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Antiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs

Resistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected... Full description

Journal Title: AIDS research and human retroviruses 2008, Vol.24 (6), p.797-804
Main Author: Soto-Ramirez, Luis E.
Other Authors: Rodriguez-Diaz, Roberto , Durán, Adriana S. , Losso, Marcelo H. , Salomón, Horacio , Gómez-Carrillo, Manuel , Pampuro, Sandra , Harris, D. Robert , Duarte, Geraldo , De Souza, Ricardo S. , Read, Jennifer S.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Larchmont, NY: Mary Ann Liebert, Inc
ID: ISSN: 0889-2229
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2928544
title: Antiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
format: Article
creator:
  • Soto-Ramirez, Luis E.
  • Rodriguez-Diaz, Roberto
  • Durán, Adriana S.
  • Losso, Marcelo H.
  • Salomón, Horacio
  • Gómez-Carrillo, Manuel
  • Pampuro, Sandra
  • Harris, D. Robert
  • Duarte, Geraldo
  • De Souza, Ricardo S.
  • Read, Jennifer S.
subjects:
  • AIDS/HIV
  • Anti-HIV Agents - therapeutic use
  • Biological and medical sciences
  • Care and treatment
  • Caribbean Region - epidemiology
  • Clinical Studies
  • Clinical Trials
  • CLINICAL TRIALS/CLINICAL STUDIES
  • Diagnosis
  • Drug resistance in microorganisms
  • Drug Resistance, Multiple, Viral - genetics
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Gene mutations
  • Genetic aspects
  • Genotype
  • Health aspects
  • HIV infection
  • HIV infection in pregnancy
  • HIV Infections - drug therapy
  • HIV Infections - epidemiology
  • HIV Infections - transmission
  • HIV-1 - drug effects
  • HIV-1 - genetics
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Infectious Disease Transmission, Vertical - prevention & control
  • Infectious diseases
  • Latin America - epidemiology
  • Leukocytes, Mononuclear - virology
  • Medical sciences
  • Microbiology
  • Miscellaneous
  • Mutation
  • Patient Selection
  • Pregnancy
  • Pregnancy Complications, Infectious - drug therapy
  • Pregnancy Complications, Infectious - epidemiology
  • Pregnancy Complications, Infectious - virology
  • Prospective Studies
  • Retrovirus
  • Risk factors
  • RNA, Viral - blood
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Viral Load
  • Virology
ispartof: AIDS research and human retroviruses, 2008, Vol.24 (6), p.797-804
description: Resistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6–12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6–12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6–12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7–25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (>15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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titleAntiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
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creatorSoto-Ramirez, Luis E. ; Rodriguez-Diaz, Roberto ; Durán, Adriana S. ; Losso, Marcelo H. ; Salomón, Horacio ; Gómez-Carrillo, Manuel ; Pampuro, Sandra ; Harris, D. Robert ; Duarte, Geraldo ; De Souza, Ricardo S. ; Read, Jennifer S.
creatorcontribSoto-Ramirez, Luis E. ; Rodriguez-Diaz, Roberto ; Durán, Adriana S. ; Losso, Marcelo H. ; Salomón, Horacio ; Gómez-Carrillo, Manuel ; Pampuro, Sandra ; Harris, D. Robert ; Duarte, Geraldo ; De Souza, Ricardo S. ; Read, Jennifer S. ; NISDI Perinatal Study Group
descriptionResistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6–12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6–12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6–12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7–25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (>15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
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subjectAIDS/HIV ; Anti-HIV Agents - therapeutic use ; Biological and medical sciences ; Care and treatment ; Caribbean Region - epidemiology ; Clinical Studies ; Clinical Trials ; CLINICAL TRIALS/CLINICAL STUDIES ; Diagnosis ; Drug resistance in microorganisms ; Drug Resistance, Multiple, Viral - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Gene mutations ; Genetic aspects ; Genotype ; Health aspects ; HIV infection ; HIV infection in pregnancy ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV-1 - drug effects ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious diseases ; Latin America - epidemiology ; Leukocytes, Mononuclear - virology ; Medical sciences ; Microbiology ; Miscellaneous ; Mutation ; Patient Selection ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - virology ; Prospective Studies ; Retrovirus ; Risk factors ; RNA, Viral - blood ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virology
ispartofAIDS research and human retroviruses, 2008, Vol.24 (6), p.797-804
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1Rodriguez-Diaz, Roberto
2Durán, Adriana S.
3Losso, Marcelo H.
4Salomón, Horacio
5Gómez-Carrillo, Manuel
6Pampuro, Sandra
7Harris, D. Robert
8Duarte, Geraldo
9De Souza, Ricardo S.
10Read, Jennifer S.
11NISDI Perinatal Study Group
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0Antiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
1AIDS research and human retroviruses
addtitleAIDS Res Hum Retroviruses
descriptionResistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6–12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6–12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6–12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7–25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (>15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
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2Biological and medical sciences
3Care and treatment
4Caribbean Region - epidemiology
5Clinical Studies
6Clinical Trials
7CLINICAL TRIALS/CLINICAL STUDIES
8Diagnosis
9Drug resistance in microorganisms
10Drug Resistance, Multiple, Viral - genetics
11Female
12Fundamental and applied biological sciences. Psychology
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17HIV infection
18HIV infection in pregnancy
19HIV Infections - drug therapy
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21HIV Infections - transmission
22HIV-1 - drug effects
23HIV-1 - genetics
24Human immunodeficiency virus 1
25Human viral diseases
26Humans
27Infectious Disease Transmission, Vertical - prevention & control
28Infectious diseases
29Latin America - epidemiology
30Leukocytes, Mononuclear - virology
31Medical sciences
32Microbiology
33Miscellaneous
34Mutation
35Patient Selection
36Pregnancy
37Pregnancy Complications, Infectious - drug therapy
38Pregnancy Complications, Infectious - epidemiology
39Pregnancy Complications, Infectious - virology
40Prospective Studies
41Retrovirus
42Risk factors
43RNA, Viral - blood
44Viral diseases
45Viral diseases of the lymphoid tissue and the blood. Aids
46Viral Load
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titleAntiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
authorSoto-Ramirez, Luis E. ; Rodriguez-Diaz, Roberto ; Durán, Adriana S. ; Losso, Marcelo H. ; Salomón, Horacio ; Gómez-Carrillo, Manuel ; Pampuro, Sandra ; Harris, D. Robert ; Duarte, Geraldo ; De Souza, Ricardo S. ; Read, Jennifer S.
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4Caribbean Region - epidemiology
5Clinical Studies
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10Drug Resistance, Multiple, Viral - genetics
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14Genetic aspects
15Genotype
16Health aspects
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atitleAntiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
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abstractResistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6–12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6–12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6–12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7–25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (>15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
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pmid18507526
doi10.1089/aid.2007.0246
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