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Cardiac structural and functional abnormalities in end stage renal disease patients with elevated cardiac troponin T

Objectives: To identify in a prospective observational study the cardiac structural and functional abnormalities and mortality in patients with end stage renal disease (ESRD) with a raised cardiac troponin T (cTnT) concentration. Methods: 126 renal transplant candidates were studied over a two year... Full description

Journal Title: Heart (British Cardiac Society) 2006, Vol.92 (6), p.804-809
Main Author: Sharma, R
Other Authors: Gaze, D C , Pellerin, D , Mehta, R L , Gregson, H , Streather, C P , Collinson, P O , Brecker, S J D
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
Biological and medical sciences
BNP
brain natriuretic peptide
CAD
Cardiac arrhythmia
cardiac structure
cardiac troponin T
Cardiology. Vascular system
Cardiomyopathy, Dilated - metabolism
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Medicine
Chronic kidney failure
coronary artery disease
cTnT
Diabetes
Diabetic Angiopathies - metabolism
dobutamine stress echocardiography
DSE
Echocardiography
Echocardiography, Stress
end stage renal disease
ESRD
Female
Heart attacks
Heart Diseases - mortality
Heart Diseases - pathology
Heart Diseases - physiopathology
Heart rate
Hemodialysis
Humans
Kidney diseases
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - mortality
left ventricular
left ventricular ejection fraction
left ventricular mass index
LV
LVEF
LVMI
Male
Medical imaging
Medical sciences
Middle Aged
Mortality
N-terminal pro-B-type natriuretic peptide
Natriuretic Peptide, Brain - metabolism
NT-proBNP
Patient outcomes
Patients
Peptide Fragments - metabolism
propagation velocity
Prospective Studies
renal failure
Risk factors
Studies
Transplants & implants
Troponin T - metabolism
Ventricular Dysfunction, Left - metabolism
Vp
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 1355-6037
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1860676
title: Cardiac structural and functional abnormalities in end stage renal disease patients with elevated cardiac troponin T
format: Article
creator:
  • Sharma, R
  • Gaze, D C
  • Pellerin, D
  • Mehta, R L
  • Gregson, H
  • Streather, C P
  • Collinson, P O
  • Brecker, S J D
subjects:
  • Abridged Index Medicus
  • Biological and medical sciences
  • BNP
  • brain natriuretic peptide
  • CAD
  • Cardiac arrhythmia
  • cardiac structure
  • cardiac troponin T
  • Cardiology. Vascular system
  • Cardiomyopathy, Dilated - metabolism
  • Cardiovascular disease
  • Cardiovascular diseases
  • Cardiovascular Medicine
  • Chronic kidney failure
  • coronary artery disease
  • cTnT
  • Diabetes
  • Diabetic Angiopathies - metabolism
  • dobutamine stress echocardiography
  • DSE
  • Echocardiography
  • Echocardiography, Stress
  • end stage renal disease
  • ESRD
  • Female
  • Heart attacks
  • Heart Diseases - mortality
  • Heart Diseases - pathology
  • Heart Diseases - physiopathology
  • Heart rate
  • Hemodialysis
  • Humans
  • Kidney diseases
  • Kidney Failure, Chronic - complications
  • Kidney Failure, Chronic - mortality
  • left ventricular
  • left ventricular ejection fraction
  • left ventricular mass index
  • LV
  • LVEF
  • LVMI
  • Male
  • Medical imaging
  • Medical sciences
  • Middle Aged
  • Mortality
  • N-terminal pro-B-type natriuretic peptide
  • Natriuretic Peptide, Brain - metabolism
  • NT-proBNP
  • Patient outcomes
  • Patients
  • Peptide Fragments - metabolism
  • propagation velocity
  • Prospective Studies
  • renal failure
  • Risk factors
  • Studies
  • Transplants & implants
  • Troponin T - metabolism
  • Ventricular Dysfunction, Left - metabolism
  • Vp
ispartof: Heart (British Cardiac Society), 2006, Vol.92 (6), p.804-809
description: Objectives: To identify in a prospective observational study the cardiac structural and functional abnormalities and mortality in patients with end stage renal disease (ESRD) with a raised cardiac troponin T (cTnT) concentration. Methods: 126 renal transplant candidates were studied over a two year period. Clinical, biochemical, echocardiographic, coronary angiographic, and dobutamine stress echocardiographic (DSE) data were examined in comparison with cTnT concentrations dichotomised at cut off concentrations of < 0.04 μg/l and < 0.10 μg/l. Results: Left ventricular (LV) size and filling pressure were significantly raised and LV systolic and diastolic function parameters significantly impaired in patients with raised cTnT, irrespective of the cut off concentration. The proportions of patients with diabetes and on dialysis were higher in both groups with raised cTnT. With a cut off cTnT concentration of 0.04 μg/l but not 0.10 μg/l, significantly more patients had severe coronary artery disease and a positive DSE result. The total ischaemic burden during DSE was similar in cTnT positive and negative patients, irrespective of the cut off concentration used. LV end systolic diameter index and E:Ea ratio were independent predictors of cTnT rises ⩾ 0.04 μg/l and ⩾ 0.10 μg/l, respectively. Diabetes was independently associated with cTnT at both cut off concentrations. Mortality was higher in all patients with raised cTnT. Conclusions: Patients with ESRD with raised cTnT concentrations have increased mortality. Raised concentrations are strongly associated with diabetes, LV dilatation, and impaired LV systolic and diastolic function, but not with severe coronary artery disease.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


