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Antiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs

Resistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected... Full description

Journal Title: AIDS research and human retroviruses 2008, Vol.24 (6), p.797-804
Main Author: SOTO-RAMIREZ, Luis E
Other Authors: RODRIGUEZ-DIAZ, Roberto , READ, Jennifer S , DURAN, Adriana S , LOSSO, Marcelo H , SALOMON, Horacio , GOMEZ-CARRILLO, Manuel , PAMPURO, Sandra , HARRIS, D. Robert , DUARTE, Geraldo , DE SOUZA, Ricardo S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Larchmont, NY: Liebert
ID: ISSN: 0889-2229
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2928544
title: Antiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
format: Article
creator:
  • SOTO-RAMIREZ, Luis E
  • RODRIGUEZ-DIAZ, Roberto
  • READ, Jennifer S
  • DURAN, Adriana S
  • LOSSO, Marcelo H
  • SALOMON, Horacio
  • GOMEZ-CARRILLO, Manuel
  • PAMPURO, Sandra
  • HARRIS, D. Robert
  • DUARTE, Geraldo
  • DE SOUZA, Ricardo S
subjects:
  • AIDS/HIV
  • Anti-HIV Agents - therapeutic use
  • Biological and medical sciences
  • Care and treatment
  • Caribbean Region - epidemiology
  • Clinical Studies
  • Clinical Trials
  • Diagnosis
  • Drug resistance in microorganisms
  • Drug Resistance, Multiple, Viral - genetics
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Gene mutations
  • Genetic aspects
  • Genotype
  • Health aspects
  • HIV infection
  • HIV infection in pregnancy
  • HIV Infections - drug therapy
  • HIV Infections - epidemiology
  • HIV Infections - transmission
  • HIV-1 - drug effects
  • HIV-1 - genetics
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Infectious Disease Transmission, Vertical - prevention & control
  • Infectious diseases
  • Latin America - epidemiology
  • Leukocytes, Mononuclear - virology
  • Medical sciences
  • Microbiology
  • Miscellaneous
  • Mutation
  • Patient Selection
  • Pregnancy
  • Pregnancy Complications, Infectious - drug therapy
  • Pregnancy Complications, Infectious - epidemiology
  • Pregnancy Complications, Infectious - virology
  • Prospective Studies
  • Retrovirus
  • Risk factors
  • RNA, Viral - blood
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Viral Load
  • Virology
ispartof: AIDS research and human retroviruses, 2008, Vol.24 (6), p.797-804
description: Resistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6-12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6-12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6-12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7-25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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titleAntiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
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creatorSOTO-RAMIREZ, Luis E ; RODRIGUEZ-DIAZ, Roberto ; READ, Jennifer S ; DURAN, Adriana S ; LOSSO, Marcelo H ; SALOMON, Horacio ; GOMEZ-CARRILLO, Manuel ; PAMPURO, Sandra ; HARRIS, D. Robert ; DUARTE, Geraldo ; DE SOUZA, Ricardo S
creatorcontribSOTO-RAMIREZ, Luis E ; RODRIGUEZ-DIAZ, Roberto ; READ, Jennifer S ; DURAN, Adriana S ; LOSSO, Marcelo H ; SALOMON, Horacio ; GOMEZ-CARRILLO, Manuel ; PAMPURO, Sandra ; HARRIS, D. Robert ; DUARTE, Geraldo ; DE SOUZA, Ricardo S ; NISDI Perinatal Study Group
descriptionResistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6-12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6-12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6-12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7-25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
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subjectAIDS/HIV ; Anti-HIV Agents - therapeutic use ; Biological and medical sciences ; Care and treatment ; Caribbean Region - epidemiology ; Clinical Studies ; Clinical Trials ; Diagnosis ; Drug resistance in microorganisms ; Drug Resistance, Multiple, Viral - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Gene mutations ; Genetic aspects ; Genotype ; Health aspects ; HIV infection ; HIV infection in pregnancy ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV-1 - drug effects ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious diseases ; Latin America - epidemiology ; Leukocytes, Mononuclear - virology ; Medical sciences ; Microbiology ; Miscellaneous ; Mutation ; Patient Selection ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - virology ; Prospective Studies ; Retrovirus ; Risk factors ; RNA, Viral - blood ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virology
