schliessen

Filtern

 

Bibliotheken

Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources

We use silkworms to evaluate therapeutic effects of drug candidates. Our previous reports have revealed that there are common mechanisms of pharmacokinetics of chemicals in silkworms and mammals. In this report, we attempt to establish a method by using silkworms to identify chemicals from plant ext... Full description

Journal Title: BMC Pharmacology 2010-06-11, Vol.10 (1), p.7-7
Main Author: Asami, Yukihiro
Other Authors: Horie, Ryo , Hamamoto, Hiroshi , Sekimizu, Kazuhisa
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BioMed Central Ltd
ID: ISSN: 1471-2210
Link: https://www.ncbi.nlm.nih.gov/pubmed/20537191
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2898707
title: Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources
format: Article
creator:
  • Asami, Yukihiro
  • Horie, Ryo
  • Hamamoto, Hiroshi
  • Sekimizu, Kazuhisa
subjects:
  • Animals
  • Antibiotics
  • Bombyx - metabolism
  • Bombyx mori
  • Chromatography
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Flavones - blood
  • Flavones - pharmacokinetics
  • Flavones - therapeutic use
  • Flavonoids - blood
  • Flavonoids - pharmacokinetics
  • Flavonoids - therapeutic use
  • fungi
  • Hemolymph - metabolism
  • Mass Spectrometry
  • Materia medica, Vegetable
  • Medicine, Botanic
  • Medicine, Herbal
  • Methodology article
  • Models, Animal
  • Pharmacokinetics
  • Pharmacology
  • Pharmacology (medical)
  • Physiological aspects
  • Plant extracts
  • Plant Extracts - pharmacokinetics
  • Properties
  • Scientific imaging
  • Silkworms
  • Usage
ispartof: BMC Pharmacology, 2010-06-11, Vol.10 (1), p.7-7
description: We use silkworms to evaluate therapeutic effects of drug candidates. Our previous reports have revealed that there are common mechanisms of pharmacokinetics of chemicals in silkworms and mammals. In this report, we attempt to establish a method by using silkworms to identify chemicals from plant extracts which are absorbed from intestine and also stably exist in body fluids. Three compounds were detected in the silkworm hemolymph by HPLC analysis after midgut injection of acetone extracts of seihi, an herbal medicine obtained from orange peel. Analyses with MS and NMR revealed that the compounds were nobiletin, heptamethoxyflavone, and tangeretin. These compounds are reported to be stable in mammalian blood. The half-life of each of these compounds in the silkworm hemolymph was 18, 26 and 34 h, respectively. These findings suggest that silkworms can be used as a model animal to easily identify compounds with appropriate pharmacokinetic behavior.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1471-2210
fulltext: fulltext
issn:
  • 1471-2210
  • 1471-2210
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.089575
LOCALfalse
PrimoNMBib
record
control
sourceidgale_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2898707
sourceformatXML
sourcesystemPC
galeidA230895922
sourcerecordidA230895922
originalsourceidFETCH-LOGICAL-15673-b7541ec2fd460a88783b01fc12a0de60705d3ff78cdc44ce613fad63ed41930b3
addsrcrecordideNp1Uk1v1DAQjRCIlsKVI4rEgdMWO3Zi54K0qviSKrjQs-XY4123iR3spBX_nglblm5pZUu2Zp6f35uZonhNySmlsnlPuaCrqqJkhVs8KY73gad37kfFi5wvCaFCcvG8OKpIzQRt6XExXGQooyuz769uYhpy6WIqvYUweeeNnnwMS96meVMaHay3eoJcbvW1D5tSj2OKY_IYK8etToM28coHmLxBphSHcux1mMoc52QgvyyeOd1neHV7nhQXnz7-OPuyOv_--evZ-nxF60awVSdqTsFUzvKGaCmFZB2hztBKEwsNEaS2zDkhjTWcG2goc9o2DCynLSMdOyk-7HjHuRvAGnSTdK9Q6KDTLxW1V4eZ4LdqE69VJVspiECCbzuCOELQPsHBW4sGlQU7j-rGKSyrqhkXTrrWUJBCaNcQ3jFtURyhprMVEq53hJ2Pjyg6zJg4qKV_aumfwr2IenfrKsWfM-RJDT4b6LHCEOessGr4OWtrRL69h7zEBgQsuaINFwwLyug_1Eb3oHxwEX82C6daV4zItm6rRfnpAyhcFgZvYgDnMf7QA5Nizgnc3uViBIf2f19v7nZrD_87pQjg9xiNn_6MJkrx_WO8vwEAvfj7
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1647378331
display
typearticle
titleUse of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources
sourceAlma/SFX Local Collection
creatorAsami, Yukihiro ; Horie, Ryo ; Hamamoto, Hiroshi ; Sekimizu, Kazuhisa
creatorcontribAsami, Yukihiro ; Horie, Ryo ; Hamamoto, Hiroshi ; Sekimizu, Kazuhisa
