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Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study

Background We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD). Methods The Atherosclerosis Risk in Communities Study assessed risk factors and levels of serum Mg in a cohort of 45- to 64-year-old subjects in 1987-1989 (n = 14,232). After an aver... Full description

Journal Title: The American heart journal 2010, Vol.160 (3), p.464-470
Main Author: Peacock, James M., PhD
Other Authors: Ohira, Tetsuya, MD , Post, Wendy, MD , Sotoodehnia, Nona, MD , Rosamond, Wayne, PhD , Folsom, Aaron R., MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
Alcohol use
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Article
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - blood
Atherosclerosis - epidemiology
Biological and medical sciences
Blood and lymphatic vessels
Cardiac arrest
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
cohort study
Death, Sudden, Cardiac - epidemiology
Diabetes
Effect Modifier, Epidemiologic
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Female
Glucose
Heart
Heart attacks
Heart rate
Humans
Hypertension
Intensive care medicine
Magnesium
Magnesium - blood
Male
Medical sciences
Middle Aged
Population
Proportional Hazards Models
Public health
Questionnaires
Risk Factors
Shipments
Smoking
Studies
sudden cardiac death
Triglycerides
Universities and colleges
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Mosby, Inc
ID: ISSN: 0002-8703
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2939007
title: Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study
format: Article
creator:
  • Peacock, James M., PhD
  • Ohira, Tetsuya, MD
  • Post, Wendy, MD
  • Sotoodehnia, Nona, MD
  • Rosamond, Wayne, PhD
  • Folsom, Aaron R., MD
subjects:
  • Abridged Index Medicus
  • Alcohol use
  • Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
  • Article
  • Atherosclerosis
  • Atherosclerosis (general aspects, experimental research)
  • Atherosclerosis - blood
  • Atherosclerosis - epidemiology
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiac arrest
  • Cardiology. Vascular system
  • Cardiovascular
  • Cardiovascular disease
  • cohort study
  • Death, Sudden, Cardiac - epidemiology
  • Diabetes
  • Effect Modifier, Epidemiologic
  • Emergency and intensive care: neonates and children. Prematurity. Sudden death
  • Female
  • Glucose
  • Heart
  • Heart attacks
  • Heart rate
  • Humans
  • Hypertension
  • Intensive care medicine
  • Magnesium
  • Magnesium - blood
  • Male
  • Medical sciences
  • Middle Aged
  • Population
  • Proportional Hazards Models
  • Public health
  • Questionnaires
  • Risk Factors
  • Shipments
  • Smoking
  • Studies
  • sudden cardiac death
  • Triglycerides
  • Universities and colleges
ispartof: The American heart journal, 2010, Vol.160 (3), p.464-470
description: Background We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD). Methods The Atherosclerosis Risk in Communities Study assessed risk factors and levels of serum Mg in a cohort of 45- to 64-year-old subjects in 1987-1989 (n = 14,232). After an average of 12 years of follow-up, we observed 264 cases of SCD, as determined by physician review of all suspected cases. We used proportional hazards regression to evaluate the association of serum Mg with risk of SCD. Results Individuals in the highest quartile of serum Mg were at significantly lower risk of SCD in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI 0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted model. Conclusions This study suggests that low levels of serum Mg may be an important predictor of SCD. Further research into the effectiveness of Mg supplementation for those considered to be at high risk for SCD is warranted.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-8703
fulltext: fulltext
issn:
  • 0002-8703
  • 1097-6744
url: Link