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creatorSharma, R ; Gaze, D C ; Pellerin, D ; Mehta, R L ; Gregson, H ; Streather, C P ; Collinson, P O ; Brecker, S J D
creatorcontribSharma, R ; Gaze, D C ; Pellerin, D ; Mehta, R L ; Gregson, H ; Streather, C P ; Collinson, P O ; Brecker, S J D
descriptionObjectives: To identify in a prospective observational study the cardiac structural and functional abnormalities and mortality in patients with end stage renal disease (ESRD) with a raised cardiac troponin T (cTnT) concentration. Methods: 126 renal transplant candidates were studied over a two year period. Clinical, biochemical, echocardiographic, coronary angiographic, and dobutamine stress echocardiographic (DSE) data were examined in comparison with cTnT concentrations dichotomised at cut off concentrations of < 0.04 μg/l and < 0.10 μg/l. Results: Left ventricular (LV) size and filling pressure were significantly raised and LV systolic and diastolic function parameters significantly impaired in patients with raised cTnT, irrespective of the cut off concentration. The proportions of patients with diabetes and on dialysis were higher in both groups with raised cTnT. With a cut off cTnT concentration of 0.04 μg/l but not 0.10 μg/l, significantly more patients had severe coronary artery disease and a positive DSE result. The total ischaemic burden during DSE was similar in cTnT positive and negative patients, irrespective of the cut off concentration used. LV end systolic diameter index and E:Ea ratio were independent predictors of cTnT rises ⩾ 0.04 μg/l and ⩾ 0.10 μg/l, respectively. Diabetes was independently associated with cTnT at both cut off concentrations. Mortality was higher in all patients with raised cTnT. Conclusions: Patients with ESRD with raised cTnT concentrations have increased mortality. Raised concentrations are strongly associated with diabetes, LV dilatation, and impaired LV systolic and diastolic function, but not with severe coronary artery disease.
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0ISSN: 1355-6037
1EISSN: 1468-201X
2DOI: 10.1136/hrt.2005.069666
3PMID: 16216854
languageeng
publisherLondon: BMJ Publishing Group Ltd and British Cardiovascular Society
subjectAbridged Index Medicus ; Biological and medical sciences ; BNP ; brain natriuretic peptide ; CAD ; Cardiac arrhythmia ; cardiac structure ; cardiac troponin T ; Cardiology. Vascular system ; Cardiomyopathy, Dilated - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Medicine ; Chronic kidney failure ; coronary artery disease ; cTnT ; Diabetes ; Diabetic Angiopathies - metabolism ; dobutamine stress echocardiography ; DSE ; Echocardiography ; Echocardiography, Stress ; end stage renal disease ; ESRD ; Female ; Heart attacks ; Heart Diseases - mortality ; Heart Diseases - pathology ; Heart Diseases - physiopathology ; Heart rate ; Hemodialysis ; Humans ; Kidney diseases ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - mortality ; left ventricular ; left ventricular ejection fraction ; left ventricular mass index ; LV ; LVEF ; LVMI ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; Mortality ; N-terminal pro-B-type natriuretic peptide ; Natriuretic Peptide, Brain - metabolism ; NT-proBNP ; Patient outcomes ; Patients ; Peptide Fragments - metabolism ; propagation velocity ; Prospective Studies ; renal failure ; Risk factors ; Studies ; Transplants & implants ; Troponin T - metabolism ; Ventricular Dysfunction, Left - metabolism ; Vp
ispartofHeart (British Cardiac Society), 2006, Vol.92 (6), p.804-809
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1Gaze, D C
2Pellerin, D
3Mehta, R L
4Gregson, H
5Streather, C P
6Collinson, P O
7Brecker, S J D
title
0Cardiac structural and functional abnormalities in end stage renal disease patients with elevated cardiac troponin T
1Heart (British Cardiac Society)
addtitleHeart
descriptionObjectives: To identify in a prospective observational study the cardiac structural and functional abnormalities and mortality in patients with end stage renal disease (ESRD) with a raised cardiac troponin T (cTnT) concentration. Methods: 126 renal transplant candidates were studied over a two year period. Clinical, biochemical, echocardiographic, coronary angiographic, and dobutamine stress echocardiographic (DSE) data were examined in comparison with cTnT concentrations dichotomised at cut off concentrations of < 0.04 μg/l and < 0.10 μg/l. Results: Left ventricular (LV) size and filling pressure were significantly raised and LV systolic and diastolic function parameters significantly impaired in patients with raised cTnT, irrespective of the cut off concentration. The proportions of patients with diabetes and on dialysis were higher in both groups with raised cTnT. With a cut off cTnT concentration of 0.04 μg/l but not 0.10 μg/l, significantly more patients had severe coronary artery disease and a positive DSE result. The total ischaemic burden during DSE was similar in cTnT positive and negative patients, irrespective of the cut off concentration used. LV end systolic diameter index and E:Ea ratio were independent predictors of cTnT rises ⩾ 0.04 μg/l and ⩾ 0.10 μg/l, respectively. Diabetes was independently associated with cTnT at both cut off concentrations. Mortality was higher in all patients with raised cTnT. Conclusions: Patients with ESRD with raised cTnT concentrations have increased mortality. Raised concentrations are strongly associated with diabetes, LV dilatation, and impaired LV systolic and diastolic function, but not with severe coronary artery disease.
