schliessen

Filtern

 

Bibliotheken

A haplotype map of the human genome

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in... Full description

Journal Title: Nature 2005, Vol.437 (7063), p.1299-1320
Main Author: Willis, Td
Other Authors: Yang, H. , Hu, H. , Yu, F. , Wheeler, Da , Leal, Sm , Fulton, Ll , Clarke, G. , Mullikin, Jc , Clayton, Ew , Rogers, J. , Kato, K. , Niikawa, N. , Wang, J. , Jamieson, R. , Hudson, Tj , Barry, R. , Camargo, A. , Whittaker, P. , Defelice, M. , Frazer, Ka , Daly, Mj , Gupta, S. , Nkwodimmah, C. , Ajayi, I. , Yakub, I. , Cai, D. , Lin, S. , Kashuk, Cs , Cutler, Dj , Koboldt, Dc , Miller, Rd , Roy, J. , Winchester, E. , Bentley, Dr , Sham, Pc , Song, Yq , Maller, J. , He, Y. , Chu, X. , Smith, Av , Krishnan, L. , Stein, Ld , Schaffner, Sf , Fukushima, Y. , Shen, Y. , Ziaugra, L. , Yao, Z. , Purcell, S. , Pe Er, I. , Dermitzakis, Et , Mccarroll, S. , Deloukas, P. , Macer, Dr , Huang, W. , Suda, E. , Nagashima, A. , Nazareth, L. , Carter, Np , Weir, Bs , Morris, Ap , Donnelly, P. , Clee, Cm , Griffiths, M. , Pan, H. , Sherry, St , Hunt, S. , Myers, S. , Godbout, M. , L Archevêque, P. , Wang, Y. , Zhang, Q. , Sun, W. , Li, Q. , Wang, R. , Xu, L. , Tsui, Skw , Xue, H. , Barrett, J. , Yu, J. , Holden, Al , Feolo, M. , Murray, Ss , Wang, Vo , Chee, Ms , Peterson, Jl , Ferretti, V. , Leboeuf, M. , Shi, M. , Spiegel, J. , Phillips, Ms , Sung, Lm , Stranger, Be , Weinstock, Gm , Zacharia, Lf , Mcvean, G. , Thomas, Dj , Fry, B. , Roumy, S. , Kennedy, K.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: Nature Publishing
ID: ISSN: 0028-0836
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1880871
title: A haplotype map of the human genome
format: Article
creator:
  • Willis, Td
  • Yang, H.
  • Hu, H.
  • Yu, F.
  • Wheeler, Da
  • Leal, Sm
  • Fulton, Ll
  • Clarke, G.
  • Mullikin, Jc
  • Clayton, Ew
  • Rogers, J.
  • Kato, K.
  • Niikawa, N.
  • Wang, J.
  • Jamieson, R.
  • Hudson, Tj
  • Barry, R.
  • Camargo, A.
  • Whittaker, P.
  • Defelice, M.
  • Frazer, Ka
  • Daly, Mj
  • Gupta, S.
  • Nkwodimmah, C.
  • Ajayi, I.
  • Yakub, I.
  • Cai, D.
  • Lin, S.
  • Kashuk, Cs
  • Cutler, Dj
  • Koboldt, Dc
  • Miller, Rd
  • Roy, J.
  • Winchester, E.
  • Bentley, Dr
  • Sham, Pc
  • Song, Yq
  • Maller, J.
  • He, Y.
  • Chu, X.
  • Smith, Av
  • Krishnan, L.
  • Stein, Ld
  • Schaffner, Sf
  • Fukushima, Y.
  • Shen, Y.
  • Ziaugra, L.
  • Yao, Z.
  • Purcell, S.
  • Pe Er, I.
  • Dermitzakis, Et
  • Mccarroll, S.
  • Deloukas, P.
  • Macer, Dr
  • Huang, W.
  • Suda, E.
  • Nagashima, A.
  • Nazareth, L.
  • Carter, Np
  • Weir, Bs
  • Morris, Ap
  • Donnelly, P.
  • Clee, Cm
  • Griffiths, M.
  • Pan, H.
  • Sherry, St
  • Hunt, S.
  • Myers, S.
  • Godbout, M.
  • L Archevêque, P.
  • Wang, Y.
  • Zhang, Q.
  • Sun, W.