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titleSerum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study
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creatorPeacock, James M., PhD ; Ohira, Tetsuya, MD ; Post, Wendy, MD ; Sotoodehnia, Nona, MD ; Rosamond, Wayne, PhD ; Folsom, Aaron R., MD
creatorcontribPeacock, James M., PhD ; Ohira, Tetsuya, MD ; Post, Wendy, MD ; Sotoodehnia, Nona, MD ; Rosamond, Wayne, PhD ; Folsom, Aaron R., MD
descriptionBackground We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD). Methods The Atherosclerosis Risk in Communities Study assessed risk factors and levels of serum Mg in a cohort of 45- to 64-year-old subjects in 1987-1989 (n = 14,232). After an average of 12 years of follow-up, we observed 264 cases of SCD, as determined by physician review of all suspected cases. We used proportional hazards regression to evaluate the association of serum Mg with risk of SCD. Results Individuals in the highest quartile of serum Mg were at significantly lower risk of SCD in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI 0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted model. Conclusions This study suggests that low levels of serum Mg may be an important predictor of SCD. Further research into the effectiveness of Mg supplementation for those considered to be at high risk for SCD is warranted.
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subjectAbridged Index Medicus ; Alcohol use ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Article ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - blood ; Atherosclerosis - epidemiology ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiac arrest ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; cohort study ; Death, Sudden, Cardiac - epidemiology ; Diabetes ; Effect Modifier, Epidemiologic ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Glucose ; Heart ; Heart attacks ; Heart rate ; Humans ; Hypertension ; Intensive care medicine ; Magnesium ; Magnesium - blood ; Male ; Medical sciences ; Middle Aged ; Population ; Proportional Hazards Models ; Public health ; Questionnaires ; Risk Factors ; Shipments ; Smoking ; Studies ; sudden cardiac death ; Triglycerides ; Universities and colleges
ispartofThe American heart journal, 2010, Vol.160 (3), p.464-470
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4Rosamond, Wayne, PhD
5Folsom, Aaron R., MD
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descriptionBackground We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD). Methods The Atherosclerosis Risk in Communities Study assessed risk factors and levels of serum Mg in a cohort of 45- to 64-year-old subjects in 1987-1989 (n = 14,232). After an average of 12 years of follow-up, we observed 264 cases of SCD, as determined by physician review of all suspected cases. We used proportional hazards regression to evaluate the association of serum Mg with risk of SCD. Results Individuals in the highest quartile of serum Mg were at significantly lower risk of SCD in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI 0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted model. Conclusions This study suggests that low levels of serum Mg may be an important predictor of SCD. Further research into the effectiveness of Mg supplementation for those considered to be at high risk for SCD is warranted.
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1Alcohol use
2Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
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5Atherosclerosis (general aspects, experimental research)
6Atherosclerosis - blood
7Atherosclerosis - epidemiology
8Biological and medical sciences
9Blood and lymphatic vessels
10Cardiac arrest
11Cardiology. Vascular system
12Cardiovascular
13Cardiovascular disease
14cohort study
15Death, Sudden, Cardiac - epidemiology
16Diabetes
17Effect Modifier, Epidemiologic
18Emergency and intensive care: neonates and children. Prematurity. Sudden death
19Female
20Glucose
21Heart
22Heart attacks
23Heart rate
24Humans
25Hypertension
26Intensive care medicine
27Magnesium
28Magnesium - blood
29Male
30Medical sciences
31Middle Aged
32Population
33Proportional Hazards Models
34Public health
35Questionnaires
36Risk Factors
37Shipments
38Smoking
39Studies
40sudden cardiac death
41Triglycerides
42Universities and colleges
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authorPeacock, James M., PhD ; Ohira, Tetsuya, MD ; Post, Wendy, MD ; Sotoodehnia, Nona, MD ; Rosamond, Wayne, PhD ; Folsom, Aaron R., MD
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2Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
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5Atherosclerosis (general aspects, experimental research)
6Atherosclerosis - blood
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1Ohira, Tetsuya, MD
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abstractBackground We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD). Methods The Atherosclerosis Risk in Communities Study assessed risk factors and levels of serum Mg in a cohort of 45- to 64-year-old subjects in 1987-1989 (n = 14,232). After an average of 12 years of follow-up, we observed 264 cases of SCD, as determined by physician review of all suspected cases. We used proportional hazards regression to evaluate the association of serum Mg with risk of SCD. Results Individuals in the highest quartile of serum Mg were at significantly lower risk of SCD in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI 0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted model. Conclusions This study suggests that low levels of serum Mg may be an important predictor of SCD. Further research into the effectiveness of Mg supplementation for those considered to be at high risk for SCD is warranted.
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pmid20826254
doi10.1016/j.ahj.2010.06.012
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