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Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging

HIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (M... Full description

Journal Title: AIDS (London) 2009, Vol.23 (8), p.941-949
Main Author: FLORIS-MOORE, Michelle
Other Authors: FAYAD, Zahi A , SCHECTER, Alison D , BERMAN, Joan W , MANI, Venkatesh , SCHOENBAUM, Ellie E , KLEIN, Robert S , WEINSHELBAUM, Karen B , FUSTER, Valentin , HOWARD, Andrea A , YUNGTAI LO
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2786203
title: Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging
format: Article
creator:
  • FLORIS-MOORE, Michelle
  • FAYAD, Zahi A
  • SCHECTER, Alison D
  • BERMAN, Joan W
  • MANI, Venkatesh
  • SCHOENBAUM, Ellie E
  • KLEIN, Robert S
  • WEINSHELBAUM, Karen B
  • FUSTER, Valentin
  • HOWARD, Andrea A
  • YUNGTAI LO
subjects:
  • Aorta, Thoracic - pathology
  • Article
  • Atherosclerosis (general aspects, experimental research)
  • Atherosclerosis - complications
  • Atherosclerosis - diagnosis
  • Biological and medical sciences
  • Biomarkers - blood
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Carotid Arteries - pathology
  • Case-Control Studies
  • Chemokine CCL2 - blood
  • Cross-Sectional Studies
  • Female
  • HIV Infections - blood
  • HIV Infections - complications
  • HIV-1 - chemistry
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Infectious diseases
  • Magnetic Resonance Imaging
  • Male
  • Medical sciences
  • Middle Aged
  • New York
  • Prospective Studies
  • Risk Factors
  • Sexual Behavior
  • Substance Abuse, Intravenous - complications
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Viral Load
ispartof: AIDS (London), 2009, Vol.23 (8), p.941-949
description: HIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) levels and atherosclerosis burden. A cross-sectional analysis. : Serum MCP-1/CCL2, fasting lipids, and glucose tolerance were measured in 98 HIV-infected and 79 demographically similar uninfected adults. Eighty-four participants had MRI of the carotid arteries and thoracic aorta to measure atherosclerosis burden. Multivariate analyses were performed using linear regression. Mean MCP-1/CCL2 levels did not differ between HIV-infected and uninfected participants (P = 0.65). Among HIV-infected participants, after adjusting for age, BMI, and cigarette smoking, HIV-1 viral load was positively associated with MCP-1/CCL2 (P = 0.02). Multivariate analyses adjusting for sex, low-density lipoprotein cholesterol, total cholesterol:high-density lipoprotein cholesterol ratio, cigarette smoking, MCP-1/CCL2, and protease inhibitor use found that HIV infection was associated with greater mean thoracic aorta vessel wall area (VWA, P < 0.01) and vessel wall thickness (VWT, P = 0.03), but not with carotid artery parameters. Compared with being uninfected, having detectable HIV-1 viremia was associated with greater mean thoracic aorta VWA (P < 0.01) and VWT (P = 0.03), whereas being HIV-infected with undetectable viral load was associated with greater thoracic aorta VWA (P = 0.02) but not VWT (P = 0.15). There was an independent positive association of MCP-1/CCL2 with thoracic aorta VWA (P = 0.01) and VWT (P = 0.01). HIV-1 viral burden is associated with higher serum levels of MCP-1/CCL2 and with atherosclerosis burden, as assessed by thoracic aorta VWA and VWT.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleAssociation of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging
creatorFLORIS-MOORE, Michelle ; FAYAD, Zahi A ; SCHECTER, Alison D ; BERMAN, Joan W ; MANI, Venkatesh ; SCHOENBAUM, Ellie E ; KLEIN, Robert S ; WEINSHELBAUM, Karen B ; FUSTER, Valentin ; HOWARD, Andrea A ; YUNGTAI LO