  • Li, Q.
  • Wang, R.
  • Xu, L.
  • Tsui, Skw
  • Xue, H.
  • Barrett, J.
  • Yu, J.
  • Holden, Al
  • Feolo, M.
  • Murray, Ss
  • Wang, Vo
  • Chee, Ms
  • Peterson, Jl
  • Ferretti, V.
  • Leboeuf, M.
  • Shi, M.
  • Spiegel, J.
  • Phillips, Ms
  • Sung, Lm
  • Stranger, Be
  • Weinstock, Gm
  • Zacharia, Lf
  • Mcvean, G.
  • Thomas, Dj
  • Fry, B.
  • Roumy, S.
  • Kennedy, K.
subjects:
  • Article
  • Biological and medical sciences
  • Chromosomes
  • Chromosomes, Human, Y - genetics
  • DNA, Mitochondrial - genetics
  • Fundamental and applied biological sciences. Psychology
  • Gene Frequency - genetics
  • genetics
  • Genetics of eukaryotes. Biological and molecular evolution
  • Genome
  • Genome, Human
  • Haplotypes
  • Haplotypes - genetics
  • Human
  • Humans
  • Linkage Disequilibrium - genetics
  • Mitochondrial
  • Polymorphism
  • Polymorphism, Single Nucleotide - genetics
  • Recombination, Genetic - genetics
  • Selection, Genetic
  • Single Nucleotide
ispartof: Nature, 2005, Vol.437 (7063), p.1299-1320
description: Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution.
language: eng
source:
identifier: ISSN: 0028-0836
fulltext: no_fulltext
issn:
  • 0028-0836
  • 1476-4687
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.7154753
LOCALfalse
PrimoNMBib
record
control
sourceidgale_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1880871
sourceformatXML
sourcesystemPC
galeidA185466796
sourcerecordidA185466796
originalsourceidFETCH-LOGICAL-1829t-b05a00218bd0e3620eb94ae7527fd583ab6a63f2c9f28734d4a608d5a8dfc07a0
addsrcrecordideNqN099r1EAQB_Agij2rT77LaVEQuTq72V95EY5DbaEoaMXHZbKZ3K0k2TQ_xP737nFHeydXKnkIbD77HbI7kyTPGZwySM37BoexIxCcqwfJhAmtZkIZ_TCZAHAzA5Oqo-RJ3_8CAMm0eJwcMcWlBAOT5GQ-XWFbheG6pWmN7TSU02FF09VYYzNdUhNqepo8KrHq6dn2fZz8-PTxcnE2u_j6-Xwxv5gxw7NhloPEWJGZvABKFQfKM4GkJddlIU2KuUKVltxlJTc6FYVABaaQaIrSgUY4Tj5sctsxr6lw1AwdVrbtfI3dtQ3o7f6Xxq_sMvy2zBgwmsWAs01AaKlB39He3qKhwYbCZorZPE21AYHCKZVpSSWYDEjHUyEy0un_jOJKWxS5ycucKSe0EOCQnJMxWOaqcKhljHqz_a0uXI3UD7b2vaOqwobC2Nt4V2mWgbgXcgM85Vl6L2RaSaVgXfpkA5dYkfVNGeK5uTW2c2akUEpnKqpXB5Rr_ZXdRacHUHwKqr0LDZU-ru-lvt3bEM1Af4Yljn1vz79_27fv7rbzy5-LLwe160Lfd1Te3A0Dux4JuzMSUb_Y7apbu52BCF5vAfYOq7LDxvn-1mnOJOPrlmD_lHV-wMGHdTP66o7iLzd7Nos3obvmL3jzKbQ
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid17656605
display
typearticle
titleA haplotype map of the human genome