descriptionWe use silkworms to evaluate therapeutic effects of drug candidates. Our previous reports have revealed that there are common mechanisms of pharmacokinetics of chemicals in silkworms and mammals. In this report, we attempt to establish a method by using silkworms to identify chemicals from plant extracts which are absorbed from intestine and also stably exist in body fluids. Three compounds were detected in the silkworm hemolymph by HPLC analysis after midgut injection of acetone extracts of seihi, an herbal medicine obtained from orange peel. Analyses with MS and NMR revealed that the compounds were nobiletin, heptamethoxyflavone, and tangeretin. These compounds are reported to be stable in mammalian blood. The half-life of each of these compounds in the silkworm hemolymph was 18, 26 and 34 h, respectively. These findings suggest that silkworms can be used as a model animal to easily identify compounds with appropriate pharmacokinetic behavior.
identifier
0ISSN: 1471-2210
1EISSN: 1471-2210
2DOI: 10.1186/1471-2210-10-7
3PMID: 20537191
languageeng
publisherEngland: BioMed Central Ltd
subjectAnimals ; Antibiotics ; Bombyx - metabolism ; Bombyx mori ; Chromatography ; Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Flavones - blood ; Flavones - pharmacokinetics ; Flavones - therapeutic use ; Flavonoids - blood ; Flavonoids - pharmacokinetics ; Flavonoids - therapeutic use ; fungi ; Hemolymph - metabolism ; Mass Spectrometry ; Materia medica, Vegetable ; Medicine, Botanic ; Medicine, Herbal ; Methodology article ; Models, Animal ; Pharmacokinetics ; Pharmacology ; Pharmacology (medical) ; Physiological aspects ; Plant extracts ; Plant Extracts - pharmacokinetics ; Properties ; Scientific imaging ; Silkworms ; Usage
ispartofBMC Pharmacology, 2010-06-11, Vol.10 (1), p.7-7
rights
0COPYRIGHT 2010 BioMed Central Ltd.
1Copyright ©2010 Asami et al; licensee BioMed Central Ltd. 2010 Asami et al; licensee BioMed Central Ltd.
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-15673-b7541ec2fd460a88783b01fc12a0de60705d3ff78cdc44ce613fad63ed41930b3
citesFETCH-LOGICAL-15673-b7541ec2fd460a88783b01fc12a0de60705d3ff78cdc44ce613fad63ed41930b3
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20537191$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Asami, Yukihiro
1Horie, Ryo
2Hamamoto, Hiroshi
3Sekimizu, Kazuhisa
title
0Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources
1BMC Pharmacology
addtitleBMC Pharmacol
descriptionWe use silkworms to evaluate therapeutic effects of drug candidates. Our previous reports have revealed that there are common mechanisms of pharmacokinetics of chemicals in silkworms and mammals. In this report, we attempt to establish a method by using silkworms to identify chemicals from plant extracts which are absorbed from intestine and also stably exist in body fluids. Three compounds were detected in the silkworm hemolymph by HPLC analysis after midgut injection of acetone extracts of seihi, an herbal medicine obtained from orange peel. Analyses with MS and NMR revealed that the compounds were nobiletin, heptamethoxyflavone, and tangeretin. These compounds are reported to be stable in mammalian blood. The half-life of each of these compounds in the silkworm hemolymph was 18, 26 and 34 h, respectively. These findings suggest that silkworms can be used as a model animal to easily identify compounds with appropriate pharmacokinetic behavior.
subject
0Animals
1Antibiotics
2Bombyx - metabolism
3Bombyx mori
4Chromatography
5Chromatography, High Pressure Liquid
6Chromatography, Thin Layer
7Flavones - blood
8Flavones - pharmacokinetics
9Flavones - therapeutic use
10Flavonoids - blood
11Flavonoids - pharmacokinetics
12Flavonoids - therapeutic use
13fungi
14Hemolymph - metabolism
15Mass Spectrometry
16Materia medica, Vegetable
17Medicine, Botanic
18Medicine, Herbal
19Methodology article
20Models, Animal
21Pharmacokinetics
22Pharmacology
23Pharmacology (medical)
24Physiological aspects
25Plant extracts
26Plant Extracts - pharmacokinetics
27Properties
28Scientific imaging
29Silkworms
30Usage
issn
01471-2210
11471-2210
fulltexttrue
rsrctypearticle
creationdate2010
recordtypearticle