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descriptionHIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) levels and atherosclerosis burden. A cross-sectional analysis. : Serum MCP-1/CCL2, fasting lipids, and glucose tolerance were measured in 98 HIV-infected and 79 demographically similar uninfected adults. Eighty-four participants had MRI of the carotid arteries and thoracic aorta to measure atherosclerosis burden. Multivariate analyses were performed using linear regression. Mean MCP-1/CCL2 levels did not differ between HIV-infected and uninfected participants (P = 0.65). Among HIV-infected participants, after adjusting for age, BMI, and cigarette smoking, HIV-1 viral load was positively associated with MCP-1/CCL2 (P = 0.02). Multivariate analyses adjusting for sex, low-density lipoprotein cholesterol, total cholesterol:high-density lipoprotein cholesterol ratio, cigarette smoking, MCP-1/CCL2, and protease inhibitor use found that HIV infection was associated with greater mean thoracic aorta vessel wall area (VWA, P < 0.01) and vessel wall thickness (VWT, P = 0.03), but not with carotid artery parameters. Compared with being uninfected, having detectable HIV-1 viremia was associated with greater mean thoracic aorta VWA (P < 0.01) and VWT (P = 0.03), whereas being HIV-infected with undetectable viral load was associated with greater thoracic aorta VWA (P = 0.02) but not VWT (P = 0.15). There was an independent positive association of MCP-1/CCL2 with thoracic aorta VWA (P = 0.01) and VWT (P = 0.01). HIV-1 viral burden is associated with higher serum levels of MCP-1/CCL2 and with atherosclerosis burden, as assessed by thoracic aorta VWA and VWT.
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languageeng
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subjectAorta, Thoracic - pathology ; Article ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - complications ; Atherosclerosis - diagnosis ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Arteries - pathology ; Case-Control Studies ; Chemokine CCL2 - blood ; Cross-Sectional Studies ; Female ; HIV Infections - blood ; HIV Infections - complications ; HIV-1 - chemistry ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; New York ; Prospective Studies ; Risk Factors ; Sexual Behavior ; Substance Abuse, Intravenous - complications ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load
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1FAYAD, Zahi A
2SCHECTER, Alison D
3BERMAN, Joan W
4MANI, Venkatesh
5SCHOENBAUM, Ellie E
6KLEIN, Robert S
7WEINSHELBAUM, Karen B
8FUSTER, Valentin
9HOWARD, Andrea A
10YUNGTAI LO
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0Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging
1AIDS (London)
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descriptionHIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) levels and atherosclerosis burden. A cross-sectional analysis. : Serum MCP-1/CCL2, fasting lipids, and glucose tolerance were measured in 98 HIV-infected and 79 demographically similar uninfected adults. Eighty-four participants had MRI of the carotid arteries and thoracic aorta to measure atherosclerosis burden. Multivariate analyses were performed using linear regression. Mean MCP-1/CCL2 levels did not differ between HIV-infected and uninfected participants (P = 0.65). Among HIV-infected participants, after adjusting for age, BMI, and cigarette smoking, HIV-1 viral load was positively associated with MCP-1/CCL2 (P = 0.02). Multivariate analyses adjusting for sex, low-density lipoprotein cholesterol, total cholesterol:high-density lipoprotein cholesterol ratio, cigarette smoking, MCP-1/CCL2, and protease inhibitor use found that HIV infection was associated with greater mean thoracic aorta vessel wall area (VWA, P < 0.01) and vessel wall thickness (VWT, P = 0.03), but not with carotid artery parameters. Compared with being uninfected, having detectable HIV-1 viremia was associated with greater mean thoracic aorta VWA (P < 0.01) and VWT (P = 0.03), whereas being HIV-infected with undetectable viral load was associated with greater thoracic aorta VWA (P = 0.02) but not VWT (P = 0.15). There was an independent positive association of MCP-1/CCL2 with thoracic aorta VWA (P = 0.01) and VWT (P = 0.01). HIV-1 viral burden is associated with higher serum levels of MCP-1/CCL2 and with atherosclerosis burden, as assessed by thoracic aorta VWA and VWT.
