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Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study

Background: Findings on the association between the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene and cardiovascular morbidity and mortality have been inconsistent. Considering the possible interaction between this polymorphism and smoking, we evaluated the... Full description

Journal Title: Journal of medical genetics 2005-01, Vol.42 (1), p.26-30
Main Author: Sayed-Tabatabaei, F A
Other Authors: Schut, A F C , Arias Vásquez, A , Bertoli-Avella, A M , Hofman, A , Witteman, J C M , van Duijn, C M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ACE
CHD
CVD
I/D
IMT
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd
ID: ISSN: 0022-2593
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1735916
title: Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study
format: Article
creator:
  • Sayed-Tabatabaei, F A
  • Schut, A F C
  • Arias Vásquez, A
  • Bertoli-Avella, A M
  • Hofman, A
  • Witteman, J C M
  • van Duijn, C M
subjects:
  • 80 and over
  • ACE
  • Aged
  • Aged, 80 and over
  • angiotensin
  • Angiotensin converting enzyme
  • angiotensin I-converting enzyme
  • Biological and medical sciences
  • Cardiology. Vascular system
  • cardiovascular disease
  • Cardiovascular Diseases
  • Cardiovascular Diseases - epidemiology
  • Cardiovascular Diseases - genetics
  • Cardiovascular Diseases - mortality
  • Cardiovascular Diseases/epidemiology/genetics/mortality
  • CHD
  • Cohort Studies
  • coronary heart disease
  • CVD
  • Dipeptidase A
  • epidemiology
  • Follow
  • Follow-Up Studies
  • General aspects. Genetic counseling
  • genes
  • Genetic
  • Genetic aspects
  • genetics
  • Genotype
  • Humans
  • I/D
  • IMT
  • insertion/deletion
  • intima media thickness
  • Introns
  • Medical genetics
  • Medical sciences
  • Middle Aged
  • Morbidity
  • mortality
  • Myocardial Infarction
  • Myocardial Infarction - epidemiology
  • Myocardial Infarction - genetics
  • Myocardial Infarction - mortality
  • Myocardial Infarction/epidemiology/genetics/mortality
  • Netherl
  • Netherlands - epidemiology
  • Original
  • Original Article
  • over
  • Peptidyl
  • Peptidyl-Dipeptidase A - genetics
  • Polymorphism
  • Polymorphism, Genetic
  • Research
  • Risk Factors
  • Smoking
  • Smoking - epidemiology
  • Time Factors
  • Up Studies
ispartof: Journal of medical genetics, 2005-01, Vol.42 (1), p.26-30
description: Background: Findings on the association between the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene and cardiovascular morbidity and mortality have been inconsistent. Considering the possible interaction between this polymorphism and smoking, we evaluated the association between ACE I/D polymorphism and myocardial infarction (MI), mortality due to coronary heart disease (CHD), and cardiovascular disease (CVD). Methods: The study was performed within the Rotterdam Study, a population based cohort study. The ACE I/D polymorphism was determined for 6714 participants and smoking status recorded at baseline. Fatal and non-fatal MIs and mortality events were regularly recorded. Cox proportional hazard analysis was performed separately for current smokers and non-smokers. We used age as the follow up time, presenting age specific survivals. Results: During follow up, 248 MIs and 301 and 482 deaths, respectively, due to CHD and CVD occurred. There were no significant differences between the genotypes as regards MI incidence. Among smokers, there was an increased risk of CHD and CVD mortality in carriers of the DD genotype compared to the II genotype, which diminished at later ages (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0022-2593
fulltext: fulltext
issn:
  • 0022-2593
  • 1468-6244
  • 1468-6244
url: Link


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titleAngiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study
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creatorSayed-Tabatabaei, F A ; Schut, A F C ; Arias Vásquez, A ; Bertoli-Avella, A M ; Hofman, A ; Witteman, J C M ; van Duijn, C M
creatorcontribSayed-Tabatabaei, F A ; Schut, A F C ; Arias Vásquez, A ; Bertoli-Avella, A M ; Hofman, A ; Witteman, J C M ; van Duijn, C M
