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fMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease

Objective: To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer’s disease by functional magnetic resonance imaging (fMRI) during an associative encoding task. Methods: 10 young controls, 10 elderly controls, and seven patients with mild Alzheimer’s diseas... Full description

Journal Title: Journal of neurology neurosurgery and psychiatry, 2003-01, Vol.74 (1), p.44-50
Main Author: Sperling, R A
Other Authors: Bates, J F , Chua, E F , Cocchiarella, A J , Rentz, D M , Rosen, B R , Schacter, D L , Albert, M S
Format: Electronic Article Electronic Article
Language: English
Subjects:
NvF
NvR
RvF
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd
ID: ISSN: 0022-3050
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1738201
title: fMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease
format: Article
creator:
  • Sperling, R A
  • Bates, J F
  • Chua, E F
  • Cocchiarella, A J
  • Rentz, D M
  • Rosen, B R
  • Schacter, D L
  • Albert, M S
subjects:
  • activities
  • Adult
  • Aged
  • Aged, 80 and over
  • aging
  • Aging - physiology
  • Alzheimer Disease - diagnosis
  • Alzheimer Disease - physiopathology
  • Alzheimer's disease
  • Alzheimer’s Disease and Related Disorders Association
  • Association
  • Association Learning
  • behavioral disciplines
  • Biological and medical sciences
  • Brain
  • Brain - pathology
  • Brain - physiology
  • Brain - physiopathology
  • Brain Mapping
  • Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
  • Diseases
  • Female
  • fMRI
  • functional magnetic resonance imaging
  • genetic structures
  • Hippocampus - pathology
  • Hippocampus - physiology
  • Hippocampus - physiopathology
  • Humans
  • magnetic resonance
  • Magnetic Resonance Imaging
  • Male
  • Medical examination
  • Medical sciences
  • memory
  • Memory Disorders - diagnosis
  • Memory Disorders - etiology
  • Memory Disorders - physiopathology
  • National Institute of Neurological and Communicative Disorders and Stroke
  • Neurology
  • NINCDS-ADRDA
  • novel v fixation
  • novel v repeated
  • NvF
  • NvR
  • Paper
  • Photic Stimulation
  • Physiological aspects
  • Predictive Value of Tests
  • processes
  • psychological phenomena
  • Reference Values
  • repeated v fixation
  • RvF
  • Usage
ispartof: Journal of neurology, neurosurgery and psychiatry, 2003-01, Vol.74 (1), p.44-50
description: Objective: To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer’s disease by functional magnetic resonance imaging (fMRI) during an associative encoding task. Methods: 10 young controls, 10 elderly controls, and seven patients with mild Alzheimer’s disease were studied using fMRI during a face–name association encoding task. The fMRI paradigm used a block design with three conditions: novel face–name pairs, repeated face–name pairs, and visual fixation. Results: The young and elderly controls differed primarily in the pattern of activation seen in prefrontal and parietal cortices: elderly controls showed significantly less activation in both superior and inferior prefrontal cortices but greater activation in parietal regions than younger controls during the encoding of novel face–name pairs. Compared with elderly controls, the Alzheimer patients showed significantly less activation in the hippocampal formation but greater activation in the medial parietal and posterior cingulate regions. Conclusions: The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer’s disease compared with normal aging.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0022-3050
fulltext: fulltext
issn:
  • 0022-3050
  • 1468-330X
url: Link


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descriptionObjective: To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer’s disease by functional magnetic resonance imaging (fMRI) during an associative encoding task. Methods: 10 young controls, 10 elderly controls, and seven patients with mild Alzheimer’s disease were studied using fMRI during a face–name association encoding task. The fMRI paradigm used a block design with three conditions: novel face–name pairs, repeated face–name pairs, and visual fixation. Results: The young and elderly controls differed primarily in the pattern of activation seen in prefrontal and parietal cortices: elderly controls showed significantly less activation in both superior and inferior prefrontal cortices but greater activation in parietal regions than younger controls during the encoding of novel face–name pairs. Compared with elderly controls, the Alzheimer patients showed significantly less activation in the hippocampal formation but greater activation in the medial parietal and posterior cingulate regions. Conclusions: The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer’s disease compared with normal aging.
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subjectactivities ; Adult ; Aged ; Aged, 80 and over ; aging ; Aging - physiology ; Alzheimer Disease - diagnosis ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Alzheimer’s Disease and Related Disorders Association ; Association ; Association Learning ; behavioral disciplines ; Biological and medical sciences ; Brain ; Brain - pathology ; Brain - physiology ; Brain - physiopathology ; Brain Mapping ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diseases ; Female ; fMRI ; functional magnetic resonance imaging ; genetic structures ; Hippocampus - pathology ; Hippocampus - physiology ; Hippocampus - physiopathology ; Humans ; magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical examination ; Medical sciences ; memory ; Memory Disorders - diagnosis ; Memory Disorders - etiology ; Memory Disorders - physiopathology ; National Institute of Neurological and Communicative Disorders and Stroke ; Neurology ; NINCDS-ADRDA ; novel v fixation ; novel v repeated ; NvF ; NvR ; Paper ; Photic Stimulation ; Physiological aspects ; Predictive Value of Tests ; processes ; psychological phenomena ; Reference Values ; repeated v fixation ; RvF ; Usage
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1Bates, J F
2Chua, E F
3Cocchiarella, A J
4Rentz, D M
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7Albert, M S
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descriptionObjective: To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer’s disease by functional magnetic resonance imaging (fMRI) during an associative encoding task. Methods: 10 young controls, 10 elderly controls, and seven patients with mild Alzheimer’s disease were studied using fMRI during a face–name association encoding task. The fMRI paradigm used a block design with three conditions: novel face–name pairs, repeated face–name pairs, and visual fixation. Results: The young and elderly controls differed primarily in the pattern of activation seen in prefrontal and parietal cortices: elderly controls showed significantly less activation in both superior and inferior prefrontal cortices but greater activation in parietal regions than younger controls during the encoding of novel face–name pairs. Compared with elderly controls, the Alzheimer patients showed significantly less activation in the hippocampal formation but greater activation in the medial parietal and posterior cingulate regions. Conclusions: The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer’s disease compared with normal aging.
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0Sperling, R A
1Bates, J F
2Chua, E F
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4Rentz, D M
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atitlefMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease
jtitleJournal of neurology, neurosurgery and psychiatry
addtitleJ Neurol Neurosurg Psychiatry
date2003-01
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volume74
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pages44-50
issn0022-3050
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codenJNNPAU
notesCorrespondence to:
 Dr Reisa Sperling, 221 Longwood Avenue, Boston, MA 02115, USA; 
 reisa@rics.bwh.harvard.edu
abstractObjective: To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer’s disease by functional magnetic resonance imaging (fMRI) during an associative encoding task. Methods: 10 young controls, 10 elderly controls, and seven patients with mild Alzheimer’s disease were studied using fMRI during a face–name association encoding task. The fMRI paradigm used a block design with three conditions: novel face–name pairs, repeated face–name pairs, and visual fixation. Results: The young and elderly controls differed primarily in the pattern of activation seen in prefrontal and parietal cortices: elderly controls showed significantly less activation in both superior and inferior prefrontal cortices but greater activation in parietal regions than younger controls during the encoding of novel face–name pairs. Compared with elderly controls, the Alzheimer patients showed significantly less activation in the hippocampal formation but greater activation in the medial parietal and posterior cingulate regions. Conclusions: The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer’s disease compared with normal aging.
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