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Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis

BACKGROUND AND AIMS It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocyt... Full description

Journal Title: Gut 1999-09, Vol.45 (3), p.375-381
Main Author: Baert, F
Other Authors: Wouters, K , D’Haens, G , Hoang, P , Naegels, S , D’Heygere, F , Holvoet, J , Louis, E , Devos, M , Geboes, K
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and British Society of Gastroenterology
ID: ISSN: 0017-5749
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1727642
title: Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis
format: Article
creator:
  • Baert, F
  • Wouters, K
  • D’Haens, G
  • Hoang, P
  • Naegels, S
  • D’Heygere, F
  • Holvoet, J
  • Louis, E
  • Devos, M
  • Geboes, K
subjects:
  • Abridged Index Medicus
  • Adult
  • adverse effects
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • analysis
  • Article
  • Biological and medical sciences
  • Celiac disease
  • Colitis
  • Colitis - etiology
  • Colitis - metabolism
  • Colitis - pathology
  • Colitis/etiology/metabolism/pathology
  • Collagen
  • Collagen - analysis
  • collagenous colitis
  • Diarrhea
  • diarrhoea
  • Drugs
  • etiology
  • Female
  • Follow
  • Follow-Up Studies
  • Gastroenterology & hepatology
  • Gastroenterology. Liver. Pancreas. Abdomen
  • Gastroentérologie & hépatologie
  • Gluten
  • Hospitals
  • Human health sciences
  • Humans
  • Inflammatory bowel disease
  • Laboratories
  • lymphocytic colitis
  • Lymphocytosis
  • Lymphocytosis - etiology
  • Lymphocytosis - pathology
  • Lymphocytosis/etiology/pathology
  • Male
  • Medical sciences
  • metabolism
  • Middle Aged
  • Other diseases. Semiology
  • over
  • pathology
  • Prognosis
  • Risk Factors
  • Sciences de la santé humaine
  • Sex Distribution
  • Smoking
  • Smoking - adverse effects
  • Statistical analysis
  • Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
  • Studies
  • Up Studies
ispartof: Gut, 1999-09, Vol.45 (3), p.375-381
description: BACKGROUND AND AIMS It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0017-5749
fulltext: fulltext
issn:
  • 0017-5749
  • 1468-3288
  • 1468-3288
url: Link


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descriptionBACKGROUND AND AIMS It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis.
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subjectAbridged Index Medicus ; Adult ; adverse effects ; Age Distribution ; Aged ; Aged, 80 and over ; analysis ; Article ; Biological and medical sciences ; Celiac disease ; Colitis ; Colitis - etiology ; Colitis - metabolism ; Colitis - pathology ; Colitis/etiology/metabolism/pathology ; Collagen ; Collagen - analysis ; collagenous colitis ; Diarrhea ; diarrhoea ; Drugs ; etiology ; Female ; Follow ; Follow-Up Studies ; Gastroenterology & hepatology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroentérologie & hépatologie ; Gluten ; Hospitals ; Human health sciences ; Humans ; Inflammatory bowel disease ; Laboratories ; lymphocytic colitis ; Lymphocytosis ; Lymphocytosis - etiology ; Lymphocytosis - pathology ; Lymphocytosis/etiology/pathology ; Male ; Medical sciences ; metabolism ; Middle Aged ; Other diseases. Semiology ; over ; pathology ; Prognosis ; Risk Factors ; Sciences de la santé humaine ; Sex Distribution ; Smoking ; Smoking - adverse effects ; Statistical analysis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Studies ; Up Studies
ispartofGut, 1999-09, Vol.45 (3), p.375-381
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descriptionBACKGROUND AND AIMS It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis.
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titleLymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis
authorBaert, F ; Wouters, K ; D’Haens, G ; Hoang, P ; Naegels, S ; D’Heygere, F ; Holvoet, J ; Louis, E ; Devos, M ; Geboes, K
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abstractBACKGROUND AND AIMS It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis.
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