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Spatiotemporal Asymmetry of Associative Synaptic Plasticity in Fear Conditioning Pathways

Input-specific long-term potentiation (LTP) in afferent inputs to the amygdala serves an essential function in the acquisition of fear memory. Factors underlying input specificity of synaptic modifications implicated in information transfer in fear conditioning pathways remain unclear. Here we show... Full description

Journal Title: Neuron 2006, Vol.52 (5), p.883-896
Main Author: Shin, Ryong-Moon
Other Authors: Tsvetkov, Evgeny , Bolshakov, Vadim Y
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
Link: https://www.ncbi.nlm.nih.gov/pubmed/17145508
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1764975
title: Spatiotemporal Asymmetry of Associative Synaptic Plasticity in Fear Conditioning Pathways
format: Article
creator:
  • Shin, Ryong-Moon
  • Tsvetkov, Evgeny
  • Bolshakov, Vadim Y
subjects:
  • Action Potentials - physiology
  • Amygdala - physiology
  • Animals
  • Article
  • Brain
  • Cerebral Cortex - physiology
  • Conditioning (Psychology) - physiology
  • Electrophysiology
  • Excitatory Postsynaptic Potentials - physiology
  • Experiments
  • Fear - physiology
  • Glutamates - physiology
  • In Vitro Techniques
  • Interneurons - physiology
  • Long-Term Potentiation - physiology
  • Memory - physiology
  • nervous system
  • Neural Pathways - cytology
  • Neural Pathways - physiology
  • Neuronal Plasticity - physiology
  • Neurons
  • Neurons, Afferent - physiology
  • Neuroscience(all)
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate - physiology
  • Rodents
  • SIGNALING
  • Synapses - physiology
  • Synaptic Transmission - physiology
  • SYSNEURO
  • Thalamus - physiology
ispartof: Neuron, 2006, Vol.52 (5), p.883-896
description: Input-specific long-term potentiation (LTP) in afferent inputs to the amygdala serves an essential function in the acquisition of fear memory. Factors underlying input specificity of synaptic modifications implicated in information transfer in fear conditioning pathways remain unclear. Here we show that the strength of naive synapses in two auditory inputs converging on a single neuron in the lateral nucleus of the amygdala (LA) is only modified when a postsynaptic action potential closely follows a synaptic response. The stronger inhibitory drive in thalamic pathway, as compared with cortical input, hampers the induction of LTP at thalamo-amygdala synapses, contributing to the spatial specificity of LTP in convergent inputs. These results indicate that spike timing-dependent synaptic plasticity in afferent projections to the LA is both temporarily and spatially asymmetric, thus providing a mechanism for the conditioned stimulus discrimination during fear behavior.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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descriptionInput-specific long-term potentiation (LTP) in afferent inputs to the amygdala serves an essential function in the acquisition of fear memory. Factors underlying input specificity of synaptic modifications implicated in information transfer in fear conditioning pathways remain unclear. Here we show that the strength of naive synapses in two auditory inputs converging on a single neuron in the lateral nucleus of the amygdala (LA) is only modified when a postsynaptic action potential closely follows a synaptic response. The stronger inhibitory drive in thalamic pathway, as compared with cortical input, hampers the induction of LTP at thalamo-amygdala synapses, contributing to the spatial specificity of LTP in convergent inputs. These results indicate that spike timing-dependent synaptic plasticity in afferent projections to the LA is both temporarily and spatially asymmetric, thus providing a mechanism for the conditioned stimulus discrimination during fear behavior.
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subjectAction Potentials - physiology ; Amygdala - physiology ; Animals ; Article ; Brain ; Cerebral Cortex - physiology ; Conditioning (Psychology) - physiology ; Electrophysiology ; Excitatory Postsynaptic Potentials - physiology ; Experiments ; Fear - physiology ; Glutamates - physiology ; In Vitro Techniques ; Interneurons - physiology ; Long-Term Potentiation - physiology ; Memory - physiology ; nervous system ; Neural Pathways - cytology ; Neural Pathways - physiology ; Neuronal Plasticity - physiology ; Neurons ; Neurons, Afferent - physiology ; Neuroscience(all) ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate - physiology ; Rodents ; SIGNALING ; Synapses - physiology ; Synaptic Transmission - physiology ; SYSNEURO ; Thalamus - physiology
ispartofNeuron, 2006, Vol.52 (5), p.883-896
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abstractInput-specific long-term potentiation (LTP) in afferent inputs to the amygdala serves an essential function in the acquisition of fear memory. Factors underlying input specificity of synaptic modifications implicated in information transfer in fear conditioning pathways remain unclear. Here we show that the strength of naive synapses in two auditory inputs converging on a single neuron in the lateral nucleus of the amygdala (LA) is only modified when a postsynaptic action potential closely follows a synaptic response. The stronger inhibitory drive in thalamic pathway, as compared with cortical input, hampers the induction of LTP at thalamo-amygdala synapses, contributing to the spatial specificity of LTP in convergent inputs. These results indicate that spike timing-dependent synaptic plasticity in afferent projections to the LA is both temporarily and spatially asymmetric, thus providing a mechanism for the conditioned stimulus discrimination during fear behavior.
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