creatorWillis, Td ; Yang, H. ; Hu, H. ; Yu, F. ; Wheeler, Da ; Leal, Sm ; Fulton, Ll ; Clarke, G. ; Mullikin, Jc ; Clayton, Ew ; Rogers, J. ; Kato, K. ; Niikawa, N. ; Wang, J. ; Jamieson, R. ; Hudson, Tj ; Barry, R. ; Camargo, A. ; Whittaker, P. ; Defelice, M. ; Frazer, Ka ; Daly, Mj ; Gupta, S. ; Nkwodimmah, C. ; Ajayi, I. ; Yakub, I. ; Cai, D. ; Lin, S. ; Kashuk, Cs ; Cutler, Dj ; Koboldt, Dc ; Miller, Rd ; Roy, J. ; Winchester, E. ; Bentley, Dr ; Sham, Pc ; Song, Yq ; Maller, J. ; He, Y. ; Chu, X. ; Smith, Av ; Krishnan, L. ; Stein, Ld ; Schaffner, Sf ; Fukushima, Y. ; Shen, Y. ; Ziaugra, L. ; Yao, Z. ; Purcell, S. ; Pe Er, I. ; Dermitzakis, Et ; Mccarroll, S. ; Deloukas, P. ; Macer, Dr ; Huang, W. ; Suda, E. ; Nagashima, A. ; Nazareth, L. ; Carter, Np ; Weir, Bs ; Morris, Ap ; Donnelly, P. ; Clee, Cm ; Griffiths, M. ; Pan, H. ; Sherry, St ; Hunt, S. ; Myers, S. ; Godbout, M. ; L Archevêque, P. ; Wang, Y. ; Zhang, Q. ; Sun, W. ; Li, Q. ; Wang, R. ; Xu, L. ; Tsui, Skw ; Xue, H. ; Barrett, J. ; Yu, J. ; Holden, Al ; Feolo, M. ; Murray, Ss ; Wang, Vo ; Chee, Ms ; Peterson, Jl ; Ferretti, V. ; Leboeuf, M. ; Shi, M. ; Spiegel, J. ; Phillips, Ms ; Sung, Lm ; Stranger, Be ; Weinstock, Gm ; Zacharia, Lf ; Mcvean, G. ; Thomas, Dj ; Fry, B. ; Roumy, S. ; Kennedy, K.
creatorcontribWillis, Td ; Yang, H. ; Hu, H. ; Yu, F. ; Wheeler, Da ; Leal, Sm ; Fulton, Ll ; Clarke, G. ; Mullikin, Jc ; Clayton, Ew ; Rogers, J. ; Kato, K. ; Niikawa, N. ; Wang, J. ; Jamieson, R. ; Hudson, Tj ; Barry, R. ; Camargo, A. ; Whittaker, P. ; Defelice, M. ; Frazer, Ka ; Daly, Mj ; Gupta, S. ; Nkwodimmah, C. ; Ajayi, I. ; Yakub, I. ; Cai, D. ; Lin, S. ; Kashuk, Cs ; Cutler, Dj ; Koboldt, Dc ; Miller, Rd ; Roy, J. ; Winchester, E. ; Bentley, Dr ; Sham, Pc ; Song, Yq ; Maller, J. ; He, Y. ; Chu, X. ; Smith, Av ; Krishnan, L. ; Stein, Ld ; Schaffner, Sf ; Fukushima, Y. ; Shen, Y. ; Ziaugra, L. ; Yao, Z. ; Purcell, S. ; Pe Er, I. ; Dermitzakis, Et ; Mccarroll, S. ; Deloukas, P. ; Macer, Dr ; Huang, W. ; Suda, E. ; Nagashima, A. ; Nazareth, L. ; Carter, Np ; Weir, Bs ; Morris, Ap ; Donnelly, P. ; Clee, Cm ; Griffiths, M. ; Pan, H. ; Sherry, St ; Hunt, S. ; Myers, S. ; Godbout, M. ; L Archevêque, P. ; Wang, Y. ; Zhang, Q. ; Sun, W. ; Li, Q. ; Wang, R. ; Xu, L. ; Tsui, Skw ; Xue, H. ; Barrett, J. ; Yu, J. ; Holden, Al ; Feolo, M. ; Murray, Ss ; Wang, Vo ; Chee, Ms ; Peterson, Jl ; Ferretti, V. ; Leboeuf, M. ; Shi, M. ; Spiegel, J. ; Phillips, Ms ; Sung, Lm ; Stranger, Be ; Weinstock, Gm ; Zacharia, Lf ; Mcvean, G. ; Thomas, Dj ; Fry, B. ; Roumy, S. ; Kennedy, K. ; International HapMap Consortium ; The International HapMap Consortium
descriptionInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution.
