schliessen

Filtern

 

Bibliotheken

Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition

Context/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP). Design: We assayed AMH, inhibin B, and FSH in 300 archival folli... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2008-09, Vol.93 (9), p.3478-3483
Main Author: Sowers, MaryFran R
Other Authors: Eyvazzadeh, Aimee D , McConnell, Daniel , Yosef, Matheos , Jannausch, Mary L , Zhang, Daowen , Harlow, Sioban , Randolph, John F
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2567855
title: Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
format: Article
creator:
  • Sowers, MaryFran R
  • Eyvazzadeh, Aimee D
  • McConnell, Daniel
  • Yosef, Matheos
  • Jannausch, Mary L
  • Zhang, Daowen
  • Harlow, Sioban
  • Randolph, John F
subjects:
  • Abridged Index Medicus
  • Adult
  • Aging - blood
  • Aging - physiology
  • Anti-Mullerian Hormone - blood
  • Anti-Mullerian Hormone - physiology
  • Biological and medical sciences
  • Biomarkers - blood
  • Cohort Studies
  • endocrine system
  • endocrine system diseases
  • Endocrinopathies
  • Feeding. Feeding behavior
  • Female
  • Follicle Stimulating Hormone - blood
  • Forecasting
  • Fundamental and applied biological sciences. Psychology
  • genetic structures
  • hormone antagonists
  • hormone substitutes
  • hormones
  • Humans
  • Inhibins - blood
  • Inhibins - physiology
  • Medical sciences
  • Menopause - blood
  • Menopause - physiology
  • Menstruation - blood
  • Middle Aged
  • Models, Biological
  • Original
  • Original Article
  • Ovary - physiology
  • reproductive
  • urinary physiology
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vertebrates: endocrinology
ispartof: The journal of clinical endocrinology and metabolism, 2008-09, Vol.93 (9), p.3478-3483
description: Context/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP). Design: We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre- and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes. Results: Based on annual values from six time points prior to the FMP, logAMH longitudinal profiles declined and were highly associated with a time point 5 yr prior to FMP [including both observed and values below detection (P < 0.0001 and P = 0.0001, respectively)]. Baseline AMH profiles were also associated with age at FMP (P = 0.035). Models of declining loginhibin B profiles (including both observed and values below detection) were associated with time to FMP (P < 0.0001 and P = 0.0003, respectively). There was no significant association of loginhibin B profiles with age at FMP. Conclusions: AMH, an endocrine marker that reflects the transition of resting primordial follicles to growing follicles, declined to a time point 5 yr prior to the FMP; this may represent a critical biological juncture in the menopause transition. Low and nondetectable levels inhibin B levels also were observed 4–5 yr prior to the FMP but were less predictive of time to FMP or age at FMP.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6705847
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2567855
sourceformatXML
sourcesystemPC
sourcerecordid69521558
originalsourceidFETCH-LOGICAL-1531t-c2d129ba077e18ce07029dafc7ae5db5fab082082ace53e4c261fa3e69c81d980
addsrcrecordideNp1kc1v1DAQxSMEoqVw44xygRMpthPH9gVpWz62UqteisTNmtiTXa-y9mInlfjvcXZXhSKQLPswv_dmPK8oXlNyThklHzbmnBEiK8Jb8aQ4parhlaBKPC1OCWG0UoJ9PylepLQhhDYNr58XJ1RyVYtWnBZ24UdX3UzDgNGBL5chboPHErwtr_zadc6XF2W-xjWWn7B33o0u-DL05e097CWLlfOrvWBmbtCHHUwJy7sIPu3pl8WzHoaEr47vWfHty-e7y2V1ffv16nJxXVFe07EyzFKmOiBCIJUGiSBMWeiNAOS24z10RLJ8wCCvsTGspT3U2CojqVWSnBUfD767qduiNejHCIPeRbeF-FMHcPpxxbu1XoV7zfLuJOfZYHkwCDv04CI-0lqPow5Ws1boBoRpUUjVWWZZ3aBUouEtJb2RvW1Itnp3nCWGHxOmUW9dMjgM4DFMSbeKM8r5PPT7A2hiSCli_9CTEj0nrDdGzwnrOeGMv_nzj7_hY6QZeHsEIBkY-pyCcemBY6RlUtA2c-yvvsaNMMeVV-OG_3WvDyL0NpjoPO4ipqQ3YYo-R_tv1S8HtNBQ
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid69521558
display
typearticle
titleAnti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
creatorSowers, MaryFran R ; Eyvazzadeh, Aimee D ; McConnell, Daniel ; Yosef, Matheos ; Jannausch, Mary L ; Zhang, Daowen ; Harlow, Sioban ; Randolph, John F
creatorcontribSowers, MaryFran R ; Eyvazzadeh, Aimee D ; McConnell, Daniel ; Yosef, Matheos ; Jannausch, Mary L ; Zhang, Daowen ; Harlow, Sioban ; Randolph, John F