ispartofAIDS research and human retroviruses, 2008, Vol.24 (6), p.797-804
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1RODRIGUEZ-DIAZ, Roberto
2READ, Jennifer S
3DURAN, Adriana S
4LOSSO, Marcelo H
5SALOMON, Horacio
6GOMEZ-CARRILLO, Manuel
7PAMPURO, Sandra
8HARRIS, D. Robert
9DUARTE, Geraldo
10DE SOUZA, Ricardo S
11NISDI Perinatal Study Group
title
0Antiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
1AIDS research and human retroviruses
addtitleAIDS Res Hum Retroviruses
descriptionResistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6-12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6-12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6-12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7-25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
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0AIDS/HIV
1Anti-HIV Agents - therapeutic use
2Biological and medical sciences
3Care and treatment
4Caribbean Region - epidemiology
5Clinical Studies
6Clinical Trials
7Diagnosis
8Drug resistance in microorganisms
9Drug Resistance, Multiple, Viral - genetics
10Female
11Fundamental and applied biological sciences. Psychology
12Gene mutations
13Genetic aspects
14Genotype
15Health aspects
16HIV infection
17HIV infection in pregnancy
18HIV Infections - drug therapy
19HIV Infections - epidemiology
20HIV Infections - transmission
21HIV-1 - drug effects
22HIV-1 - genetics
23Human immunodeficiency virus 1
24Human viral diseases
25Humans
26Infectious Disease Transmission, Vertical - prevention & control
27Infectious diseases
28Latin America - epidemiology
29Leukocytes, Mononuclear - virology
30Medical sciences
31Microbiology
32Miscellaneous
33Mutation
34Patient Selection
35Pregnancy
36Pregnancy Complications, Infectious - drug therapy
37Pregnancy Complications, Infectious - epidemiology
38Pregnancy Complications, Infectious - virology
39Prospective Studies
40Retrovirus
41Risk factors
42RNA, Viral - blood
43Viral diseases
44Viral diseases of the lymphoid tissue and the blood. Aids
45Viral Load
46Virology
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titleAntiretroviral Resistance among HIV Type 1-Infected Women First Exposed to Antiretrovirals during Pregnancy: Plasma versus PBMCs
authorSOTO-RAMIREZ, Luis E ; RODRIGUEZ-DIAZ, Roberto ; READ, Jennifer S ; DURAN, Adriana S ; LOSSO, Marcelo H ; SALOMON, Horacio ; GOMEZ-CARRILLO, Manuel ; PAMPURO, Sandra ; HARRIS, D. Robert ; DUARTE, Geraldo ; DE SOUZA, Ricardo S
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1Anti-HIV Agents - therapeutic use
2Biological and medical sciences
3Care and treatment
4Caribbean Region - epidemiology
5Clinical Studies
6Clinical Trials
7Diagnosis
8Drug resistance in microorganisms
9Drug Resistance, Multiple, Viral - genetics
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11Fundamental and applied biological sciences. Psychology
12Gene mutations
13Genetic aspects
14Genotype
15Health aspects
16HIV infection
17HIV infection in pregnancy
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19HIV Infections - epidemiology
20HIV Infections - transmission
21HIV-1 - drug effects
22HIV-1 - genetics
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abstractResistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs in peripheral blood mononuclear cells (PMBCs). The study population was composed of HIV-1-infected women enrolled in a prospective cohort study in Latin America and the Caribbean (NISDI Perinatal Study) as of March 1, 2005, who were diagnosed with HIV-1 infection during the current pregnancy, who received ARVs during pregnancy for prevention of mother-to-child transmission of HIV-1, and who were followed through at least the 6-12 week postpartum visit. Plasma samples collected at enrollment during pregnancy and at 6-12 weeks postpartum were assayed for RAMs. Plasma results were compared to previously described PBMC results from the same study population. Of 819 enrolled subjects, 197 met the eligibility criteria. Nucleic acid amplification was accomplished in 123 plasma samples at enrollment or 6-12 weeks postpartum, and RAMs were detected in 22 (17.9%; 95%CI: 11.7-25.9%). Previous analyses had demonstrated detection of RAMs in PBMCs in 19 (16.1%). There was high concordance between RAMs detected in plasma and PBMC samples, with only eight discordant pairs. The prevalence of RAMs among these pregnant, HIV-1-infected women is high (15%). Rates of detection of RAMs in plasma and PBMC samples were similar.
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pubLiebert
pmid18507526
doi10.1089/aid.2007.0246
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