identifier
0ISSN: 0028-0836
1EISSN: 1476-4687
2DOI: 10.1038/nature04226
3PMID: 16255080
4CODEN: NATUAS
languageeng
publisherLondon: Nature Publishing
subjectArticle ; Biological and medical sciences ; Chromosomes ; Chromosomes, Human, Y - genetics ; DNA, Mitochondrial - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Frequency - genetics ; genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genome ; Genome, Human ; Haplotypes ; Haplotypes - genetics ; Human ; Humans ; Linkage Disequilibrium - genetics ; Mitochondrial ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Recombination, Genetic - genetics ; Selection, Genetic ; Single Nucleotide
ispartofNature, 2005, Vol.437 (7063), p.1299-1320
rights
02006 INIST-CNRS
1COPYRIGHT 2005 Nature Publishing Group
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1829t-b05a00218bd0e3620eb94ae7527fd583ab6a63f2c9f28734d4a608d5a8dfc07a0
citesFETCH-LOGICAL-1829t-b05a00218bd0e3620eb94ae7527fd583ab6a63f2c9f28734d4a608d5a8dfc07a0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17215127$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16255080$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Willis, Td
1Yang, H.
2Hu, H.
3Yu, F.
4Wheeler, Da
5Leal, Sm
6Fulton, Ll
7Clarke, G.
8Mullikin, Jc
9Clayton, Ew
10Rogers, J.
11Kato, K.
12Niikawa, N.
13Wang, J.
14Jamieson, R.
15Hudson, Tj
16Barry, R.
17Camargo, A.
18Whittaker, P.
19Defelice, M.
20Frazer, Ka
21Daly, Mj
22Gupta, S.
23Nkwodimmah, C.
24Ajayi, I.
25Yakub, I.
26Cai, D.
27Lin, S.
28Kashuk, Cs
29Cutler, Dj
30Koboldt, Dc
31Miller, Rd
32Roy, J.
33Winchester, E.
34Bentley, Dr
35Sham, Pc
36Song, Yq
37Maller, J.
38He, Y.
39Chu, X.
40Smith, Av
41Krishnan, L.
42Stein, Ld
43Schaffner, Sf
44Fukushima, Y.
45Shen, Y.
46Ziaugra, L.
47Yao, Z.
48Purcell, S.
49Pe Er, I.
50Dermitzakis, Et
51Mccarroll, S.
52Deloukas, P.
53Macer, Dr
54Huang, W.
55Suda, E.
56Nagashima, A.
57Nazareth, L.
58Carter, Np
59Weir, Bs
60Morris, Ap
61Donnelly, P.
62Clee, Cm
63Griffiths, M.
64Pan, H.
65Sherry, St
66Hunt, S.
67Myers, S.
68Godbout, M.
69L Archevêque, P.
70Wang, Y.
71Zhang, Q.
72Sun, W.
73Li, Q.
74Wang, R.
75Xu, L.
76Tsui, Skw
77Xue, H.
78Barrett, J.
79Yu, J.
80Holden, Al
81Feolo, M.
82Murray, Ss
83Wang, Vo
84Chee, Ms
85Peterson, Jl
86Ferretti, V.
87Leboeuf, M.
88Shi, M.
89Spiegel, J.
90Phillips, Ms
91Sung, Lm
92Stranger, Be
93Weinstock, Gm
94Zacharia, Lf
95Mcvean, G.
96Thomas, Dj
97Fry, B.
98Roumy, S.
99Kennedy, K.
100International HapMap Consortium
101The International HapMap Consortium
title
0A haplotype map of the human genome
1Nature
addtitleNature
descriptionInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution.
