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The genome of the simian and human malaria parasite Plasmodium knowlesi

Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite spe... Full description

Journal Title: Nature (London) 2008-10-09, Vol.455 (7214), p.799-803
Main Author: Pain, A
Other Authors: Böhme, U , Berry, A. E , Mungall, K , Finn, R. D , Jackson, A. P , Mourier, T , Mistry, J , Pasini, E. M , Aslett, M. A , Balasubrammaniam, S , Borgwardt, K , Brooks, K , Carret, C , Carver, T. J , Cherevach, I , Chillingworth, T , Clark, T. G , Galinski, M. R , Hall, N , Harper, D , Harris, D , Hauser, H , Ivens, A , Janssen, C. S , Keane, T , Larke, N , Lapp, S , Marti, M , Moule, S , Meyer, I. M , Ormond, D , Peters, N , Sanders, M , Sanders, S , Sargeant, T. J , Simmonds, M , Smith, F , Squares, R , Thurston, S , Tivey, A. R , Walker, D , White, B , Zuiderwijk, E , Churcher, C , Quail, M. A , Cowman, A. F , Turner, C. M. R , Rajandream, M. A , Kocken, C. H. M , Thomas, A. W , Newbold, C. I , Barrell, B. G , Berriman, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: Nature Publishing
ID: ISSN: 0028-0836
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title: The genome of the simian and human malaria parasite Plasmodium knowlesi
format: Article
creator:
  • Pain, A
  • Böhme, U
  • Berry, A. E
  • Mungall, K
  • Finn, R. D
  • Jackson, A. P
  • Mourier, T
  • Mistry, J
  • Pasini, E. M
  • Aslett, M. A
  • Balasubrammaniam, S
  • Borgwardt, K
  • Brooks, K
  • Carret, C
  • Carver, T. J
  • Cherevach, I
  • Chillingworth, T
  • Clark, T. G
  • Galinski, M. R
  • Hall, N
  • Harper, D
  • Harris, D
  • Hauser, H
  • Ivens, A
  • Janssen, C. S
  • Keane, T
  • Larke, N
  • Lapp, S
  • Marti, M
  • Moule, S
  • Meyer, I. M
  • Ormond, D
  • Peters, N
  • Sanders, M
  • Sanders, S
  • Sargeant, T. J
  • Simmonds, M
  • Smith, F
  • Squares, R
  • Thurston, S
  • Tivey, A. R
  • Walker, D
  • White, B
  • Zuiderwijk, E
  • Churcher, C
  • Quail, M. A
  • Cowman, A. F
  • Turner, C. M. R
  • Rajandream, M. A
  • Kocken, C. H. M
  • Thomas, A. W
  • Newbold, C. I
  • Barrell, B. G
  • Berriman, M
subjects:
  • Amino Acid Sequence
  • Animals
  • Antigens, CD - chemistry
  • Antigens, CD - genetics
  • Article
  • Biological and medical sciences
  • Causes of
  • Chromosomes - genetics
  • Conserved Sequence
  • General aspects
  • Genes, Protozoan - genetics
  • Genetic aspects
  • Genome, Protozoan - genetics
  • Genomics
  • Health aspects
  • Human protozoal diseases
  • Humans
  • Infectious diseases
  • Macaca mulatta - parasitology
  • Malaria
  • Malaria - parasitology
  • Medical sciences
  • Molecular Sequence Data
  • Parasitic diseases
  • Plasmodium falciparum
  • Plasmodium knowlesi - classification
  • Plasmodium knowlesi - genetics
  • Plasmodium knowlesi - physiology
  • Protein Structure, Tertiary
  • Protozoal diseases
  • Protozoan Proteins - chemistry
  • Protozoan Proteins - genetics
  • Research
  • Sequence Analysis, DNA
  • Telomere - genetics
ispartof: Nature (London), 2008-10-09, Vol.455 (7214), p.799-803
description: Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated, and it has a close phylogenetic relationship to Plasmodium vivax, the second most important species of human malaria parasite (reviewed in ref. 4). Despite their relatedness, there are important phenotypic differences between them, such as host blood cell preference, absence of a dormant liver stage or 'hypnozoite' in P. knowlesi, and length of the asexual cycle (reviewed in ref. 4). Here we present an analysis of the P. knowlesi (H strain, Pk1(A+) clone) nuclear genome sequence. This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes. In contrast to other Plasmodium genomes, putative variant antigen families are dispersed throughout the genome and are associated with intrachromosomal telomere repeats. One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry.
