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Malnutrition as an enteric infectious disease with long-term effects on child development

Malnutrition is a major contributor to mortality and is increasingly recognized as a cause of potentially lifelong functional disability. Yet, a rate‐limiting step in achieving normal nutrition may be impaired absorptive function due to multiple repeated enteric infections. This is especially proble... Full description

Journal Title: Nutrition reviews 2008-09, Vol.66 (9), p.487-505
Main Author: Guerrant, Richard L
Other Authors: Oriá, Reinaldo B , Moore, Sean R , Oriá, Mônica OB , Lima, Aldo AM
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Malden, USA: Blackwell Publishing Inc
ID: ISSN: 0029-6643
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2562291
title: Malnutrition as an enteric infectious disease with long-term effects on child development
format: Article
creator:
  • Guerrant, Richard L
  • Oriá, Reinaldo B
  • Moore, Sean R
  • Oriá, Mônica OB
  • Lima, Aldo AM
subjects:
  • Animals
  • Arginine - administration & dosage
  • Article
  • Biological and medical sciences
  • Child development
  • Child Nutrition Disorders - complications
  • Child Nutrition Disorders - genetics
  • Child Nutrition Disorders - therapy
  • Child, Preschool
  • Cognition Disorders - etiology
  • Colorectal diseases
  • Complications and side effects
  • DALYs (disability adjusted life years)
  • Diarrhea
  • Diarrhea - complications
  • Diarrhea - microbiology
  • Diarrhea - parasitology
  • Female
  • Fluid Therapy
  • Gastrointestinal diseases
  • Glutamine - administration & dosage
  • Growth Disorders - etiology
  • Humans
  • Infant
  • Infection - complications
  • Infectious diseases
  • Intervention
  • Intestinal Diseases - complications
  • Intestinal Diseases - microbiology
  • Intestinal Diseases, Parasitic - complications
  • Lead
  • malabsorption
  • Malnutrition
  • Medical sciences
  • Metabolic diseases
  • Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
  • Randomized Controlled Trials as Topic
  • Risk factors
ispartof: Nutrition reviews, 2008-09, Vol.66 (9), p.487-505
description: Malnutrition is a major contributor to mortality and is increasingly recognized as a cause of potentially lifelong functional disability. Yet, a rate‐limiting step in achieving normal nutrition may be impaired absorptive function due to multiple repeated enteric infections. This is especially problematic in children whose diets are marginal. In malnourished individuals, the infections are even more devastating. This review documents the evidence that intestinal infections lead to malnutrition and that malnutrition worsens intestinal infections. The clinical data presented here derive largely from long‐term cohort studies that are supported by controlled animal studies. Also reviewed are the mechanisms by which enteric infections lead to undernutrition and by which malnutrition worsens enteric infections, with implications for potential novel interventions. Further intervention studies are needed to document the relevance of these mechanisms and, most importantly, to interrupt the vicious diarrhea‐malnutrition cycle so children may develop their full potential.
language: eng
source:
identifier: ISSN: 0029-6643
fulltext: no_fulltext
issn:
  • 0029-6643
  • 1753-4887
url: Link


