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HIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda

To determine whether heterosexual transmission of HIV differs according to HIV-1 subtype. A retrospective observational cohort. HIV-1 subtype effects on heterosexual HIV-1 transmission were determined among 268 HIV-discordant couples retrospectively identified from a population cohort in Rakai, Ugan... Full description

Journal Title: AIDS (London) 2009, Vol.23 (18), p.2479-2484
Main Author: KIWANUKA, Noah
Other Authors: LAEYENDECKER, Oliver , REYNOLDS, Steven J , GRAY, Ronald H , QUINN, Thomas C , WAWER, Maria J , SHEPHERD, James , ROBB, Merlin , KIGOZI, Godfrey , KAGAAYI, Joseph , SERWADDA, David , MAKUMBI, Fred E
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2910931
title: HIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda
format: Article
creator:
  • KIWANUKA, Noah
  • LAEYENDECKER, Oliver
  • REYNOLDS, Steven J
  • GRAY, Ronald H
  • QUINN, Thomas C
  • WAWER, Maria J
  • SHEPHERD, James
  • ROBB, Merlin
  • KIGOZI, Godfrey
  • KAGAAYI, Joseph
  • SERWADDA, David
  • MAKUMBI, Fred E
subjects:
  • Adolescent
  • Adult
  • Age
  • AIDS/HIV
  • Article
  • Biological and medical sciences
  • Coitus
  • Condoms
  • discordant couples
  • Disease transmission
  • Epidemics
  • Female
  • Gag protein
  • glycoprotein gp41
  • Heterosexuality
  • HIV Infections - epidemiology
  • HIV Infections - immunology
  • HIV Infections - transmission
  • HIV Seronegativity
  • HIV transmission
  • HIV-1 - classification
  • HIV-1 - immunology
  • HIV-1 subtype
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Infectious diseases
  • Male
  • Medical sciences
  • Middle Aged
  • Polymerase chain reaction
  • Retrospective Studies
  • Risk Factors
  • RNA-directed DNA polymerase
  • Sexual Partners
  • Surveys and Questionnaires
  • Uganda
  • Uganda - epidemiology
  • Ulcers
  • Vaccines
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Viral Load
  • Young Adult
ispartof: AIDS (London), 2009, Vol.23 (18), p.2479-2484
description: To determine whether heterosexual transmission of HIV differs according to HIV-1 subtype. A retrospective observational cohort. HIV-1 subtype effects on heterosexual HIV-1 transmission were determined among 268 HIV-discordant couples retrospectively identified from a population cohort in Rakai, Uganda. HIV-1 subtype (gag and gp41 sequencing and multiregion hybridization assay) and viral loads (reverse transcriptase PCR) were determined. Adjusted incidence rate ratios (adj IRR) of HIV transmission by subtype were estimated by multivariable Poisson regression adjusting for characteristics of index HIV-positive and HIV-negative partners. Adjusting for index HIV-positive partners' age, viral load, stage of disease, genital ulcer disease, and HIV-negative partners' genital ulcer disease and nonuse of condoms, subtype A viruses were associated with a higher rate of transmission than subtype D [adj.IRR 1.98, 95% confidence interval (CI) 1.17-3.34], but no differences in transmission were observed between recombinant viruses and subtype D (aIRR 1.53, P = 0.25). Index-positive partners' age less than 30 years (adj.IRR 3.44, 95% CI 1.75-6.78) and viral load (adj.IRR 2.37, 95% CI 1.75-3.21), and index-negative partners' genital ulcer disease (adj.IRR 1.71, 95% CI 1.08-2.70) and nonuse of condoms (adj.IRR 1.94, 95% CI 1.15-3.28) were significant determinants of HIV transmission. In Rakai, Uganda, subtype A viruses have a significantly higher rate of heterosexual transmission than subtype D viruses. Differential subtype transmission efficiency may be important for HIV vaccine evaluation and could contribute to subtype-specific HIV epidemics in sub-Saharan Africa.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleHIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda
creatorKIWANUKA, Noah ; LAEYENDECKER, Oliver ; REYNOLDS, Steven J ; GRAY, Ronald H ; QUINN, Thomas C ; WAWER, Maria J ; SHEPHERD, James ; ROBB, Merlin ; KIGOZI, Godfrey ; KAGAAYI, Joseph ; SERWADDA, David ; MAKUMBI, Fred E
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descriptionTo determine whether heterosexual transmission of HIV differs according to HIV-1 subtype. A retrospective observational cohort. HIV-1 subtype effects on heterosexual HIV-1 transmission were determined among 268 HIV-discordant couples retrospectively identified from a population cohort in Rakai, Uganda. HIV-1 subtype (gag and gp41 sequencing and multiregion hybridization assay) and viral loads (reverse transcriptase PCR) were determined. Adjusted incidence rate ratios (adj IRR) of HIV transmission by subtype were estimated by multivariable Poisson regression adjusting for characteristics of index HIV-positive and HIV-negative partners. Adjusting for index HIV-positive partners' age, viral load, stage of disease, genital ulcer disease, and HIV-negative partners' genital ulcer disease and nonuse of condoms, subtype A viruses were associated with a higher rate of transmission than subtype D [adj.IRR 1.98, 95% confidence interval (CI) 1.17-3.34], but no differences in transmission were observed between recombinant viruses and subtype D (aIRR 1.53, P = 0.25). Index-positive partners' age less than 30 years (adj.IRR 3.44, 95% CI 1.75-6.78) and viral load (adj.IRR 2.37, 95% CI 1.75-3.21), and index-negative partners' genital ulcer disease (adj.IRR 1.71, 95% CI 1.08-2.70) and nonuse of condoms (adj.IRR 1.94, 95% CI 1.15-3.28) were significant determinants of HIV transmission. In Rakai, Uganda, subtype A viruses have a significantly higher rate of heterosexual transmission than subtype D viruses. Differential subtype transmission efficiency may be important for HIV vaccine evaluation and could contribute to subtype-specific HIV epidemics in sub-Saharan Africa.