language: eng
source:
identifier: ISSN: 0028-0836
fulltext: no_fulltext
issn:
  • 0028-0836
  • 1476-4687
url: Link


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titleThe genome of the simian and human malaria parasite Plasmodium knowlesi
creatorPain, A ; Böhme, U ; Berry, A. E ; Mungall, K ; Finn, R. D ; Jackson, A. P ; Mourier, T ; Mistry, J ; Pasini, E. M ; Aslett, M. A ; Balasubrammaniam, S ; Borgwardt, K ; Brooks, K ; Carret, C ; Carver, T. J ; Cherevach, I ; Chillingworth, T ; Clark, T. G ; Galinski, M. R ; Hall, N ; Harper, D ; Harris, D ; Hauser, H ; Ivens, A ; Janssen, C. S ; Keane, T ; Larke, N ; Lapp, S ; Marti, M ; Moule, S ; Meyer, I. M ; Ormond, D ; Peters, N ; Sanders, M ; Sanders, S ; Sargeant, T. J ; Simmonds, M ; Smith, F ; Squares, R ; Thurston, S ; Tivey, A. R ; Walker, D ; White, B ; Zuiderwijk, E ; Churcher, C ; Quail, M. A ; Cowman, A. F ; Turner, C. M. R ; Rajandream, M. A ; Kocken, C. H. M ; Thomas, A. W ; Newbold, C. I ; Barrell, B. G ; Berriman, M
creatorcontribPain, A ; Böhme, U ; Berry, A. E ; Mungall, K ; Finn, R. D ; Jackson, A. P ; Mourier, T ; Mistry, J ; Pasini, E. M ; Aslett, M. A ; Balasubrammaniam, S ; Borgwardt, K ; Brooks, K ; Carret, C ; Carver, T. J ; Cherevach, I ; Chillingworth, T ; Clark, T. G ; Galinski, M. R ; Hall, N ; Harper, D ; Harris, D ; Hauser, H ; Ivens, A ; Janssen, C. S ; Keane, T ; Larke, N ; Lapp, S ; Marti, M ; Moule, S ; Meyer, I. M ; Ormond, D ; Peters, N ; Sanders, M ; Sanders, S ; Sargeant, T. J ; Simmonds, M ; Smith, F ; Squares, R ; Thurston, S ; Tivey, A. R ; Walker, D ; White, B ; Zuiderwijk, E ; Churcher, C ; Quail, M. A ; Cowman, A. F ; Turner, C. M. R ; Rajandream, M. A ; Kocken, C. H. M ; Thomas, A. W ; Newbold, C. I ; Barrell, B. G ; Berriman, M
descriptionPlasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated, and it has a close phylogenetic relationship to Plasmodium vivax, the second most important species of human malaria parasite (reviewed in ref. 4). Despite their relatedness, there are important phenotypic differences between them, such as host blood cell preference, absence of a dormant liver stage or 'hypnozoite' in P. knowlesi, and length of the asexual cycle (reviewed in ref. 4). Here we present an analysis of the P. knowlesi (H strain, Pk1(A+) clone) nuclear genome sequence. This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes. In contrast to other Plasmodium genomes, putative variant antigen families are dispersed throughout the genome and are associated with intrachromosomal telomere repeats. One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry.
