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A longitudinal cohort study of Finnish patients with primary Sjögren's syndrome: clinical, immunological, and epidemiological aspects

OBJECTIVE To evaluate outcome in a cohort of Finnish patients with primary Sjögren's syndrome (pSS). METHODS Clinical and laboratory data from the time of diagnosis and follow up were collected from 110 patients with pSS (107 women, three men) diagnosed in 1977–1992 in central Finland. The standardi... Full description

Journal Title: Annals of the rheumatic diseases 2001-05, Vol.60 (5), p.467-472
Main Author: Pertovaara, M
Other Authors: Pukkala, E , Laippala, P , Miettinen, A , Pasternack, A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and European League Against Rheumatism
ID: ISSN: 0003-4967
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1753646
title: A longitudinal cohort study of Finnish patients with primary Sjögren's syndrome: clinical, immunological, and epidemiological aspects
format: Article
creator:
  • Pertovaara, M
  • Pukkala, E
  • Laippala, P
  • Miettinen, A
  • Pasternack, A
subjects:
  • Aged
  • Analysis
  • beta 2-Microglobulin - analysis
  • Biological and medical sciences
  • Biomarkers - blood
  • Cause of Death
  • Extended Report
  • Female
  • Finland - epidemiology
  • follow up studies
  • Hospitals
  • Humans
  • Immunology
  • Incidence
  • Internal medicine
  • Laboratories
  • Logistic Models
  • Longitudinal Studies
  • Lymphoma
  • Lymphoma, Non-Hodgkin - blood
  • Lymphoma, Non-Hodgkin - complications
  • Male
  • Medical sciences
  • Middle Aged
  • Mortality
  • non-Hodgkin's lymphoma
  • Outcome and process assessment (Health Care)
  • Population
  • Prognosis
  • Rheumatology
  • Risk
  • Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
  • Sjogren's syndrome
  • Sjogren's Syndrome - blood
  • Sjogren's Syndrome - complications
  • Sjogren's Syndrome - epidemiology
  • Sjögren's syndrome
  • Statistics, Nonparametric
  • β2microglobulin
ispartof: Annals of the rheumatic diseases, 2001-05, Vol.60 (5), p.467-472
description: OBJECTIVE To evaluate outcome in a cohort of Finnish patients with primary Sjögren's syndrome (pSS). METHODS Clinical and laboratory data from the time of diagnosis and follow up were collected from 110 patients with pSS (107 women, three men) diagnosed in 1977–1992 in central Finland. The standardised incidence ratio for cancers was determined as the ratio of the observed number of cases to the expected number based on regional population rates. Eighty one of the 93 patients still alive were interviewed, and clinical and laboratory examinations performed in 1994–1997. RESULTS The mean (SD) erythrocyte sedimentation rate (33 (22) v 45 (28) mm/1st h), serum IgG (18.8 (7.4) v 22.5 (8.5) g/l), and serum IgM (1.6 (1.1) v 2.0 (1.2) g/l) at the control visit were significantly (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0003-4967
fulltext: fulltext
issn:
  • 0003-4967
  • 1468-2060
url: Link