recordideNp1Uk1v1DAQjRCIlsKVI4rEgdMWO3Zi54K0qviSKrjQs-XY4123iR3spBX_nglblm5pZUu2Zp6f35uZonhNySmlsnlPuaCrqqJkhVs8KY73gad37kfFi5wvCaFCcvG8OKpIzQRt6XExXGQooyuz769uYhpy6WIqvYUweeeNnnwMS96meVMaHay3eoJcbvW1D5tSj2OKY_IYK8etToM28coHmLxBphSHcux1mMoc52QgvyyeOd1neHV7nhQXnz7-OPuyOv_--evZ-nxF60awVSdqTsFUzvKGaCmFZB2hztBKEwsNEaS2zDkhjTWcG2goc9o2DCynLSMdOyk-7HjHuRvAGnSTdK9Q6KDTLxW1V4eZ4LdqE69VJVspiECCbzuCOELQPsHBW4sGlQU7j-rGKSyrqhkXTrrWUJBCaNcQ3jFtURyhprMVEq53hJ2Pjyg6zJg4qKV_aumfwr2IenfrKsWfM-RJDT4b6LHCEOessGr4OWtrRL69h7zEBgQsuaINFwwLyug_1Eb3oHxwEX82C6daV4zItm6rRfnpAyhcFgZvYgDnMf7QA5Nizgnc3uViBIf2f19v7nZrD_87pQjg9xiNn_6MJkrx_WO8vwEAvfj7
startdate20100611
enddate20100611
creator
0Asami, Yukihiro
1Horie, Ryo
2Hamamoto, Hiroshi
3Sekimizu, Kazuhisa
general
0BioMed Central Ltd
1BioMed Central
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
83V.
97X7
107XB
1188E
128AO
138FI
148FJ
158FK
16ABUWG
17BENPR
18FYUFA
19GHDGH
20K9.
21M0S
22M1P
23PQEST
24PQQKQ
25PQUKI
26PRINS
277SS
28BOBZL
29CLFQK
305PM
sort
creationdate20100611
titleUse of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources
authorAsami, Yukihiro ; Horie, Ryo ; Hamamoto, Hiroshi ; Sekimizu, Kazuhisa
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-15673-b7541ec2fd460a88783b01fc12a0de60705d3ff78cdc44ce613fad63ed41930b3
rsrctypearticles
prefilterarticles
languageeng
creationdate2010
topic
0Animals
1Antibiotics
2Bombyx - metabolism
3Bombyx mori
4Chromatography
5Chromatography, High Pressure Liquid
6Chromatography, Thin Layer
7Flavones - blood
8Flavones - pharmacokinetics
9Flavones - therapeutic use
10Flavonoids - blood
11Flavonoids - pharmacokinetics
12Flavonoids - therapeutic use
13fungi
14Hemolymph - metabolism
15Mass Spectrometry
16Materia medica, Vegetable
17Medicine, Botanic
18Medicine, Herbal
19Methodology article
20Models, Animal
21Pharmacokinetics
22Pharmacology
23Pharmacology (medical)
24Physiological aspects
25Plant extracts
26Plant Extracts - pharmacokinetics
27Properties
28Scientific imaging
29Silkworms
30Usage
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Asami, Yukihiro
1Horie, Ryo
2Hamamoto, Hiroshi
3Sekimizu, Kazuhisa
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7ProQuest Central (Corporate)
8Health & Medical Collection
9ProQuest Central (purchase pre-March 2016)
10Medical Database (Alumni Edition)
11ProQuest Pharma Collection
12Hospital Premium Collection
13Hospital Premium Collection (Alumni Edition)
14ProQuest Central (Alumni) (purchase pre-March 2016)
15ProQuest Central (Alumni Edition)
16ProQuest Central
17Health Research Premium Collection
18Health Research Premium Collection (Alumni)
19ProQuest Health & Medical Complete (Alumni)
20Health & Medical Collection (Alumni Edition)
21Medical Database
22ProQuest One Academic Eastern Edition
23ProQuest One Academic
24ProQuest One Academic UKI Edition
25ProQuest Central China
26Entomology Abstracts (Full archive)
27OpenAIRE (Open Access)
28OpenAIRE
29PubMed Central (Full Participant titles)
jtitleBMC Pharmacology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Asami, Yukihiro
1Horie, Ryo
2Hamamoto, Hiroshi
3Sekimizu, Kazuhisa
formatjournal
genrearticle
ristypeJOUR
atitleUse of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources
jtitleBMC Pharmacology
addtitleBMC Pharmacol
date2010-06-11
risdate2010
volume10
issue1
spage7
epage7
pages7-7
issn1471-2210
eissn1471-2210
abstractWe use silkworms to evaluate therapeutic effects of drug candidates. Our previous reports have revealed that there are common mechanisms of pharmacokinetics of chemicals in silkworms and mammals. In this report, we attempt to establish a method by using silkworms to identify chemicals from plant extracts which are absorbed from intestine and also stably exist in body fluids. Three compounds were detected in the silkworm hemolymph by HPLC analysis after midgut injection of acetone extracts of seihi, an herbal medicine obtained from orange peel. Analyses with MS and NMR revealed that the compounds were nobiletin, heptamethoxyflavone, and tangeretin. These compounds are reported to be stable in mammalian blood. The half-life of each of these compounds in the silkworm hemolymph was 18, 26 and 34 h, respectively. These findings suggest that silkworms can be used as a model animal to easily identify compounds with appropriate pharmacokinetic behavior.
copEngland
pubBioMed Central Ltd
pmid20537191
doi10.1186/1471-2210-10-7
oafree_for_read