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Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda

Herpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections. : Six thousand three hundred ninety-six men were evaluated for serologic HSV-2 and HIV infections and behaviors during a male cir... Full description

Journal Title: AIDS (London) 2009, Vol.23 (12), p.1589-1594
Main Author: TOBIAN, Aaron A. R
Other Authors: SSEMPIJJA, Victor , QUINN, Thomas C , GRAY, Ronald H , KIGOZI, Godfrey , OLIVER, Amy E , SERWADDA, David , MAKUMBI, Frederick , NALUGODA, Frederick K , IGA, Boaz , REYNOLDS, Steven J , WAWER, Maria J
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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title: Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda
format: Article
creator:
  • TOBIAN, Aaron A. R
  • SSEMPIJJA, Victor
  • QUINN, Thomas C
  • GRAY, Ronald H
  • KIGOZI, Godfrey
  • OLIVER, Amy E
  • SERWADDA, David
  • MAKUMBI, Frederick
  • NALUGODA, Frederick K
  • IGA, Boaz
  • REYNOLDS, Steven J
  • WAWER, Maria J
subjects:
  • Adolescent
  • Adult
  • AIDS/HIV
  • Article
  • Biological and medical sciences
  • Chronic Disease
  • Circumcision, Male
  • Epidemiologic Methods
  • Herpes Genitalis - epidemiology
  • Herpes Genitalis - transmission
  • Herpes simplex virus 2
  • herpes simplex virus type 2
  • HIV
  • HIV Infections - epidemiology
  • HIV Infections - prevention & control
  • HIV Infections - transmission
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Infectious diseases
  • Male
  • male circumcision
  • Medical sciences
  • Middle Aged
  • risk factors
  • Uganda
  • Uganda - epidemiology
  • Unsafe Sex
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Young Adult
ispartof: AIDS (London), 2009, Vol.23 (12), p.1589-1594
description: Herpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections. : Six thousand three hundred ninety-six men were evaluated for serologic HSV-2 and HIV infections and behaviors during a male circumcision trial in Rakai, Uganda. HIV and HSV-2 status were determined using enzyme-linked immunosorbent assays and confirmed by HIV-1 and HSV-2 western blots. A Poisson multivariable model was used to estimate adjusted incidence rate ratios of HIV acquisition associated with HSV-2 and other covariates. HIV incidence was 1.09/100 person-years and acquisition was associated with incident HSV-2 infection [adjusted incidence rate ratio (adjIRR) 5.28, 95% confidence interval (CI) 2.79-9.98], chronic HSV-2 infection (adjIRR 2.78, 95% CI 1.64-5.68), genital ulcer disease, urethral discharge, genital washing after intercourse, being unmarried, and being uncircumcised. Sixteen men acquired both HIV and HSV-2 during the trial: four acquired HIV first, three acquired HSV-2 first, and nine acquired both infections in the same follow-up interval. The findings suggest that unsafe sex places men at risk of both HIV and HSV-2 infections, and it is unclear whether HSV-2 acquisition is a cofactor for HIV infection or a marker of correlated sexual exposures. This reinforces the need for promotion of safe sex as the primary method of prevention of both viruses.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleIncident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda
creatorTOBIAN, Aaron A. R ; SSEMPIJJA, Victor ; QUINN, Thomas C ; GRAY, Ronald H ; KIGOZI, Godfrey ; OLIVER, Amy E ; SERWADDA, David ; MAKUMBI, Frederick ; NALUGODA, Frederick K ; IGA, Boaz ; REYNOLDS, Steven J ; WAWER, Maria J
creatorcontribTOBIAN, Aaron A. R ; SSEMPIJJA, Victor ; QUINN, Thomas C ; GRAY, Ronald H ; KIGOZI, Godfrey ; OLIVER, Amy E ; SERWADDA, David ; MAKUMBI, Frederick ; NALUGODA, Frederick K ; IGA, Boaz ; REYNOLDS, Steven J ; WAWER, Maria J
descriptionHerpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections. : Six thousand three hundred ninety-six men were evaluated for serologic HSV-2 and HIV infections and behaviors during a male circumcision trial in Rakai, Uganda. HIV and HSV-2 status were determined using enzyme-linked immunosorbent assays and confirmed by HIV-1 and HSV-2 western blots. A Poisson multivariable model was used to estimate adjusted incidence rate ratios of HIV acquisition associated with HSV-2 and other covariates. HIV incidence was 1.09/100 person-years and acquisition was associated with incident HSV-2 infection [adjusted incidence rate ratio (adjIRR) 5.28, 95% confidence interval (CI) 2.79-9.98], chronic HSV-2 infection (adjIRR 2.78, 95% CI 1.64-5.68), genital ulcer disease, urethral discharge, genital washing after intercourse, being unmarried, and being uncircumcised. Sixteen men acquired both HIV and HSV-2 during the trial: four acquired HIV first, three acquired HSV-2 first, and nine acquired both infections in the same follow-up interval. The findings suggest that unsafe sex places men at risk of both HIV and HSV-2 infections, and it is unclear whether HSV-2 acquisition is a cofactor for HIV infection or a marker of correlated sexual exposures. This reinforces the need for promotion of safe sex as the primary method of prevention of both viruses.