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descriptionOBJECTIVE To evaluate outcome in a cohort of Finnish patients with primary Sjögren's syndrome (pSS). METHODS Clinical and laboratory data from the time of diagnosis and follow up were collected from 110 patients with pSS (107 women, three men) diagnosed in 1977–1992 in central Finland. The standardised incidence ratio for cancers was determined as the ratio of the observed number of cases to the expected number based on regional population rates. Eighty one of the 93 patients still alive were interviewed, and clinical and laboratory examinations performed in 1994–1997. RESULTS The mean (SD) erythrocyte sedimentation rate (33 (22) v 45 (28) mm/1st h), serum IgG (18.8 (7.4) v 22.5 (8.5) g/l), and serum IgM (1.6 (1.1) v 2.0 (1.2) g/l) at the control visit were significantly (p<0.0001) lower than those at baseline. A similar change was observed in a subgroup of patients never treated with glucocorticosteroids or disease modifying antirheumatic drugs. Three non-Hodgkin's lymphomas were diagnosed (standardised incidence ratio 13; 95% confidence interval 2.7 to 38). In a logistic regression model, the patients with pSS with subsequent lymphoma were found to have higher baseline levels of serum β2 microglobulin than the others (odds ratio 1.9; 95% confidence interval 1.1 to 3.4). CONCLUSION The results suggest that mean concentrations of serum IgG and IgM in patients with pSS decline with time, possibly reflecting diminishing inflammatory activity. As in previous studies, the incidence of non-Hodgkin's lymphomas in this cohort of patients with pSS was significantly higher than in the reference population.
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subjectAged ; Analysis ; beta 2-Microglobulin - analysis ; Biological and medical sciences ; Biomarkers - blood ; Cause of Death ; Extended Report ; Female ; Finland - epidemiology ; follow up studies ; Hospitals ; Humans ; Immunology ; Incidence ; Internal medicine ; Laboratories ; Logistic Models ; Longitudinal Studies ; Lymphoma ; Lymphoma, Non-Hodgkin - blood ; Lymphoma, Non-Hodgkin - complications ; Male ; Medical sciences ; Middle Aged ; Mortality ; non-Hodgkin's lymphoma ; Outcome and process assessment (Health Care) ; Population ; Prognosis ; Rheumatology ; Risk ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sjogren's syndrome ; Sjogren's Syndrome - blood ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - epidemiology ; Sjögren's syndrome ; Statistics, Nonparametric ; β2microglobulin
ispartofAnnals of the rheumatic diseases, 2001-05, Vol.60 (5), p.467-472
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descriptionOBJECTIVE To evaluate outcome in a cohort of Finnish patients with primary Sjögren's syndrome (pSS). METHODS Clinical and laboratory data from the time of diagnosis and follow up were collected from 110 patients with pSS (107 women, three men) diagnosed in 1977–1992 in central Finland. The standardised incidence ratio for cancers was determined as the ratio of the observed number of cases to the expected number based on regional population rates. Eighty one of the 93 patients still alive were interviewed, and clinical and laboratory examinations performed in 1994–1997. RESULTS The mean (SD) erythrocyte sedimentation rate (33 (22) v 45 (28) mm/1st h), serum IgG (18.8 (7.4) v 22.5 (8.5) g/l), and serum IgM (1.6 (1.1) v 2.0 (1.2) g/l) at the control visit were significantly (p<0.0001) lower than those at baseline. A similar change was observed in a subgroup of patients never treated with glucocorticosteroids or disease modifying antirheumatic drugs. Three non-Hodgkin's lymphomas were diagnosed (standardised incidence ratio 13; 95% confidence interval 2.7 to 38). In a logistic regression model, the patients with pSS with subsequent lymphoma were found to have higher baseline levels of serum β2 microglobulin than the others (odds ratio 1.9; 95% confidence interval 1.1 to 3.4). CONCLUSION The results suggest that mean concentrations of serum IgG and IgM in patients with pSS decline with time, possibly reflecting diminishing inflammatory activity. As in previous studies, the incidence of non-Hodgkin's lymphomas in this cohort of patients with pSS was significantly higher than in the reference population.
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8Finland - epidemiology
9follow up studies
10Hospitals
11Humans
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18Lymphoma
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20Lymphoma, Non-Hodgkin - complications
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38β2microglobulin
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abstractOBJECTIVE To evaluate outcome in a cohort of Finnish patients with primary Sjögren's syndrome (pSS). METHODS Clinical and laboratory data from the time of diagnosis and follow up were collected from 110 patients with pSS (107 women, three men) diagnosed in 1977–1992 in central Finland. The standardised incidence ratio for cancers was determined as the ratio of the observed number of cases to the expected number based on regional population rates. Eighty one of the 93 patients still alive were interviewed, and clinical and laboratory examinations performed in 1994–1997. RESULTS The mean (SD) erythrocyte sedimentation rate (33 (22) v 45 (28) mm/1st h), serum IgG (18.8 (7.4) v 22.5 (8.5) g/l), and serum IgM (1.6 (1.1) v 2.0 (1.2) g/l) at the control visit were significantly (p<0.0001) lower than those at baseline. A similar change was observed in a subgroup of patients never treated with glucocorticosteroids or disease modifying antirheumatic drugs. Three non-Hodgkin's lymphomas were diagnosed (standardised incidence ratio 13; 95% confidence interval 2.7 to 38). In a logistic regression model, the patients with pSS with subsequent lymphoma were found to have higher baseline levels of serum β2 microglobulin than the others (odds ratio 1.9; 95% confidence interval 1.1 to 3.4). CONCLUSION The results suggest that mean concentrations of serum IgG and IgM in patients with pSS decline with time, possibly reflecting diminishing inflammatory activity. As in previous studies, the incidence of non-Hodgkin's lymphomas in this cohort of patients with pSS was significantly higher than in the reference population.
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