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Inferring Genetic Ancestry: Opportunities, Challenges, and Implications

Increasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been accompanied by growing concern about issues ranging from the personal and societal implications of the testing to the scientific validity of ancestry inference. The very concept of “ancestry” is subject to misun... Full description

Journal Title: American journal of human genetics 2010, Vol.86 (5), p.661-673
Main Author: Royal, Charmaine D
Other Authors: Novembre, John , Fullerton, Stephanie M , Goldstein, David B , Long, Jeffrey C , Bamshad, Michael J , Clark, Andrew G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Cambridge, MA: Elsevier Inc
ID: ISSN: 0002-9297
Zum Text:
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2869013
title: Inferring Genetic Ancestry: Opportunities, Challenges, and Implications
format: Article
creator:
  • Royal, Charmaine D
  • Novembre, John
  • Fullerton, Stephanie M
  • Goldstein, David B
  • Long, Jeffrey C
  • Bamshad, Michael J
  • Clark, Andrew G
subjects:
  • Biological and medical sciences
  • Commentary
  • European Continental Ancestry Group - genetics
  • Evaluation
  • Fundamental and applied biological sciences. Psychology
  • Genealogy
  • General aspects. Genetic counseling
  • Genes
  • Genetic engineering
  • Genetic research
  • Genetic Research - ethics
  • Genetic screening
  • Genetic testing
  • Genetic Testing - standards
  • Genetics
  • Genetics of eukaryotes. Biological and molecular evolution
  • Genetics(clinical)
  • Humans
  • Medical genetics
  • Medical sciences
  • Molecular and cellular biology
  • Patients - psychology
  • Reports
  • Standards
  • Trade and professional associations
ispartof: American journal of human genetics, 2010, Vol.86 (5), p.661-673
description: Increasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been accompanied by growing concern about issues ranging from the personal and societal implications of the testing to the scientific validity of ancestry inference. The very concept of “ancestry” is subject to misunderstanding in both the general and scientific communities. What do we mean by ancestry? How exactly is ancestry measured? How far back can such ancestry be defined and by which genetic tools? How do we validate inferences about ancestry in genetic research? What are the data that demonstrate our ability to do this correctly? What can we say and what can we not say from our research findings and the test results that we generate? This white paper from the American Society of Human Genetics (ASHG) Ancestry and Ancestry Testing Task Force builds upon the 2008 ASHG Ancestry Testing Summary Statement in providing a more in-depth analysis of key scientific and non-scientific aspects of genetic ancestry inference in academia and industry. It culminates with recommendations for advancing the current debate and facilitating the development of scientifically based, ethically sound, and socially attentive guidelines concerning the use of these continually evolving technologies.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-9297
fulltext: fulltext
issn:
  • 0002-9297
  • 1537-6605
url: Link


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descriptionIncreasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been accompanied by growing concern about issues ranging from the personal and societal implications of the testing to the scientific validity of ancestry inference. The very concept of “ancestry” is subject to misunderstanding in both the general and scientific communities. What do we mean by ancestry? How exactly is ancestry measured? How far back can such ancestry be defined and by which genetic tools? How do we validate inferences about ancestry in genetic research? What are the data that demonstrate our ability to do this correctly? What can we say and what can we not say from our research findings and the test results that we generate? This white paper from the American Society of Human Genetics (ASHG) Ancestry and Ancestry Testing Task Force builds upon the 2008 ASHG Ancestry Testing Summary Statement in providing a more in-depth analysis of key scientific and non-scientific aspects of genetic ancestry inference in academia and industry. It culminates with recommendations for advancing the current debate and facilitating the development of scientifically based, ethically sound, and socially attentive guidelines concerning the use of these continually evolving technologies.
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subjectBiological and medical sciences ; Commentary ; European Continental Ancestry Group - genetics ; Evaluation ; Fundamental and applied biological sciences. Psychology ; Genealogy ; General aspects. Genetic counseling ; Genes ; Genetic engineering ; Genetic research ; Genetic Research - ethics ; Genetic screening ; Genetic testing ; Genetic Testing - standards ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genetics(clinical) ; Humans ; Medical genetics ; Medical sciences ; Molecular and cellular biology ; Patients - psychology ; Reports ; Standards ; Trade and professional associations
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descriptionIncreasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been accompanied by growing concern about issues ranging from the personal and societal implications of the testing to the scientific validity of ancestry inference. The very concept of “ancestry” is subject to misunderstanding in both the general and scientific communities. What do we mean by ancestry? How exactly is ancestry measured? How far back can such ancestry be defined and by which genetic tools? How do we validate inferences about ancestry in genetic research? What are the data that demonstrate our ability to do this correctly? What can we say and what can we not say from our research findings and the test results that we generate? This white paper from the American Society of Human Genetics (ASHG) Ancestry and Ancestry Testing Task Force builds upon the 2008 ASHG Ancestry Testing Summary Statement in providing a more in-depth analysis of key scientific and non-scientific aspects of genetic ancestry inference in academia and industry. It culminates with recommendations for advancing the current debate and facilitating the development of scientifically based, ethically sound, and socially attentive guidelines concerning the use of these continually evolving technologies.
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abstractIncreasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been accompanied by growing concern about issues ranging from the personal and societal implications of the testing to the scientific validity of ancestry inference. The very concept of “ancestry” is subject to misunderstanding in both the general and scientific communities. What do we mean by ancestry? How exactly is ancestry measured? How far back can such ancestry be defined and by which genetic tools? How do we validate inferences about ancestry in genetic research? What are the data that demonstrate our ability to do this correctly? What can we say and what can we not say from our research findings and the test results that we generate? This white paper from the American Society of Human Genetics (ASHG) Ancestry and Ancestry Testing Task Force builds upon the 2008 ASHG Ancestry Testing Summary Statement in providing a more in-depth analysis of key scientific and non-scientific aspects of genetic ancestry inference in academia and industry. It culminates with recommendations for advancing the current debate and facilitating the development of scientifically based, ethically sound, and socially attentive guidelines concerning the use of these continually evolving technologies.
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