subject
0Article
1Biological and medical sciences
2Chromosomes
3Chromosomes, Human, Y - genetics
4DNA, Mitochondrial - genetics
5Fundamental and applied biological sciences. Psychology
6Gene Frequency - genetics
7genetics
8Genetics of eukaryotes. Biological and molecular evolution
9Genome
10Genome, Human
11Haplotypes
12Haplotypes - genetics
13Human
14Humans
15Linkage Disequilibrium - genetics
16Mitochondrial
17Polymorphism
18Polymorphism, Single Nucleotide - genetics
19Recombination, Genetic - genetics
20Selection, Genetic
21Single Nucleotide
issn
00028-0836
11476-4687
fulltextfalse
rsrctypearticle
creationdate2005
recordtypearticle
recordideNqN099r1EAQB_Agij2rT77LaVEQuTq72V95EY5DbaEoaMXHZbKZ3K0k2TQ_xP737nFHeydXKnkIbD77HbI7kyTPGZwySM37BoexIxCcqwfJhAmtZkIZ_TCZAHAzA5Oqo-RJ3_8CAMm0eJwcMcWlBAOT5GQ-XWFbheG6pWmN7TSU02FF09VYYzNdUhNqepo8KrHq6dn2fZz8-PTxcnE2u_j6-Xwxv5gxw7NhloPEWJGZvABKFQfKM4GkJddlIU2KuUKVltxlJTc6FYVABaaQaIrSgUY4Tj5sctsxr6lw1AwdVrbtfI3dtQ3o7f6Xxq_sMvy2zBgwmsWAs01AaKlB39He3qKhwYbCZorZPE21AYHCKZVpSSWYDEjHUyEy0un_jOJKWxS5ycucKSe0EOCQnJMxWOaqcKhljHqz_a0uXI3UD7b2vaOqwobC2Nt4V2mWgbgXcgM85Vl6L2RaSaVgXfpkA5dYkfVNGeK5uTW2c2akUEpnKqpXB5Rr_ZXdRacHUHwKqr0LDZU-ru-lvt3bEM1Af4Yljn1vz79_27fv7rbzy5-LLwe160Lfd1Te3A0Dux4JuzMSUb_Y7apbu52BCF5vAfYOq7LDxvn-1mnOJOPrlmD_lHV-wMGHdTP66o7iLzd7Nos3obvmL3jzKbQ
startdate20051027
enddate20051027
creator
0Willis, Td
1Yang, H.
2Hu, H.
3Yu, F.
4Wheeler, Da
5Leal, Sm
6Fulton, Ll
7Clarke, G.
8Mullikin, Jc
9Clayton, Ew
10Rogers, J.
11Kato, K.
12Niikawa, N.
13Wang, J.
14Jamieson, R.
15Hudson, Tj
16Barry, R.
17Camargo, A.
18Whittaker, P.
19Defelice, M.
20Frazer, Ka
21Daly, Mj
22Gupta, S.
23Nkwodimmah, C.
24Ajayi, I.
25Yakub, I.
26Cai, D.
27Lin, S.
28Kashuk, Cs
29Cutler, Dj
30Koboldt, Dc
31Miller, Rd
32Roy, J.
33Winchester, E.
34Bentley, Dr
35Sham, Pc
36Song, Yq
37Maller, J.
38He, Y.
39Chu, X.
40Smith, Av
41Krishnan, L.
42Stein, Ld
43Schaffner, Sf
44Fukushima, Y.
45Shen, Y.
46Ziaugra, L.
47Yao, Z.
48Purcell, S.
49Pe Er, I.
50Dermitzakis, Et
51Mccarroll, S.
52Deloukas, P.
53Macer, Dr
54Huang, W.
55Suda, E.
56Nagashima, A.
57Nazareth, L.
58Carter, Np
59Weir, Bs
60Morris, Ap
61Donnelly, P.
62Clee, Cm
63Griffiths, M.
64Pan, H.
65Sherry, St
66Hunt, S.
67Myers, S.
68Godbout, M.
69L Archevêque, P.
70Wang, Y.
71Zhang, Q.
72Sun, W.
73Li, Q.
74Wang, R.
75Xu, L.
76Tsui, Skw
77Xue, H.
78Barrett, J.
79Yu, J.
80Holden, Al
81Feolo, M.
82Murray, Ss
83Wang, Vo
84Chee, Ms
85Peterson, Jl
86Ferretti, V.
87Leboeuf, M.
88Shi, M.
89Spiegel, J.
90Phillips, Ms
91Sung, Lm
92Stranger, Be
93Weinstock, Gm
94Zacharia, Lf
95Mcvean, G.
96Thomas, Dj
97Fry, B.
98Roumy, S.