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0Aorta, Thoracic - pathology
1Article
2Atherosclerosis (general aspects, experimental research)
3Atherosclerosis - complications
4Atherosclerosis - diagnosis
5Biological and medical sciences
6Biomarkers - blood
7Blood and lymphatic vessels
8Cardiology. Vascular system
9Carotid Arteries - pathology
10Case-Control Studies
11Chemokine CCL2 - blood
12Cross-Sectional Studies
13Female
14HIV Infections - blood
15HIV Infections - complications
16HIV-1 - chemistry
17Human immunodeficiency virus 1
18Human viral diseases
19Humans
20Immunodeficiencies
21Immunodeficiencies. Immunoglobulinopathies
22Immunopathology
23Infectious diseases
24Magnetic Resonance Imaging
25Male
26Medical sciences
27Middle Aged
28New York
29Prospective Studies
30Risk Factors
31Sexual Behavior
32Substance Abuse, Intravenous - complications
33Viral diseases
34Viral diseases of the lymphoid tissue and the blood. Aids
35Viral Load
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titleAssociation of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging
authorFLORIS-MOORE, Michelle ; FAYAD, Zahi A ; SCHECTER, Alison D ; BERMAN, Joan W ; MANI, Venkatesh ; SCHOENBAUM, Ellie E ; KLEIN, Robert S ; WEINSHELBAUM, Karen B ; FUSTER, Valentin ; HOWARD, Andrea A ; YUNGTAI LO
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0Aorta, Thoracic - pathology
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2Atherosclerosis (general aspects, experimental research)
3Atherosclerosis - complications
4Atherosclerosis - diagnosis
5Biological and medical sciences
6Biomarkers - blood
7Blood and lymphatic vessels
8Cardiology. Vascular system
9Carotid Arteries - pathology
10Case-Control Studies
11Chemokine CCL2 - blood
12Cross-Sectional Studies
13Female
14HIV Infections - blood
15HIV Infections - complications
16HIV-1 - chemistry
17Human immunodeficiency virus 1
18Human viral diseases
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20Immunodeficiencies
21Immunodeficiencies. Immunoglobulinopathies
22Immunopathology
23Infectious diseases
24Magnetic Resonance Imaging
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26Medical sciences
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28New York
29Prospective Studies
30Risk Factors
31Sexual Behavior
32Substance Abuse, Intravenous - complications
33Viral diseases
34Viral diseases of the lymphoid tissue and the blood. Aids
35Viral Load
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1FAYAD, Zahi A
2SCHECTER, Alison D
3BERMAN, Joan W
4MANI, Venkatesh
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9HOWARD, Andrea A
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1FAYAD, Zahi A
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6KLEIN, Robert S
7WEINSHELBAUM, Karen B
8FUSTER, Valentin
9HOWARD, Andrea A
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atitleAssociation of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging
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date2009
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volume23
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spage941
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pages941-949
issn0269-9370
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abstractHIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) levels and atherosclerosis burden. A cross-sectional analysis. : Serum MCP-1/CCL2, fasting lipids, and glucose tolerance were measured in 98 HIV-infected and 79 demographically similar uninfected adults. Eighty-four participants had MRI of the carotid arteries and thoracic aorta to measure atherosclerosis burden. Multivariate analyses were performed using linear regression. Mean MCP-1/CCL2 levels did not differ between HIV-infected and uninfected participants (P = 0.65). Among HIV-infected participants, after adjusting for age, BMI, and cigarette smoking, HIV-1 viral load was positively associated with MCP-1/CCL2 (P = 0.02). Multivariate analyses adjusting for sex, low-density lipoprotein cholesterol, total cholesterol:high-density lipoprotein cholesterol ratio, cigarette smoking, MCP-1/CCL2, and protease inhibitor use found that HIV infection was associated with greater mean thoracic aorta vessel wall area (VWA, P < 0.01) and vessel wall thickness (VWT, P = 0.03), but not with carotid artery parameters. Compared with being uninfected, having detectable HIV-1 viremia was associated with greater mean thoracic aorta VWA (P < 0.01) and VWT (P = 0.03), whereas being HIV-infected with undetectable viral load was associated with greater thoracic aorta VWA (P = 0.02) but not VWT (P = 0.15). There was an independent positive association of MCP-1/CCL2 with thoracic aorta VWA (P = 0.01) and VWT (P = 0.01). HIV-1 viral burden is associated with higher serum levels of MCP-1/CCL2 and with atherosclerosis burden, as assessed by thoracic aorta VWA and VWT.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid19318907
doi10.1097/QAD.0b013e328329c76b
oafree_for_read