descriptionBackground: Findings on the association between the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene and cardiovascular morbidity and mortality have been inconsistent. Considering the possible interaction between this polymorphism and smoking, we evaluated the association between ACE I/D polymorphism and myocardial infarction (MI), mortality due to coronary heart disease (CHD), and cardiovascular disease (CVD). Methods: The study was performed within the Rotterdam Study, a population based cohort study. The ACE I/D polymorphism was determined for 6714 participants and smoking status recorded at baseline. Fatal and non-fatal MIs and mortality events were regularly recorded. Cox proportional hazard analysis was performed separately for current smokers and non-smokers. We used age as the follow up time, presenting age specific survivals. Results: During follow up, 248 MIs and 301 and 482 deaths, respectively, due to CHD and CVD occurred. There were no significant differences between the genotypes as regards MI incidence. Among smokers, there was an increased risk of CHD and CVD mortality in carriers of the DD genotype compared to the II genotype, which diminished at later ages (p<0.01 for gene-age interaction). Subgroup analysis in a younger and older group (based on the median age of 68.2 years) showed a significantly increased risk of CVD mortality in the younger group (hazard ratio = 5.19; 95% confidence interval: 1.15 to 23.42). Conclusions: This study showed that the ACE I/D polymorphism is not a strong risk factor for MI but its interaction with smoking might play a role in cardiovascular mortality especially at younger ages.
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subject80 and over ; ACE ; Aged ; Aged, 80 and over ; angiotensin ; Angiotensin converting enzyme ; angiotensin I-converting enzyme ; Biological and medical sciences ; Cardiology. Vascular system ; cardiovascular disease ; Cardiovascular Diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases/epidemiology/genetics/mortality ; CHD ; Cohort Studies ; coronary heart disease ; CVD ; Dipeptidase A ; epidemiology ; Follow ; Follow-Up Studies ; General aspects. Genetic counseling ; genes ; Genetic ; Genetic aspects ; genetics ; Genotype ; Humans ; I/D ; IMT ; insertion/deletion ; intima media thickness ; Introns ; Medical genetics ; Medical sciences ; Middle Aged ; Morbidity ; mortality ; Myocardial Infarction ; Myocardial Infarction - epidemiology ; Myocardial Infarction - genetics ; Myocardial Infarction - mortality ; Myocardial Infarction/epidemiology/genetics/mortality ; Netherl ; Netherlands - epidemiology ; Original ; Original Article ; over ; Peptidyl ; Peptidyl-Dipeptidase A - genetics ; Polymorphism ; Polymorphism, Genetic ; Research ; Risk Factors ; Smoking ; Smoking - epidemiology ; Time Factors ; Up Studies
ispartofJournal of medical genetics, 2005-01, Vol.42 (1), p.26-30
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1Schut, A F C
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5Witteman, J C M
6van Duijn, C M
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0Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study
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descriptionBackground: Findings on the association between the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene and cardiovascular morbidity and mortality have been inconsistent. Considering the possible interaction between this polymorphism and smoking, we evaluated the association between ACE I/D polymorphism and myocardial infarction (MI), mortality due to coronary heart disease (CHD), and cardiovascular disease (CVD). Methods: The study was performed within the Rotterdam Study, a population based cohort study. The ACE I/D polymorphism was determined for 6714 participants and smoking status recorded at baseline. Fatal and non-fatal MIs and mortality events were regularly recorded. Cox proportional hazard analysis was performed separately for current smokers and non-smokers. We used age as the follow up time, presenting age specific survivals. Results: During follow up, 248 MIs and 301 and 482 deaths, respectively, due to CHD and CVD occurred. There were no significant differences between the genotypes as regards MI incidence. Among smokers, there was an increased risk of CHD and CVD mortality in carriers of the DD genotype compared to the II genotype, which diminished at later ages (p<0.01 for gene-age interaction). Subgroup analysis in a younger and older group (based on the median age of 68.2 years) showed a significantly increased risk of CVD mortality in the younger group (hazard ratio = 5.19; 95% confidence interval: 1.15 to 23.42). Conclusions: This study showed that the ACE I/D polymorphism is not a strong risk factor for MI but its interaction with smoking might play a role in cardiovascular mortality especially at younger ages.