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languageeng
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subjectAmino Acid Sequence ; Animals ; Antigens, CD - chemistry ; Antigens, CD - genetics ; Article ; Biological and medical sciences ; Causes of ; Chromosomes - genetics ; Conserved Sequence ; General aspects ; Genes, Protozoan - genetics ; Genetic aspects ; Genome, Protozoan - genetics ; Genomics ; Health aspects ; Human protozoal diseases ; Humans ; Infectious diseases ; Macaca mulatta - parasitology ; Malaria ; Malaria - parasitology ; Medical sciences ; Molecular Sequence Data ; Parasitic diseases ; Plasmodium falciparum ; Plasmodium knowlesi - classification ; Plasmodium knowlesi - genetics ; Plasmodium knowlesi - physiology ; Protein Structure, Tertiary ; Protozoal diseases ; Protozoan Proteins - chemistry ; Protozoan Proteins - genetics ; Research ; Sequence Analysis, DNA ; Telomere - genetics
ispartofNature (London), 2008-10-09, Vol.455 (7214), p.799-803
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1Böhme, U
2Berry, A. E
3Mungall, K
4Finn, R. D
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6Mourier, T
7Mistry, J
8Pasini, E. M
9Aslett, M. A
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11Borgwardt, K
12Brooks, K
13Carret, C
14Carver, T. J
15Cherevach, I
16Chillingworth, T
17Clark, T. G
18Galinski, M. R
19Hall, N
20Harper, D
21Harris, D
22Hauser, H
23Ivens, A
24Janssen, C. S
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26Larke, N
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28Marti, M
29Moule, S
30Meyer, I. M
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33Sanders, M
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35Sargeant, T. J
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44Churcher, C
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48Rajandream, M. A
49Kocken, C. H. M
50Thomas, A. W
51Newbold, C. I
52Barrell, B. G
53Berriman, M
title
0The genome of the simian and human malaria parasite Plasmodium knowlesi
1Nature (London)
addtitleNature
descriptionPlasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated, and it has a close phylogenetic relationship to Plasmodium vivax, the second most important species of human malaria parasite (reviewed in ref. 4). Despite their relatedness, there are important phenotypic differences between them, such as host blood cell preference, absence of a dormant liver stage or 'hypnozoite' in P. knowlesi, and length of the asexual cycle (reviewed in ref. 4). Here we present an analysis of the P. knowlesi (H strain, Pk1(A+) clone) nuclear genome sequence. This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes. In contrast to other Plasmodium genomes, putative variant antigen families are dispersed throughout the genome and are associated with intrachromosomal telomere repeats. One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry.
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0Amino Acid Sequence
1Animals
2Antigens, CD - chemistry
3Antigens, CD - genetics
4Article
5Biological and medical sciences
6Causes of
7Chromosomes - genetics
8Conserved Sequence
9General aspects
10Genes, Protozoan - genetics
11Genetic aspects
12Genome, Protozoan - genetics
13Genomics
14Health aspects
15Human protozoal diseases
16Humans
17Infectious diseases
18Macaca mulatta - parasitology
19Malaria
20Malaria - parasitology
21Medical sciences
22Molecular Sequence Data
23Parasitic diseases
24Plasmodium falciparum
25Plasmodium knowlesi - classification
26Plasmodium knowlesi - genetics
27Plasmodium knowlesi - physiology
28Protein Structure, Tertiary
29Protozoal diseases
30Protozoan Proteins - chemistry
31Protozoan Proteins - genetics
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33Sequence Analysis, DNA
34Telomere - genetics
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1Böhme, U
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6Mourier, T
7Mistry, J
8Pasini, E. M
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10Balasubrammaniam, S
11Borgwardt, K
12Brooks, K
13Carret, C
14Carver, T. J
15Cherevach, I
16Chillingworth, T
17Clark, T. G
18Galinski, M. R
19Hall, N
20Harper, D
21Harris, D
22Hauser, H
23Ivens, A
24Janssen, C. S
25Keane, T
26Larke, N
27Lapp, S
28Marti, M
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30Meyer, I. M
31Ormond, D
32Peters, N
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titleThe genome of the simian and human malaria parasite Plasmodium knowlesi