99Kennedy, K.
general
0Nature Publishing
1Nature Publishing Group
2United Kingdom
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
98FD
10FR3
11P64
12RC3
137U5
14L7M
157X8
16BOBZL
17CLFQK
185PM
sort
creationdate20051027
titleA haplotype map of the human genome
authorWillis, Td ; Yang, H. ; Hu, H. ; Yu, F. ; Wheeler, Da ; Leal, Sm ; Fulton, Ll ; Clarke, G. ; Mullikin, Jc ; Clayton, Ew ; Rogers, J. ; Kato, K. ; Niikawa, N. ; Wang, J. ; Jamieson, R. ; Hudson, Tj ; Barry, R. ; Camargo, A. ; Whittaker, P. ; Defelice, M. ; Frazer, Ka ; Daly, Mj ; Gupta, S. ; Nkwodimmah, C. ; Ajayi, I. ; Yakub, I. ; Cai, D. ; Lin, S. ; Kashuk, Cs ; Cutler, Dj ; Koboldt, Dc ; Miller, Rd ; Roy, J. ; Winchester, E. ; Bentley, Dr ; Sham, Pc ; Song, Yq ; Maller, J. ; He, Y. ; Chu, X. ; Smith, Av ; Krishnan, L. ; Stein, Ld ; Schaffner, Sf ; Fukushima, Y. ; Shen, Y. ; Ziaugra, L. ; Yao, Z. ; Purcell, S. ; Pe Er, I. ; Dermitzakis, Et ; Mccarroll, S. ; Deloukas, P. ; Macer, Dr ; Huang, W. ; Suda, E. ; Nagashima, A. ; Nazareth, L. ; Carter, Np ; Weir, Bs ; Morris, Ap ; Donnelly, P. ; Clee, Cm ; Griffiths, M. ; Pan, H. ; Sherry, St ; Hunt, S. ; Myers, S. ; Godbout, M. ; L Archevêque, P. ; Wang, Y. ; Zhang, Q. ; Sun, W. ; Li, Q. ; Wang, R. ; Xu, L. ; Tsui, Skw ; Xue, H. ; Barrett, J. ; Yu, J. ; Holden, Al ; Feolo, M. ; Murray, Ss ; Wang, Vo ; Chee, Ms ; Peterson, Jl ; Ferretti, V. ; Leboeuf, M. ; Shi, M. ; Spiegel, J. ; Phillips, Ms ; Sung, Lm ; Stranger, Be ; Weinstock, Gm ; Zacharia, Lf ; Mcvean, G. ; Thomas, Dj ; Fry, B. ; Roumy, S. ; Kennedy, K.
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1829t-b05a00218bd0e3620eb94ae7527fd583ab6a63f2c9f28734d4a608d5a8dfc07a0
rsrctypearticles
prefilterarticles
languageeng
creationdate2005
topic
0Article
1Biological and medical sciences
2Chromosomes
3Chromosomes, Human, Y - genetics
4DNA, Mitochondrial - genetics
5Fundamental and applied biological sciences. Psychology
6Gene Frequency - genetics
7genetics
8Genetics of eukaryotes. Biological and molecular evolution
9Genome
10Genome, Human
11Haplotypes
12Haplotypes - genetics
13Human
14Humans
15Linkage Disequilibrium - genetics
16Mitochondrial
17Polymorphism
18Polymorphism, Single Nucleotide - genetics
19Recombination, Genetic - genetics
20Selection, Genetic
21Single Nucleotide
toplevelpeer_reviewed
creatorcontrib
0Willis, Td
1Yang, H.
2Hu, H.
3Yu, F.
4Wheeler, Da
5Leal, Sm
6Fulton, Ll
7Clarke, G.
8Mullikin, Jc
9Clayton, Ew
10Rogers, J.
11Kato, K.
12Niikawa, N.
13Wang, J.
14Jamieson, R.
15Hudson, Tj
16Barry, R.
17Camargo, A.
18Whittaker, P.
19Defelice, M.
20Frazer, Ka
21Daly, Mj
22Gupta, S.
23Nkwodimmah, C.
24Ajayi, I.
25Yakub, I.
26Cai, D.
27Lin, S.
28Kashuk, Cs
29Cutler, Dj
30Koboldt, Dc
31Miller, Rd
32Roy, J.
33Winchester, E.
34Bentley, Dr
35Sham, Pc
36Song, Yq
37Maller, J.
38He, Y.
39Chu, X.
40Smith, Av
41Krishnan, L.
42Stein, Ld
43Schaffner, Sf
44Fukushima, Y.
45Shen, Y.
46Ziaugra, L.
47Yao, Z.
48Purcell, S.
49Pe Er, I.
50Dermitzakis, Et
51Mccarroll, S.
52Deloukas, P.
53Macer, Dr
54Huang, W.
55Suda, E.
