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A systematic review of the association between circulating concentrations of C reactive protein and cancer

The objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified. 81 (90%) were prevalent case–control or cross-sectional studie... Full description

Journal Title: Journal of Epidemiology and Community Health 2007-09, Vol.61 (9), p.824-832
Main Author: Heikkilä, Katriina
Other Authors: Ebrahim, Shah , Lawlor, Debbie A
Format: Electronic Article Electronic Article
Language: English
Subjects:
CRP
IL
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd
ID: ISSN: 0143-005X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2703800
title: A systematic review of the association between circulating concentrations of C reactive protein and cancer
format: Article
creator:
  • Heikkilä, Katriina
  • Ebrahim, Shah
  • Lawlor, Debbie A
subjects:
  • Biological and medical sciences
  • Biomedical Research
  • C reactive protein
  • C-Reactive Protein - analysis
  • C-Reactive Protein - metabolism
  • Cancer
  • Colorectal cancer
  • CRP
  • Female
  • General aspects
  • Genes
  • Humans
  • IL
  • Inflammation
  • interleukin
  • Lung cancer
  • Male
  • Medical sciences
  • Miscellaneous
  • Multiple myeloma
  • Neoplasms - immunology
  • Physiological aspects
  • Proteins
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Review
  • Smoking
  • Studies
  • Systematic review
  • Tumors
  • United Kingdom
ispartof: Journal of Epidemiology and Community Health, 2007-09, Vol.61 (9), p.824-832
description: The objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified. 81 (90%) were prevalent case–control or cross-sectional studies, and only 9 studies had a prospective design. In most prevalent studies, CRP concentrations were found to be higher in patients with cancer than in healthy controls or controls with benign conditions. Of the nine large prospective studies identified in this review, four reported no relationship between circulating CRP levels and breast, prostate or colorectal cancers, and five studies found that CRP was associated with colorectal or lung cancers. Most of the studies evaluating CRP as a diagnostic marker of cancer did not present relevant statistical analyses. Furthermore, any association reported in the prevalent studies might reflect reverse causation, survival bias or confounding. The prospective studies provided no strong evidence for a causal role of CRP in cancer. Instead of further prevalent studies, more large prospective studies and CRP gene–cancer association studies would be valuable in investigating the role of CRP in cancer.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0143-005X
fulltext: fulltext
issn:
  • 0143-005X
  • 1470-2738
url: Link


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descriptionThe objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified. 81 (90%) were prevalent case–control or cross-sectional studies, and only 9 studies had a prospective design. In most prevalent studies, CRP concentrations were found to be higher in patients with cancer than in healthy controls or controls with benign conditions. Of the nine large prospective studies identified in this review, four reported no relationship between circulating CRP levels and breast, prostate or colorectal cancers, and five studies found that CRP was associated with colorectal or lung cancers. Most of the studies evaluating CRP as a diagnostic marker of cancer did not present relevant statistical analyses. Furthermore, any association reported in the prevalent studies might reflect reverse causation, survival bias or confounding. The prospective studies provided no strong evidence for a causal role of CRP in cancer. Instead of further prevalent studies, more large prospective studies and CRP gene–cancer association studies would be valuable in investigating the role of CRP in cancer.
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subjectBiological and medical sciences ; Biomedical Research ; C reactive protein ; C-Reactive Protein - analysis ; C-Reactive Protein - metabolism ; Cancer ; Colorectal cancer ; CRP ; Female ; General aspects ; Genes ; Humans ; IL ; Inflammation ; interleukin ; Lung cancer ; Male ; Medical sciences ; Miscellaneous ; Multiple myeloma ; Neoplasms - immunology ; Physiological aspects ; Proteins ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Review ; Smoking ; Studies ; Systematic review ; Tumors ; United Kingdom
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 MrsK Heikkilä
 Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK; k.heikkila@bristol.ac.uk
abstractThe objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified. 81 (90%) were prevalent case–control or cross-sectional studies, and only 9 studies had a prospective design. In most prevalent studies, CRP concentrations were found to be higher in patients with cancer than in healthy controls or controls with benign conditions. Of the nine large prospective studies identified in this review, four reported no relationship between circulating CRP levels and breast, prostate or colorectal cancers, and five studies found that CRP was associated with colorectal or lung cancers. Most of the studies evaluating CRP as a diagnostic marker of cancer did not present relevant statistical analyses. Furthermore, any association reported in the prevalent studies might reflect reverse causation, survival bias or confounding. The prospective studies provided no strong evidence for a causal role of CRP in cancer. Instead of further prevalent studies, more large prospective studies and CRP gene–cancer association studies would be valuable in investigating the role of CRP in cancer.
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