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Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials

To evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk. Combined analysis of data from African trials of men who were randomized to and underwent circumcision. We examined two associations: early sex (intercourse

Journal Title: AIDS (London) 2009, Vol.23 (12), p.1557-1564
Main Author: MEHTA, Supriya D
Other Authors: GRAY, Ronald H , WAWER, Maria J , BAILEY, Robert C , AUVERT, Bertran , MOSES, Stephen , KIGOZI, Godfrey , TALJAARD, Dirk , PUREN, Adrien , AGOT, Kawango , SERWADDA, David , PARKER, Corette B
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2772053
title: Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials
format: Article
creator:
  • MEHTA, Supriya D
  • GRAY, Ronald H
  • WAWER, Maria J
  • BAILEY, Robert C
  • AUVERT, Bertran
  • MOSES, Stephen
  • KIGOZI, Godfrey
  • TALJAARD, Dirk
  • PUREN, Adrien
  • AGOT, Kawango
  • SERWADDA, David
  • PARKER, Corette B
subjects:
  • Adolescent
  • Africa
  • AIDS/HIV
  • Article
  • Biological and medical sciences
  • Circumcision, Male - adverse effects
  • Coitus
  • Follow-Up Studies
  • HIV Infections - prevention & control
  • HIV risk
  • HIV Seropositivity - transmission
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Infectious diseases
  • Male
  • male circumcision
  • Medical sciences
  • Postoperative Period
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • seroconversion
  • Sexual Behavior
  • sexual intercourse
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Wound Healing
  • Young Adult
ispartof: AIDS (London), 2009, Vol.23 (12), p.1557-1564
description: To evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk. Combined analysis of data from African trials of men who were randomized to and underwent circumcision. We examined two associations: early sex (intercourse
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleDoes sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials
creatorMEHTA, Supriya D ; GRAY, Ronald H ; WAWER, Maria J ; BAILEY, Robert C ; AUVERT, Bertran ; MOSES, Stephen ; KIGOZI, Godfrey ; TALJAARD, Dirk ; PUREN, Adrien ; AGOT, Kawango ; SERWADDA, David ; PARKER, Corette B
creatorcontribMEHTA, Supriya D ; GRAY, Ronald H ; WAWER, Maria J ; BAILEY, Robert C ; AUVERT, Bertran ; MOSES, Stephen ; KIGOZI, Godfrey ; TALJAARD, Dirk ; PUREN, Adrien ; AGOT, Kawango ; SERWADDA, David ; PARKER, Corette B
descriptionTo evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk. Combined analysis of data from African trials of men who were randomized to and underwent circumcision. We examined two associations: early sex (intercourse <42 days after circumcision) and HIV acquisition at 3 months for the Orange Farm and Kisumu trials and at 6 months for the Rakai and Kisumu trials and incomplete wound healing at 1 month and seroconversion at 3 and 6 months for the Kisumu trial and at 6 months for the Rakai trial. Early sex was reported by 3.9% of participants in Kisumu, 5.4% in Rakai, and 22.5% in Orange Farm. HIV seroprevalence was 0.0% at 3 months and 1.9% at 6 months among 18-24-year-olds reporting early sex and 0.2% at 3 months and 0.6% at 6 months among those who did not report early sex. In pooled analyses, men reporting early sex did not have higher HIV infection risk at 3 or 6 months. In Kisumu, 16 (1.3%) men had incomplete wound healing at the 30-day visit. One (6.3%) of these seroconverted at 3 months compared with 2 (0.2%) of 1246 men with complete wound healing (P = 0.075). No association was observed between incomplete wound healing and seroconversion for Rakai participants. Most men delayed intercourse after circumcision. Early sex after circumcision was not associated with HIV risk, although the study power was limited. Nevertheless, men should delay intercourse to limit the potential for increased HIV risk until complete wound healing.
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subjectAdolescent ; Africa ; AIDS/HIV ; Article ; Biological and medical sciences ; Circumcision, Male - adverse effects ; Coitus ; Follow-Up Studies ; HIV Infections - prevention & control ; HIV risk ; HIV Seropositivity - transmission ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; male circumcision ; Medical sciences ; Postoperative Period ; Randomized Controlled Trials as Topic ; Risk Assessment ; seroconversion ; Sexual Behavior ; sexual intercourse ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Wound Healing ; Young Adult
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descriptionTo evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk. Combined analysis of data from African trials of men who were randomized to and underwent circumcision. We examined two associations: early sex (intercourse <42 days after circumcision) and HIV acquisition at 3 months for the Orange Farm and Kisumu trials and at 6 months for the Rakai and Kisumu trials and incomplete wound healing at 1 month and seroconversion at 3 and 6 months for the Kisumu trial and at 6 months for the Rakai trial. Early sex was reported by 3.9% of participants in Kisumu, 5.4% in Rakai, and 22.5% in Orange Farm. HIV seroprevalence was 0.0% at 3 months and 1.9% at 6 months among 18-24-year-olds reporting early sex and 0.2% at 3 months and 0.6% at 6 months among those who did not report early sex. In pooled analyses, men reporting early sex did not have higher HIV infection risk at 3 or 6 months. In Kisumu, 16 (1.3%) men had incomplete wound healing at the 30-day visit. One (6.3%) of these seroconverted at 3 months compared with 2 (0.2%) of 1246 men with complete wound healing (P = 0.075). No association was observed between incomplete wound healing and seroconversion for Rakai participants. Most men delayed intercourse after circumcision. Early sex after circumcision was not associated with HIV risk, although the study power was limited. Nevertheless, men should delay intercourse to limit the potential for increased HIV risk until complete wound healing.
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8HIV Infections - prevention & control
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titleDoes sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials
authorMEHTA, Supriya D ; GRAY, Ronald H ; WAWER, Maria J ; BAILEY, Robert C ; AUVERT, Bertran ; MOSES, Stephen ; KIGOZI, Godfrey ; TALJAARD, Dirk ; PUREN, Adrien ; AGOT, Kawango ; SERWADDA, David ; PARKER, Corette B
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atitleDoes sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials
jtitleAIDS (London)
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issue12
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pages1557-1564
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abstractTo evaluate whether sexual intercourse soon after adult male circumcision affected HIV risk. Combined analysis of data from African trials of men who were randomized to and underwent circumcision. We examined two associations: early sex (intercourse <42 days after circumcision) and HIV acquisition at 3 months for the Orange Farm and Kisumu trials and at 6 months for the Rakai and Kisumu trials and incomplete wound healing at 1 month and seroconversion at 3 and 6 months for the Kisumu trial and at 6 months for the Rakai trial. Early sex was reported by 3.9% of participants in Kisumu, 5.4% in Rakai, and 22.5% in Orange Farm. HIV seroprevalence was 0.0% at 3 months and 1.9% at 6 months among 18-24-year-olds reporting early sex and 0.2% at 3 months and 0.6% at 6 months among those who did not report early sex. In pooled analyses, men reporting early sex did not have higher HIV infection risk at 3 or 6 months. In Kisumu, 16 (1.3%) men had incomplete wound healing at the 30-day visit. One (6.3%) of these seroconverted at 3 months compared with 2 (0.2%) of 1246 men with complete wound healing (P = 0.075). No association was observed between incomplete wound healing and seroconversion for Rakai participants. Most men delayed intercourse after circumcision. Early sex after circumcision was not associated with HIV risk, although the study power was limited. Nevertheless, men should delay intercourse to limit the potential for increased HIV risk until complete wound healing.
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pmid19571722
doi10.1097/QAD.0b013e32832afe95
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