56Nagashima, A.
57Nazareth, L.
58Carter, Np
59Weir, Bs
60Morris, Ap
61Donnelly, P.
62Clee, Cm
63Griffiths, M.
64Pan, H.
65Sherry, St
66Hunt, S.
67Myers, S.
68Godbout, M.
69L Archevêque, P.
70Wang, Y.
71Zhang, Q.
72Sun, W.
73Li, Q.
74Wang, R.
75Xu, L.
76Tsui, Skw
77Xue, H.
78Barrett, J.
79Yu, J.
80Holden, Al
81Feolo, M.
82Murray, Ss
83Wang, Vo
84Chee, Ms
85Peterson, Jl
86Ferretti, V.
87Leboeuf, M.
88Shi, M.
89Spiegel, J.
90Phillips, Ms
91Sung, Lm
92Stranger, Be
93Weinstock, Gm
94Zacharia, Lf
95Mcvean, G.
96Thomas, Dj
97Fry, B.
98Roumy, S.
99Kennedy, K.
100International HapMap Consortium
101The International HapMap Consortium
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Technology Research Database
9Engineering Research Database
10Biotechnology and BioEngineering Abstracts
11Genetics Abstracts
12Solid State and Superconductivity Abstracts
13Advanced Technologies Database with Aerospace
14MEDLINE - Academic
15OpenAIRE (Open Access)
16OpenAIRE
17PubMed Central (Full Participant titles)
jtitleNature
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Willis, Td
1Yang, H.
2Hu, H.
3Yu, F.
4Wheeler, Da
5Leal, Sm
6Fulton, Ll
7Clarke, G.
8Mullikin, Jc
9Clayton, Ew
10Rogers, J.
11Kato, K.
12Niikawa, N.
13Wang, J.
14Jamieson, R.
15Hudson, Tj
16Barry, R.
17Camargo, A.
18Whittaker, P.
19Defelice, M.
20Frazer, Ka
21Daly, Mj
22Gupta, S.
23Nkwodimmah, C.
24Ajayi, I.
25Yakub, I.
26Cai, D.
27Lin, S.
28Kashuk, Cs
29Cutler, Dj
30Koboldt, Dc
31Miller, Rd
32Roy, J.
33Winchester, E.
34Bentley, Dr
35Sham, Pc
36Song, Yq
37Maller, J.
38He, Y.
39Chu, X.
40Smith, Av
41Krishnan, L.
42Stein, Ld
43Schaffner, Sf
44Fukushima, Y.
45Shen, Y.
46Ziaugra, L.
47Yao, Z.
48Purcell, S.
49Pe Er, I.
50Dermitzakis, Et
51Mccarroll, S.
52Deloukas, P.
53Macer, Dr
54Huang, W.
55Suda, E.
56Nagashima, A.
57Nazareth, L.
58Carter, Np
59Weir, Bs
60Morris, Ap
61Donnelly, P.
62Clee, Cm
63Griffiths, M.
64Pan, H.
65Sherry, St
66Hunt, S.
67Myers, S.
68Godbout, M.
69L Archevêque, P.
70Wang, Y.
71Zhang, Q.
72Sun, W.
73Li, Q.
74Wang, R.
75Xu, L.
76Tsui, Skw
77Xue, H.
78Barrett, J.
79Yu, J.
80Holden, Al
81Feolo, M.
82Murray, Ss
83Wang, Vo
84Chee, Ms
85Peterson, Jl
86Ferretti, V.
87Leboeuf, M.
88Shi, M.
89Spiegel, J.
90Phillips, Ms
91Sung, Lm
92Stranger, Be
93Weinstock, Gm
94Zacharia, Lf
95Mcvean, G.
96Thomas, Dj
97Fry, B.
98Roumy, S.
99Kennedy, K.
aucorp
0International HapMap Consortium
1The International HapMap Consortium
formatjournal
genrearticle
ristypeJOUR
atitleA haplotype map of the human genome
jtitleNature
addtitleNature
date2005-10-27
risdate2005
volume437
issue7063
spage1299
epage1320
pages1299-1320
issn0028-0836
eissn1476-4687
codenNATUAS
notesLists of participants and affiliations appear at the end of the paper.
abstractInherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution.
copLondon
pubNature Publishing
pmid16255080
doi10.1038/nature04226
tpages22
oafree_for_read