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0Abridged Index Medicus
1Biological and medical sciences
2BNP
3brain natriuretic peptide
4CAD
5Cardiac arrhythmia
6cardiac structure
7cardiac troponin T
8Cardiology. Vascular system
9Cardiomyopathy, Dilated - metabolism
10Cardiovascular disease
11Cardiovascular diseases
12Cardiovascular Medicine
13Chronic kidney failure
14coronary artery disease
15cTnT
16Diabetes
17Diabetic Angiopathies - metabolism
18dobutamine stress echocardiography
19DSE
20Echocardiography
21Echocardiography, Stress
22end stage renal disease
23ESRD
24Female
25Heart attacks
26Heart Diseases - mortality
27Heart Diseases - pathology
28Heart Diseases - physiopathology
29Heart rate
30Hemodialysis
31Humans
32Kidney diseases
33Kidney Failure, Chronic - complications
34Kidney Failure, Chronic - mortality
35left ventricular
36left ventricular ejection fraction
37left ventricular mass index
38LV
39LVEF
40LVMI
41Male
42Medical imaging
43Medical sciences
44Middle Aged
45Mortality
46N-terminal pro-B-type natriuretic peptide
47Natriuretic Peptide, Brain - metabolism
48NT-proBNP
49Patient outcomes
50Patients
51Peptide Fragments - metabolism
52propagation velocity
53Prospective Studies
54renal failure
55Risk factors
56Studies
57Transplants & implants
58Troponin T - metabolism
59Ventricular Dysfunction, Left - metabolism
60Vp
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authorSharma, R ; Gaze, D C ; Pellerin, D ; Mehta, R L ; Gregson, H ; Streather, C P ; Collinson, P O ; Brecker, S J D
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8Cardiology. Vascular system
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55Risk factors
56Studies
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58Troponin T - metabolism
59Ventricular Dysfunction, Left - metabolism
60Vp
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0href:heartjnl-92-804.pdf
1Correspondence to:
 Dr Rajan Sharma
 Wessex Cardiothoracic Unit, Southampton General Hospital, Southampton SO16 6YD, UK; rajdoc.Sharma@tiscali.co.uk
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abstractObjectives: To identify in a prospective observational study the cardiac structural and functional abnormalities and mortality in patients with end stage renal disease (ESRD) with a raised cardiac troponin T (cTnT) concentration. Methods: 126 renal transplant candidates were studied over a two year period. Clinical, biochemical, echocardiographic, coronary angiographic, and dobutamine stress echocardiographic (DSE) data were examined in comparison with cTnT concentrations dichotomised at cut off concentrations of < 0.04 μg/l and < 0.10 μg/l. Results: Left ventricular (LV) size and filling pressure were significantly raised and LV systolic and diastolic function parameters significantly impaired in patients with raised cTnT, irrespective of the cut off concentration. The proportions of patients with diabetes and on dialysis were higher in both groups with raised cTnT. With a cut off cTnT concentration of 0.04 μg/l but not 0.10 μg/l, significantly more patients had severe coronary artery disease and a positive DSE result. The total ischaemic burden during DSE was similar in cTnT positive and negative patients, irrespective of the cut off concentration used. LV end systolic diameter index and E:Ea ratio were independent predictors of cTnT rises ⩾ 0.04 μg/l and ⩾ 0.10 μg/l, respectively. Diabetes was independently associated with cTnT at both cut off concentrations. Mortality was higher in all patients with raised cTnT. Conclusions: Patients with ESRD with raised cTnT concentrations have increased mortality. Raised concentrations are strongly associated with diabetes, LV dilatation, and impaired LV systolic and diastolic function, but not with severe coronary artery disease.
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pmid16216854
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