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subjectAdolescent ; Adult ; Age ; AIDS/HIV ; Article ; Biological and medical sciences ; Coitus ; Condoms ; discordant couples ; Disease transmission ; Epidemics ; Female ; Gag protein ; glycoprotein gp41 ; Heterosexuality ; HIV Infections - epidemiology ; HIV Infections - immunology ; HIV Infections - transmission ; HIV Seronegativity ; HIV transmission ; HIV-1 - classification ; HIV-1 - immunology ; HIV-1 subtype ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Polymerase chain reaction ; Retrospective Studies ; Risk Factors ; RNA-directed DNA polymerase ; Sexual Partners ; Surveys and Questionnaires ; Uganda ; Uganda - epidemiology ; Ulcers ; Vaccines ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Young Adult
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8KIGOZI, Godfrey
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0HIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda
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descriptionTo determine whether heterosexual transmission of HIV differs according to HIV-1 subtype. A retrospective observational cohort. HIV-1 subtype effects on heterosexual HIV-1 transmission were determined among 268 HIV-discordant couples retrospectively identified from a population cohort in Rakai, Uganda. HIV-1 subtype (gag and gp41 sequencing and multiregion hybridization assay) and viral loads (reverse transcriptase PCR) were determined. Adjusted incidence rate ratios (adj IRR) of HIV transmission by subtype were estimated by multivariable Poisson regression adjusting for characteristics of index HIV-positive and HIV-negative partners. Adjusting for index HIV-positive partners' age, viral load, stage of disease, genital ulcer disease, and HIV-negative partners' genital ulcer disease and nonuse of condoms, subtype A viruses were associated with a higher rate of transmission than subtype D [adj.IRR 1.98, 95% confidence interval (CI) 1.17-3.34], but no differences in transmission were observed between recombinant viruses and subtype D (aIRR 1.53, P = 0.25). Index-positive partners' age less than 30 years (adj.IRR 3.44, 95% CI 1.75-6.78) and viral load (adj.IRR 2.37, 95% CI 1.75-3.21), and index-negative partners' genital ulcer disease (adj.IRR 1.71, 95% CI 1.08-2.70) and nonuse of condoms (adj.IRR 1.94, 95% CI 1.15-3.28) were significant determinants of HIV transmission. In Rakai, Uganda, subtype A viruses have a significantly higher rate of heterosexual transmission than subtype D viruses. Differential subtype transmission efficiency may be important for HIV vaccine evaluation and could contribute to subtype-specific HIV epidemics in sub-Saharan Africa.
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17HIV Infections - transmission
18HIV Seronegativity
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21HIV-1 - immunology
22HIV-1 subtype
23Human immunodeficiency virus 1
24Human viral diseases
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28Immunopathology
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titleHIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda
authorKIWANUKA, Noah ; LAEYENDECKER, Oliver ; REYNOLDS, Steven J ; GRAY, Ronald H ; QUINN, Thomas C ; WAWER, Maria J ; SHEPHERD, James ; ROBB, Merlin ; KIGOZI, Godfrey ; KAGAAYI, Joseph ; SERWADDA, David ; MAKUMBI, Fred E
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abstractTo determine whether heterosexual transmission of HIV differs according to HIV-1 subtype. A retrospective observational cohort. HIV-1 subtype effects on heterosexual HIV-1 transmission were determined among 268 HIV-discordant couples retrospectively identified from a population cohort in Rakai, Uganda. HIV-1 subtype (gag and gp41 sequencing and multiregion hybridization assay) and viral loads (reverse transcriptase PCR) were determined. Adjusted incidence rate ratios (adj IRR) of HIV transmission by subtype were estimated by multivariable Poisson regression adjusting for characteristics of index HIV-positive and HIV-negative partners. Adjusting for index HIV-positive partners' age, viral load, stage of disease, genital ulcer disease, and HIV-negative partners' genital ulcer disease and nonuse of condoms, subtype A viruses were associated with a higher rate of transmission than subtype D [adj.IRR 1.98, 95% confidence interval (CI) 1.17-3.34], but no differences in transmission were observed between recombinant viruses and subtype D (aIRR 1.53, P = 0.25). Index-positive partners' age less than 30 years (adj.IRR 3.44, 95% CI 1.75-6.78) and viral load (adj.IRR 2.37, 95% CI 1.75-3.21), and index-negative partners' genital ulcer disease (adj.IRR 1.71, 95% CI 1.08-2.70) and nonuse of condoms (adj.IRR 1.94, 95% CI 1.15-3.28) were significant determinants of HIV transmission. In Rakai, Uganda, subtype A viruses have a significantly higher rate of heterosexual transmission than subtype D viruses. Differential subtype transmission efficiency may be important for HIV vaccine evaluation and could contribute to subtype-specific HIV epidemics in sub-Saharan Africa.
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