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Impaired Medial Temporal Repetition Suppression is Related to Failure of Parietal Deactivation in Alzheimer Disease

Objectives Neural networks supporting encoding of new information are affected early in the course of Alzheimer disease (AD). Functional magnetic resonance imaging (fMRI) studies in AD have reported decreased medial temporal lobe (MTL) activation when comparing novel versus repeated stimuli. It is,... Full description

Journal Title: The American journal of geriatric psychiatry 2008, Vol.16 (4), p.283-292
Main Author: Pihlajamäki, Maija, M.D., Ph.D
Other Authors: DePeau, Kristina M., B.S , Blacker, Deborah, M.D., Sc.D , Sperling, Reisa A., M.D., M.M.Sc
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Inc
ID: ISSN: 1064-7481
Link: https://www.ncbi.nlm.nih.gov/pubmed/18378553
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2602949
title: Impaired Medial Temporal Repetition Suppression is Related to Failure of Parietal Deactivation in Alzheimer Disease
format: Article
creator:
  • Pihlajamäki, Maija, M.D., Ph.D
  • DePeau, Kristina M., B.S
  • Blacker, Deborah, M.D., Sc.D
  • Sperling, Reisa A., M.D., M.M.Sc
subjects:
  • Aged
  • Aged, 80 and over
  • Alzheimer disease
  • Alzheimer Disease - pathology
  • Article
  • Brain Mapping
  • Cognition - physiology
  • Educational Status
  • Female
  • fMRI
  • Hippocampus - pathology
  • Hippocampus - physiopathology
  • Humans
  • Internal Medicine
  • Magnetic Resonance Imaging
  • Male
  • medial temporal lobe
  • memory
  • parietal cortex
  • Parietal Lobe - pathology
  • Prosopagnosia - epidemiology
  • Reference Values
  • repetition suppression
  • Severity of Illness Index
  • Temporal Lobe - pathology
ispartof: The American journal of geriatric psychiatry, 2008, Vol.16 (4), p.283-292
description: Objectives Neural networks supporting encoding of new information are affected early in the course of Alzheimer disease (AD). Functional magnetic resonance imaging (fMRI) studies in AD have reported decreased medial temporal lobe (MTL) activation when comparing novel versus repeated stimuli. It is, however, unclear whether this finding is related to a failure of normal suppression of MTL activity to repeated stimuli in AD. Design, Setting, Participants and Measurements Twenty-nine healthy older subjects comprising a comparison group (OC) and 15 mild AD patients underwent fMRI during an associative memory paradigm in an academic medical center. The task consisted of blocks of Novel and Repeated face-name pairs and visual Fixation. To reveal neural correlates of processing repeatedly presented stimuli, Repeated blocks were contrasted to Fixation. Results AD patients demonstrated greater activation during Repeated stimuli in the MTL and in prefrontal and superior parietal cortices, compared with OC. In contrast, OC showed greater parietal task-induced deactivation than AD. Increased MTL activity during Repeated was correlated with more impaired parietal deactivation and poorer performance of the postscan recognition memory test of encoding the face-name pairs. Conclusion Reduction of MTL activity to repeated stimuli, which become highly familiarized to healthy OC, was impaired in AD. This abnormal increased MTL activation was related to disrupted parietal deactivation and to poor recognition memory performance. These preliminary results suggest that the typical episodic memory impairment seen in mild AD may manifest as a failure of normal repetition suppression and loss of “beneficial” deactivation in the MTL-parietal memory networks.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1064-7481
fulltext: fulltext
issn:
  • 1064-7481
  • 1545-7214
url: Link