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subjectAdolescent ; Adult ; AIDS/HIV ; Article ; Biological and medical sciences ; Chronic Disease ; Circumcision, Male ; Epidemiologic Methods ; Herpes Genitalis - epidemiology ; Herpes Genitalis - transmission ; Herpes simplex virus 2 ; herpes simplex virus type 2 ; HIV ; HIV Infections - epidemiology ; HIV Infections - prevention & control ; HIV Infections - transmission ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; male circumcision ; Medical sciences ; Middle Aged ; risk factors ; Uganda ; Uganda - epidemiology ; Unsafe Sex ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult
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descriptionHerpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections. : Six thousand three hundred ninety-six men were evaluated for serologic HSV-2 and HIV infections and behaviors during a male circumcision trial in Rakai, Uganda. HIV and HSV-2 status were determined using enzyme-linked immunosorbent assays and confirmed by HIV-1 and HSV-2 western blots. A Poisson multivariable model was used to estimate adjusted incidence rate ratios of HIV acquisition associated with HSV-2 and other covariates. HIV incidence was 1.09/100 person-years and acquisition was associated with incident HSV-2 infection [adjusted incidence rate ratio (adjIRR) 5.28, 95% confidence interval (CI) 2.79-9.98], chronic HSV-2 infection (adjIRR 2.78, 95% CI 1.64-5.68), genital ulcer disease, urethral discharge, genital washing after intercourse, being unmarried, and being uncircumcised. Sixteen men acquired both HIV and HSV-2 during the trial: four acquired HIV first, three acquired HSV-2 first, and nine acquired both infections in the same follow-up interval. The findings suggest that unsafe sex places men at risk of both HIV and HSV-2 infections, and it is unclear whether HSV-2 acquisition is a cofactor for HIV infection or a marker of correlated sexual exposures. This reinforces the need for promotion of safe sex as the primary method of prevention of both viruses.
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titleIncident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda
authorTOBIAN, Aaron A. R ; SSEMPIJJA, Victor ; QUINN, Thomas C ; GRAY, Ronald H ; KIGOZI, Godfrey ; OLIVER, Amy E ; SERWADDA, David ; MAKUMBI, Frederick ; NALUGODA, Frederick K ; IGA, Boaz ; REYNOLDS, Steven J ; WAWER, Maria J
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notesAuthor contributions: R.H. Gray, D. Serwadda, M.J. Wawer, G. Kigozi, and F. Makumbi designed and conducted the randomized trials that provided data for this analysis. A.A.R. Tobian, V. Ssempijja, D. Serwadda, S.J. Reynolds, M.J. Wawer, T.C. Quinn, and R.H. Gray designed the analysis. A.A.R. Tobian, V. Ssempijja, G. Kigozi, A.E. Oliver, F. Makumbi, F.K. Nalugoda, and B. Iga collected data or did experiments for the study. A.A.R. Tobian, V. Ssempijja, S.J. Reynolds, M.J. Wawer, T.C. Quinn, and R.H. Gray analyzed the data. V. Ssempijja, G. Kigozi, D. Serwadda, F. Makumbi, F.K. Nalugoda, and B. Iga enrolled study participants. A.A.R. Tobian, V. Ssempijja, G. Kigozi, A.E. Oliver, D. Serwadda, F. Makumbi, F.K. Nalugoda, B. Iga, O. Laeyendecker, M.Z. Chen, S.J. Reynolds, M.J. Wawer, T.C. Quinn, and R.H. Gray contributed to writing the paper.
abstractHerpes simplex virus type 2 (HSV-2) infection is associated with an increased risk for acquiring HIV, but little is known about the temporal sequence of these infections. : Six thousand three hundred ninety-six men were evaluated for serologic HSV-2 and HIV infections and behaviors during a male circumcision trial in Rakai, Uganda. HIV and HSV-2 status were determined using enzyme-linked immunosorbent assays and confirmed by HIV-1 and HSV-2 western blots. A Poisson multivariable model was used to estimate adjusted incidence rate ratios of HIV acquisition associated with HSV-2 and other covariates. HIV incidence was 1.09/100 person-years and acquisition was associated with incident HSV-2 infection [adjusted incidence rate ratio (adjIRR) 5.28, 95% confidence interval (CI) 2.79-9.98], chronic HSV-2 infection (adjIRR 2.78, 95% CI 1.64-5.68), genital ulcer disease, urethral discharge, genital washing after intercourse, being unmarried, and being uncircumcised. Sixteen men acquired both HIV and HSV-2 during the trial: four acquired HIV first, three acquired HSV-2 first, and nine acquired both infections in the same follow-up interval. The findings suggest that unsafe sex places men at risk of both HIV and HSV-2 infections, and it is unclear whether HSV-2 acquisition is a cofactor for HIV infection or a marker of correlated sexual exposures. This reinforces the need for promotion of safe sex as the primary method of prevention of both viruses.
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pubLippincott Williams & Wilkins
pmid19474649
doi10.1097/QAD.0b013e32832d4042
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