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080 and over
1ACE
2Aged
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4angiotensin
5Angiotensin converting enzyme
6angiotensin I-converting enzyme
7Biological and medical sciences
8Cardiology. Vascular system
9cardiovascular disease
10Cardiovascular Diseases
11Cardiovascular Diseases - epidemiology
12Cardiovascular Diseases - genetics
13Cardiovascular Diseases - mortality
14Cardiovascular Diseases/epidemiology/genetics/mortality
15CHD
16Cohort Studies
17coronary heart disease
18CVD
19Dipeptidase A
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21Follow
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28Genotype
29Humans
30I/D
31IMT
32insertion/deletion
33intima media thickness
34Introns
35Medical genetics
36Medical sciences
37Middle Aged
38Morbidity
39mortality
40Myocardial Infarction
41Myocardial Infarction - epidemiology
42Myocardial Infarction - genetics
43Myocardial Infarction - mortality
44Myocardial Infarction/epidemiology/genetics/mortality
45Netherl
46Netherlands - epidemiology
47Original
48Original Article
49over
50Peptidyl
51Peptidyl-Dipeptidase A - genetics
52Polymorphism
53Polymorphism, Genetic
54Research
55Risk Factors
56Smoking
57Smoking - epidemiology
58Time Factors
59Up Studies
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titleAngiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study
authorSayed-Tabatabaei, F A ; Schut, A F C ; Arias Vásquez, A ; Bertoli-Avella, A M ; Hofman, A ; Witteman, J C M ; van Duijn, C M
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13Cardiovascular Diseases - mortality
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16Cohort Studies
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19Dipeptidase A
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56Smoking
57Smoking - epidemiology
58Time Factors
59Up Studies
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 F A Sayed-Tabatabaei
 Department of Epidemiology and Biostatistics, Erasmus Medical Center, Postbus 1738, 3000 DR Rotterdam, The Netherlands;f.sayed@erasmusmc.nl
abstractBackground: Findings on the association between the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene and cardiovascular morbidity and mortality have been inconsistent. Considering the possible interaction between this polymorphism and smoking, we evaluated the association between ACE I/D polymorphism and myocardial infarction (MI), mortality due to coronary heart disease (CHD), and cardiovascular disease (CVD). Methods: The study was performed within the Rotterdam Study, a population based cohort study. The ACE I/D polymorphism was determined for 6714 participants and smoking status recorded at baseline. Fatal and non-fatal MIs and mortality events were regularly recorded. Cox proportional hazard analysis was performed separately for current smokers and non-smokers. We used age as the follow up time, presenting age specific survivals. Results: During follow up, 248 MIs and 301 and 482 deaths, respectively, due to CHD and CVD occurred. There were no significant differences between the genotypes as regards MI incidence. Among smokers, there was an increased risk of CHD and CVD mortality in carriers of the DD genotype compared to the II genotype, which diminished at later ages (p<0.01 for gene-age interaction). Subgroup analysis in a younger and older group (based on the median age of 68.2 years) showed a significantly increased risk of CVD mortality in the younger group (hazard ratio = 5.19; 95% confidence interval: 1.15 to 23.42). Conclusions: This study showed that the ACE I/D polymorphism is not a strong risk factor for MI but its interaction with smoking might play a role in cardiovascular mortality especially at younger ages.
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