descriptionContext/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP). Design: We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre- and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes. Results: Based on annual values from six time points prior to the FMP, logAMH longitudinal profiles declined and were highly associated with a time point 5 yr prior to FMP [including both observed and values below detection (P < 0.0001 and P = 0.0001, respectively)]. Baseline AMH profiles were also associated with age at FMP (P = 0.035). Models of declining loginhibin B profiles (including both observed and values below detection) were associated with time to FMP (P < 0.0001 and P = 0.0003, respectively). There was no significant association of loginhibin B profiles with age at FMP. Conclusions: AMH, an endocrine marker that reflects the transition of resting primordial follicles to growing follicles, declined to a time point 5 yr prior to the FMP; this may represent a critical biological juncture in the menopause transition. Low and nondetectable levels inhibin B levels also were observed 4–5 yr prior to the FMP but were less predictive of time to FMP or age at FMP.
identifier
0ISSN: 0021-972X
1EISSN: 1945-7197
2DOI: 10.1210/jc.2008-0567
3PMID: 18593767
4CODEN: JCEMAZ
languageeng
publisherBethesda, MD: Endocrine Society
subjectAbridged Index Medicus ; Adult ; Aging - blood ; Aging - physiology ; Anti-Mullerian Hormone - blood ; Anti-Mullerian Hormone - physiology ; Biological and medical sciences ; Biomarkers - blood ; Cohort Studies ; endocrine system ; endocrine system diseases ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Follicle Stimulating Hormone - blood ; Forecasting ; Fundamental and applied biological sciences. Psychology ; genetic structures ; hormone antagonists ; hormone substitutes ; hormones ; Humans ; Inhibins - blood ; Inhibins - physiology ; Medical sciences ; Menopause - blood ; Menopause - physiology ; Menstruation - blood ; Middle Aged ; Models, Biological ; Original ; Original Article ; Ovary - physiology ; reproductive ; urinary physiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology
ispartofThe journal of clinical endocrinology and metabolism, 2008-09, Vol.93 (9), p.3478-3483
rights
02008 INIST-CNRS
1Copyright © 2008 by The Endocrine Society 2008
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1531t-c2d129ba077e18ce07029dafc7ae5db5fab082082ace53e4c261fa3e69c81d980
citesFETCH-LOGICAL-1531t-c2d129ba077e18ce07029dafc7ae5db5fab082082ace53e4c261fa3e69c81d980
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20628716$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18593767$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Sowers, MaryFran R
1Eyvazzadeh, Aimee D
2McConnell, Daniel
3Yosef, Matheos
4Jannausch, Mary L
5Zhang, Daowen
6Harlow, Sioban
7Randolph, John F
title
0Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
1The journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
descriptionContext/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP). Design: We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre- and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes. Results: Based on annual values from six time points prior to the FMP, logAMH longitudinal profiles declined and were highly associated with a time point 5 yr prior to FMP [including both observed and values below detection (P < 0.0001 and P = 0.0001, respectively)]. Baseline AMH profiles were also associated with age at FMP (P = 0.035). Models of declining loginhibin B profiles (including both observed and values below detection) were associated with time to FMP (P < 0.0001 and P = 0.0003, respectively). There was no significant association of loginhibin B profiles with age at FMP. Conclusions: AMH, an endocrine marker that reflects the transition of resting primordial follicles to growing follicles, declined to a time point 5 yr prior to the FMP; this may represent a critical biological juncture in the menopause transition. Low and nondetectable levels inhibin B levels also were observed 4–5 yr prior to the FMP but were less predictive of time to FMP or age at FMP.
subject
0Abridged Index Medicus
1Adult
2Aging - blood
3Aging - physiology
4Anti-Mullerian Hormone - blood
5Anti-Mullerian Hormone - physiology
6Biological and medical sciences
7Biomarkers - blood
8Cohort Studies
9endocrine system
10endocrine system diseases
11Endocrinopathies
12Feeding. Feeding behavior
13Female
14Follicle Stimulating Hormone - blood
15Forecasting
16Fundamental and applied biological sciences. Psychology
17genetic structures
18hormone antagonists
19hormone substitutes
20hormones
21Humans
22Inhibins - blood
23Inhibins - physiology
24Medical sciences
25Menopause - blood
26Menopause - physiology
27Menstruation - blood
28Middle Aged
29Models, Biological
30Original
31Original Article
32Ovary - physiology
33reproductive
34urinary physiology
35Vertebrates: anatomy and physiology, studies on body, several organs or systems
