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Free choice activates a decision circuit between frontal and parietal cortex

We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but... Full description

Journal Title: Nature 2008, Vol.453 (7193), p.406-409
Main Author: Pesaran, Bijan
Other Authors: Nelson, Matthew J , Andersen, Richard A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: Nature Publishing
ID: ISSN: 0028-0836
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2728060
title: Free choice activates a decision circuit between frontal and parietal cortex
format: Article
creator:
  • Pesaran, Bijan
  • Nelson, Matthew J
  • Andersen, Richard A
subjects:
  • Action Potentials - physiology
  • Anatomical correlates of behavior
  • Animals
  • Article
  • Behavioral psychophysiology
  • Biological and medical sciences
  • Choice (Psychology)
  • Choice Behavior - physiology
  • Electrophysiology
  • Fixation, Ocular - physiology
  • Frontal Lobe - physiology
  • Frontal lobes
  • Fundamental and applied biological sciences. Psychology
  • Macaca mulatta - physiology
  • Male
  • Neural Pathways - physiology
  • Neurons - metabolism
  • Parietal Lobe - physiology
  • Parietal lobes
  • Photic Stimulation
  • Physiological aspects
  • Probability
  • Psychology. Psychoanalysis. Psychiatry
  • Psychology. Psychophysiology
  • Reward
  • ROC Curve
  • Saccades - physiology
ispartof: Nature, 2008, Vol.453 (7193), p.406-409
description: We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.
language: eng
source:
identifier: ISSN: 0028-0836
fulltext: no_fulltext
issn:
  • 0028-0836
  • 1476-4687
  • 1476-4679
url: Link


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descriptionWe often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.
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subjectAction Potentials - physiology ; Anatomical correlates of behavior ; Animals ; Article ; Behavioral psychophysiology ; Biological and medical sciences ; Choice (Psychology) ; Choice Behavior - physiology ; Electrophysiology ; Fixation, Ocular - physiology ; Frontal Lobe - physiology ; Frontal lobes ; Fundamental and applied biological sciences. Psychology ; Macaca mulatta - physiology ; Male ; Neural Pathways - physiology ; Neurons - metabolism ; Parietal Lobe - physiology ; Parietal lobes ; Photic Stimulation ; Physiological aspects ; Probability ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Reward ; ROC Curve ; Saccades - physiology
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abstractWe often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex that are anatomically connected into long-range circuits. These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.
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