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creatorPihlajamäki, Maija, M.D., Ph.D ; DePeau, Kristina M., B.S ; Blacker, Deborah, M.D., Sc.D ; Sperling, Reisa A., M.D., M.M.Sc
creatorcontribPihlajamäki, Maija, M.D., Ph.D ; DePeau, Kristina M., B.S ; Blacker, Deborah, M.D., Sc.D ; Sperling, Reisa A., M.D., M.M.Sc
descriptionObjectives Neural networks supporting encoding of new information are affected early in the course of Alzheimer disease (AD). Functional magnetic resonance imaging (fMRI) studies in AD have reported decreased medial temporal lobe (MTL) activation when comparing novel versus repeated stimuli. It is, however, unclear whether this finding is related to a failure of normal suppression of MTL activity to repeated stimuli in AD. Design, Setting, Participants and Measurements Twenty-nine healthy older subjects comprising a comparison group (OC) and 15 mild AD patients underwent fMRI during an associative memory paradigm in an academic medical center. The task consisted of blocks of Novel and Repeated face-name pairs and visual Fixation. To reveal neural correlates of processing repeatedly presented stimuli, Repeated blocks were contrasted to Fixation. Results AD patients demonstrated greater activation during Repeated stimuli in the MTL and in prefrontal and superior parietal cortices, compared with OC. In contrast, OC showed greater parietal task-induced deactivation than AD. Increased MTL activity during Repeated was correlated with more impaired parietal deactivation and poorer performance of the postscan recognition memory test of encoding the face-name pairs. Conclusion Reduction of MTL activity to repeated stimuli, which become highly familiarized to healthy OC, was impaired in AD. This abnormal increased MTL activation was related to disrupted parietal deactivation and to poor recognition memory performance. These preliminary results suggest that the typical episodic memory impairment seen in mild AD may manifest as a failure of normal repetition suppression and loss of “beneficial” deactivation in the MTL-parietal memory networks.
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subjectAged ; Aged, 80 and over ; Alzheimer disease ; Alzheimer Disease - pathology ; Article ; Brain Mapping ; Cognition - physiology ; Educational Status ; Female ; fMRI ; Hippocampus - pathology ; Hippocampus - physiopathology ; Humans ; Internal Medicine ; Magnetic Resonance Imaging ; Male ; medial temporal lobe ; memory ; parietal cortex ; Parietal Lobe - pathology ; Prosopagnosia - epidemiology ; Reference Values ; repetition suppression ; Severity of Illness Index ; Temporal Lobe - pathology
ispartofThe American journal of geriatric psychiatry, 2008, Vol.16 (4), p.283-292
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descriptionObjectives Neural networks supporting encoding of new information are affected early in the course of Alzheimer disease (AD). Functional magnetic resonance imaging (fMRI) studies in AD have reported decreased medial temporal lobe (MTL) activation when comparing novel versus repeated stimuli. It is, however, unclear whether this finding is related to a failure of normal suppression of MTL activity to repeated stimuli in AD. Design, Setting, Participants and Measurements Twenty-nine healthy older subjects comprising a comparison group (OC) and 15 mild AD patients underwent fMRI during an associative memory paradigm in an academic medical center. The task consisted of blocks of Novel and Repeated face-name pairs and visual Fixation. To reveal neural correlates of processing repeatedly presented stimuli, Repeated blocks were contrasted to Fixation. Results AD patients demonstrated greater activation during Repeated stimuli in the MTL and in prefrontal and superior parietal cortices, compared with OC. In contrast, OC showed greater parietal task-induced deactivation than AD. Increased MTL activity during Repeated was correlated with more impaired parietal deactivation and poorer performance of the postscan recognition memory test of encoding the face-name pairs. Conclusion Reduction of MTL activity to repeated stimuli, which become highly familiarized to healthy OC, was impaired in AD. This abnormal increased MTL activation was related to disrupted parietal deactivation and to poor recognition memory performance. These preliminary results suggest that the typical episodic memory impairment seen in mild AD may manifest as a failure of normal repetition suppression and loss of “beneficial” deactivation in the MTL-parietal memory networks.
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abstractObjectives Neural networks supporting encoding of new information are affected early in the course of Alzheimer disease (AD). Functional magnetic resonance imaging (fMRI) studies in AD have reported decreased medial temporal lobe (MTL) activation when comparing novel versus repeated stimuli. It is, however, unclear whether this finding is related to a failure of normal suppression of MTL activity to repeated stimuli in AD. Design, Setting, Participants and Measurements Twenty-nine healthy older subjects comprising a comparison group (OC) and 15 mild AD patients underwent fMRI during an associative memory paradigm in an academic medical center. The task consisted of blocks of Novel and Repeated face-name pairs and visual Fixation. To reveal neural correlates of processing repeatedly presented stimuli, Repeated blocks were contrasted to Fixation. Results AD patients demonstrated greater activation during Repeated stimuli in the MTL and in prefrontal and superior parietal cortices, compared with OC. In contrast, OC showed greater parietal task-induced deactivation than AD. Increased MTL activity during Repeated was correlated with more impaired parietal deactivation and poorer performance of the postscan recognition memory test of encoding the face-name pairs. Conclusion Reduction of MTL activity to repeated stimuli, which become highly familiarized to healthy OC, was impaired in AD. This abnormal increased MTL activation was related to disrupted parietal deactivation and to poor recognition memory performance. These preliminary results suggest that the typical episodic memory impairment seen in mild AD may manifest as a failure of normal repetition suppression and loss of “beneficial” deactivation in the MTL-parietal memory networks.
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