36Vertebrates: endocrinology
issn
00021-972X
11945-7197
fulltextfalse
rsrctypearticle
creationdate2008
recordtypearticle
recordideNp1kc1v1DAQxSMEoqVw44xygRMpthPH9gVpWz62UqteisTNmtiTXa-y9mInlfjvcXZXhSKQLPswv_dmPK8oXlNyThklHzbmnBEiK8Jb8aQ4parhlaBKPC1OCWG0UoJ9PylepLQhhDYNr58XJ1RyVYtWnBZ24UdX3UzDgNGBL5chboPHErwtr_zadc6XF2W-xjWWn7B33o0u-DL05e097CWLlfOrvWBmbtCHHUwJy7sIPu3pl8WzHoaEr47vWfHty-e7y2V1ffv16nJxXVFe07EyzFKmOiBCIJUGiSBMWeiNAOS24z10RLJ8wCCvsTGspT3U2CojqVWSnBUfD767qduiNejHCIPeRbeF-FMHcPpxxbu1XoV7zfLuJOfZYHkwCDv04CI-0lqPow5Ws1boBoRpUUjVWWZZ3aBUouEtJb2RvW1Itnp3nCWGHxOmUW9dMjgM4DFMSbeKM8r5PPT7A2hiSCli_9CTEj0nrDdGzwnrOeGMv_nzj7_hY6QZeHsEIBkY-pyCcemBY6RlUtA2c-yvvsaNMMeVV-OG_3WvDyL0NpjoPO4ipqQ3YYo-R_tv1S8HtNBQ
startdate200809
enddate200809
creator
0Sowers, MaryFran R
1Eyvazzadeh, Aimee D
2McConnell, Daniel
3Yosef, Matheos
4Jannausch, Mary L
5Zhang, Daowen
6Harlow, Sioban
7Randolph, John F
general
0Endocrine Society
1The Endocrine Society
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97X8
10BOBZL
11CLFQK
125PM
sort
creationdate200809
titleAnti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
authorSowers, MaryFran R ; Eyvazzadeh, Aimee D ; McConnell, Daniel ; Yosef, Matheos ; Jannausch, Mary L ; Zhang, Daowen ; Harlow, Sioban ; Randolph, John F
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1531t-c2d129ba077e18ce07029dafc7ae5db5fab082082ace53e4c261fa3e69c81d980
rsrctypearticles
prefilterarticles
languageeng
creationdate2008
topic
0Abridged Index Medicus
1Adult
2Aging - blood
3Aging - physiology
4Anti-Mullerian Hormone - blood
5Anti-Mullerian Hormone - physiology
6Biological and medical sciences
7Biomarkers - blood
8Cohort Studies
9endocrine system
10endocrine system diseases
11Endocrinopathies
12Feeding. Feeding behavior
13Female
14Follicle Stimulating Hormone - blood
15Forecasting
16Fundamental and applied biological sciences. Psychology
17genetic structures
18hormone antagonists
19hormone substitutes
20hormones
21Humans
22Inhibins - blood
23Inhibins - physiology
24Medical sciences
25Menopause - blood
26Menopause - physiology
27Menstruation - blood
28Middle Aged
29Models, Biological
30Original
31Original Article
32Ovary - physiology
33reproductive
34urinary physiology
35Vertebrates: anatomy and physiology, studies on body, several organs or systems
36Vertebrates: endocrinology
toplevelpeer_reviewed
creatorcontrib
0Sowers, MaryFran R
1Eyvazzadeh, Aimee D
2McConnell, Daniel
3Yosef, Matheos
4Jannausch, Mary L
5Zhang, Daowen
6Harlow, Sioban
7Randolph, John F
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8MEDLINE - Academic
9OpenAIRE (Open Access)
10OpenAIRE
11PubMed Central (Full Participant titles)
jtitleThe journal of clinical endocrinology and metabolism
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Sowers, MaryFran R
1Eyvazzadeh, Aimee D
2McConnell, Daniel
3Yosef, Matheos
4Jannausch, Mary L
5Zhang, Daowen
6Harlow, Sioban
7Randolph, John F
formatjournal
genrearticle
ristypeJOUR
atitleAnti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
jtitleThe journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
date2008-09
risdate2008
volume93
issue9
spage3478
epage3483
pages3478-3483
issn0021-972X
eissn1945-7197
codenJCEMAZ
notesAddress all correspondence and requests for reprints to: MaryFran Sowers, Ph.D., Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Room 1846, Ann Arbor, Michigan 48109. E-mail: mfsowers@umich.edu.
abstractContext/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP). Design: We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre- and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes. Results: Based on annual values from six time points prior to the FMP, logAMH longitudinal profiles declined and were highly associated with a time point 5 yr prior to FMP [including both observed and values below detection (P < 0.0001 and P = 0.0001, respectively)]. Baseline AMH profiles were also associated with age at FMP (P = 0.035). Models of declining loginhibin B profiles (including both observed and values below detection) were associated with time to FMP (P < 0.0001 and P = 0.0003, respectively). There was no significant association of loginhibin B profiles with age at FMP. Conclusions: AMH, an endocrine marker that reflects the transition of resting primordial follicles to growing follicles, declined to a time point 5 yr prior to the FMP; this may represent a critical biological juncture in the menopause transition. Low and nondetectable levels inhibin B levels also were observed 4–5 yr prior to the FMP but were less predictive of time to FMP or age at FMP.
copBethesda, MD
pubEndocrine Society
pmid18593767
doi10.1210/jc.2008-0567
oafree_for_read