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titleMalnutrition as an enteric infectious disease with long-term effects on child development
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descriptionMalnutrition is a major contributor to mortality and is increasingly recognized as a cause of potentially lifelong functional disability. Yet, a rate‐limiting step in achieving normal nutrition may be impaired absorptive function due to multiple repeated enteric infections. This is especially problematic in children whose diets are marginal. In malnourished individuals, the infections are even more devastating. This review documents the evidence that intestinal infections lead to malnutrition and that malnutrition worsens intestinal infections. The clinical data presented here derive largely from long‐term cohort studies that are supported by controlled animal studies. Also reviewed are the mechanisms by which enteric infections lead to undernutrition and by which malnutrition worsens enteric infections, with implications for potential novel interventions. Further intervention studies are needed to document the relevance of these mechanisms and, most importantly, to interrupt the vicious diarrhea‐malnutrition cycle so children may develop their full potential.
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languageeng
publisherMalden, USA: Blackwell Publishing Inc
subjectAnimals ; Arginine - administration & dosage ; Article ; Biological and medical sciences ; Child development ; Child Nutrition Disorders - complications ; Child Nutrition Disorders - genetics ; Child Nutrition Disorders - therapy ; Child, Preschool ; Cognition Disorders - etiology ; Colorectal diseases ; Complications and side effects ; DALYs (disability adjusted life years) ; Diarrhea ; Diarrhea - complications ; Diarrhea - microbiology ; Diarrhea - parasitology ; Female ; Fluid Therapy ; Gastrointestinal diseases ; Glutamine - administration & dosage ; Growth Disorders - etiology ; Humans ; Infant ; Infection - complications ; Infectious diseases ; Intervention ; Intestinal Diseases - complications ; Intestinal Diseases - microbiology ; Intestinal Diseases, Parasitic - complications ; Lead ; malabsorption ; Malnutrition ; Medical sciences ; Metabolic diseases ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Randomized Controlled Trials as Topic ; Risk factors
ispartofNutrition reviews, 2008-09, Vol.66 (9), p.487-505
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descriptionMalnutrition is a major contributor to mortality and is increasingly recognized as a cause of potentially lifelong functional disability. Yet, a rate‐limiting step in achieving normal nutrition may be impaired absorptive function due to multiple repeated enteric infections. This is especially problematic in children whose diets are marginal. In malnourished individuals, the infections are even more devastating. This review documents the evidence that intestinal infections lead to malnutrition and that malnutrition worsens intestinal infections. The clinical data presented here derive largely from long‐term cohort studies that are supported by controlled animal studies. Also reviewed are the mechanisms by which enteric infections lead to undernutrition and by which malnutrition worsens enteric infections, with implications for potential novel interventions. Further intervention studies are needed to document the relevance of these mechanisms and, most importantly, to interrupt the vicious diarrhea‐malnutrition cycle so children may develop their full potential.
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0Animals
1Arginine - administration & dosage
2Article
3Biological and medical sciences
4Child development
5Child Nutrition Disorders - complications
6Child Nutrition Disorders - genetics
7Child Nutrition Disorders - therapy
8Child, Preschool
9Cognition Disorders - etiology
10Colorectal diseases
11Complications and side effects
12DALYs (disability adjusted life years)
13Diarrhea
14Diarrhea - complications
15Diarrhea - microbiology
16Diarrhea - parasitology
17Female
18Fluid Therapy
19Gastrointestinal diseases
20Glutamine - administration & dosage
21Growth Disorders - etiology
22Humans
23Infant
24Infection - complications
25Infectious diseases
26Intervention
27Intestinal Diseases - complications
28Intestinal Diseases - microbiology
29Intestinal Diseases, Parasitic - complications
30Lead
31malabsorption
32Malnutrition
33Medical sciences
34Metabolic diseases
35Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
36Randomized Controlled Trials as Topic
37Risk factors
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authorGuerrant, Richard L ; Oriá, Reinaldo B ; Moore, Sean R ; Oriá, Mônica OB ; Lima, Aldo AM
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1Arginine - administration & dosage
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4Child development
5Child Nutrition Disorders - complications
6Child Nutrition Disorders - genetics
7Child Nutrition Disorders - therapy
8Child, Preschool
9Cognition Disorders - etiology
10Colorectal diseases
11Complications and side effects
12DALYs (disability adjusted life years)
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14Diarrhea - complications
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18Fluid Therapy
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20Glutamine - administration & dosage
21Growth Disorders - etiology
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26Intervention
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28Intestinal Diseases - microbiology
29Intestinal Diseases, Parasitic - complications
30Lead
31malabsorption
32Malnutrition
33Medical sciences
34Metabolic diseases
35Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
36Randomized Controlled Trials as Topic
37Risk factors
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abstractMalnutrition is a major contributor to mortality and is increasingly recognized as a cause of potentially lifelong functional disability. Yet, a rate‐limiting step in achieving normal nutrition may be impaired absorptive function due to multiple repeated enteric infections. This is especially problematic in children whose diets are marginal. In malnourished individuals, the infections are even more devastating. This review documents the evidence that intestinal infections lead to malnutrition and that malnutrition worsens intestinal infections. The clinical data presented here derive largely from long‐term cohort studies that are supported by controlled animal studies. Also reviewed are the mechanisms by which enteric infections lead to undernutrition and by which malnutrition worsens enteric infections, with implications for potential novel interventions. Further intervention studies are needed to document the relevance of these mechanisms and, most importantly, to interrupt the vicious diarrhea‐malnutrition cycle so children may develop their full potential.
copMalden, USA
pubBlackwell Publishing Inc
pmid18752473
doi10.1111/j.1753-4887.2008.00082.x
tpages19
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