degeneration ; Macular Degeneration - blood ; Macular Degeneration - physiopathology ; Male ; malondialdehyde ; Malondialdehyde - blood ; Medical sciences ; Middle Aged ; Nitrates - blood ; Nitric oxide ; Nitric Oxide - blood ; Nitrites - blood ; Ophthalmology ; Oxidative stress ; Pathogenesis ; Plasma ; Retina ; Retinal degeneration ; Retinopathies ; Rodents ; Scientific Correspondence ; Studies
ispartofBritish journal of ophthalmology, 2001, Vol.85 (12), p.1426-1428
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descriptionAIMS To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. RESULTS Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). CONCLUSION The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.
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abstractAIMS To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. RESULTS Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). CONCLUSION The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.
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