authorPain, A ; Böhme, U ; Berry, A. E ; Mungall, K ; Finn, R. D ; Jackson, A. P ; Mourier, T ; Mistry, J ; Pasini, E. M ; Aslett, M. A ; Balasubrammaniam, S ; Borgwardt, K ; Brooks, K ; Carret, C ; Carver, T. J ; Cherevach, I ; Chillingworth, T ; Clark, T. G ; Galinski, M. R ; Hall, N ; Harper, D ; Harris, D ; Hauser, H ; Ivens, A ; Janssen, C. S ; Keane, T ; Larke, N ; Lapp, S ; Marti, M ; Moule, S ; Meyer, I. M ; Ormond, D ; Peters, N ; Sanders, M ; Sanders, S ; Sargeant, T. J ; Simmonds, M ; Smith, F ; Squares, R ; Thurston, S ; Tivey, A. R ; Walker, D ; White, B ; Zuiderwijk, E ; Churcher, C ; Quail, M. A ; Cowman, A. F ; Turner, C. M. R ; Rajandream, M. A ; Kocken, C. H. M ; Thomas, A. W ; Newbold, C. I ; Barrell, B. G ; Berriman, M
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0Amino Acid Sequence
1Animals
2Antigens, CD - chemistry
3Antigens, CD - genetics
4Article
5Biological and medical sciences
6Causes of
7Chromosomes - genetics
8Conserved Sequence
9General aspects
10Genes, Protozoan - genetics
11Genetic aspects
12Genome, Protozoan - genetics
13Genomics
14Health aspects
15Human protozoal diseases
16Humans
17Infectious diseases
18Macaca mulatta - parasitology
19Malaria
20Malaria - parasitology
21Medical sciences
22Molecular Sequence Data
23Parasitic diseases
24Plasmodium falciparum
25Plasmodium knowlesi - classification
26Plasmodium knowlesi - genetics
27Plasmodium knowlesi - physiology
28Protein Structure, Tertiary
29Protozoal diseases
30Protozoan Proteins - chemistry
31Protozoan Proteins - genetics
32Research
33Sequence Analysis, DNA
34Telomere - genetics
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10Balasubrammaniam, S
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1Böhme, U
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8Pasini, E. M
9Aslett, M. A
10Balasubrammaniam, S
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14Carver, T. J
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19Hall, N
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28Marti, M
29Moule, S
30Meyer, I. M
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34Sanders, S
35Sargeant, T. J
36Simmonds, M
37Smith, F
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39Thurston, S
40Tivey, A. R
41Walker, D
42White, B
43Zuiderwijk, E
44Churcher, C
45Quail, M. A
46Cowman, A. F
47Turner, C. M. R
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49Kocken, C. H. M
50Thomas, A. W
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notes
0These authors contributed equally to this work.
1Author Contributions B.G.B., C.I.N., N.H., A.W.T. and C.M.R.T. initiated the project. M.A.Q., T.C., H.H., S.M., D.O., S.S., N.L., F.S., K.Br., R.S., S.T., S.M., M.Sa., M.Si., B.W. and D.W. constructed DNA libraries and performed sequencing; B.W., M.S. and I.C. finished and assembled sequence data; K.M., D. Harris and C.Ch. managed finishing and sequencing teams; M.A.R. managed the computational and bioinformatics support team; M.A.A., S.B., T.J.C., D. Harper, T.K., A.R.T., E.Z. and N.P. provided computational and bioinformatic support; U.B., A.E.B., E.M.P., S.L. and B.G.B. annotated the genome data. U.B., A.E.B., I.M.M., C.Ca., C.I.N., R.D.F., J.M., T.M., C.M.R.T., T.G.C., K.Bo., M.R.G., C.S.J., T.J.S., M.M., A.F.C., A.P.J., C.H.M.K., M.B. and A.P. contributed specific analysis topics presented in this manuscript or contributed data to characterize the genome and commented on manuscript drafts. U.B. performed data submission in EMBL. A.P., M.B., A.E.B., U.B. and C.I.N. drafted and edited the paper. A.P. and M.B. directed the project and A.P. assembled the manuscript.
2Author Information The annotation and sequence data for the 14 chromosomes of the H strain of P. knowlesi have been submitted to the EMBL database with the following accession numbers: AM910983-AM910996. The annotation and sequence data are also available at http://www.genedb.org and http://www.plasmodb.org. Reprints and permissions information is available at www.nature.com/reprints. This paper is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence, and is freely available to all readers at www.nature.com/nature.
abstractPlasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated, and it has a close phylogenetic relationship to Plasmodium vivax, the second most important species of human malaria parasite (reviewed in ref. 4). Despite their relatedness, there are important phenotypic differences between them, such as host blood cell preference, absence of a dormant liver stage or 'hypnozoite' in P. knowlesi, and length of the asexual cycle (reviewed in ref. 4). Here we present an analysis of the P. knowlesi (H strain, Pk1(A+) clone) nuclear genome sequence. This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes. In contrast to other Plasmodium genomes, putative variant antigen families are dispersed throughout the genome and are associated with intrachromosomal telomere repeats. One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry.
copLondon
pubNature Publishing
pmid18843368
doi10.1038/nature07306
tpages6
oafree_for_read