schliessen

Filtern

 

Bibliotheken

Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda

To assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted... Full description

Journal Title: AIDS (London) 2010, Vol.24 (12), p.1937-1944
Main Author: POLIS, Chelsea B
Other Authors: WAWER, Maria J , KIWANUKA, Noah , LAEYENDECKER, Oliver , KAGAAYI, Joseph , LUTALO, Tom , NALUGODA, Fred , KIGOZI, Godfrey , SERWADDA, David , GRAY, Ronald H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2939866
title: Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
format: Article
creator:
  • POLIS, Chelsea B
  • WAWER, Maria J
  • KIWANUKA, Noah
  • LAEYENDECKER, Oliver
  • KAGAAYI, Joseph
  • LUTALO, Tom
  • NALUGODA, Fred
  • KIGOZI, Godfrey
  • SERWADDA, David
  • GRAY, Ronald H
subjects:
  • Adolescent
  • Adult
  • Age Distribution
  • Article
  • Biological and medical sciences
  • Confidence Intervals
  • Contraceptives, Oral, Hormonal - adverse effects
  • Disease Progression
  • family planning
  • Female
  • HIV progression
  • HIV Seropositivity - complications
  • HIV Seropositivity - drug therapy
  • HIV Seropositivity - mortality
  • HIV-1
  • hormonal contraception
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Infectious diseases
  • Medical sciences
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • survival analysis
  • Uganda
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Young Adult
ispartof: AIDS (London), 2010, Vol.24 (12), p.1937-1944
description: To assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.3609843
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2939866
sourceformatXML
sourcesystemPC
sourcerecordid755143187
originalsourceidFETCH-LOGICAL-14501-a72c3027d6a6f0e3495839118ebe3af5c69b09e79b9ae1c77df83fa82ebed1470
addsrcrecordideNp9Uktv1DAQjhCILoV_gFAuiAspfsRxzAGpKoWtVAmBKFdrYo-3hiQOdnYl_j1Odym0By5-6HvMjL4piueUnFCi5JvPp-9PSEcoR85azrt8sgfFitaSV0JI-rBYEdaoSnFJjoonKX0nhAjSto-LI5YfjNN6VeC5c2jmMrjyOsQhjNCXJoxzBIPT7HdYbhOWYSzXF9_KKYZNxJR8_vuxdDhAjzdIwhiybIdxxpgW8Av8AP-6vNrAaOFp8chBn_DZ4T4urj6cfz1bV5efPl6cnV5WtBaEViCZ4YRJ20DjCPJaiZYrSlvskIMTplEdUShVpwCpkdK6ljtoWcZtHpwcF-_2vtO2G9AaXAbp9RT9APGXDuD1XWT013oTdpoprtqmyQbrvUGYcAQf8Y7WjjjrYDVrpM71FEgHhrWGQCOsIwosCMsllwJttnp16CWGn1tMsx58Mtj3MGLYJi2FoDWn7dJ1vWeaGFKK6G6LUqKXrHXOWt_POste_DvsrehPuJnw8kCAZKB3EUbj018ez8tAxTL023v1jZ9h9jdr4Pv_d_Ebjf7F1g
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid755143187
display
typearticle
titleEffect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
creatorPOLIS, Chelsea B ; WAWER, Maria J ; KIWANUKA, Noah ; LAEYENDECKER, Oliver ; KAGAAYI, Joseph ; LUTALO, Tom ; NALUGODA, Fred ; KIGOZI, Godfrey ; SERWADDA, David ; GRAY, Ronald H
creatorcontribPOLIS, Chelsea B ; WAWER, Maria J ; KIWANUKA, Noah ; LAEYENDECKER, Oliver ; KAGAAYI, Joseph ; LUTALO, Tom ; NALUGODA, Fred ; KIGOZI, Godfrey ; SERWADDA, David ; GRAY, Ronald H
descriptionTo assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
identifier
0ISSN: 0269-9370
1EISSN: 1473-5571
2DOI: 10.1097/QAD.0b013e32833b3282
3PMID: 20502314
languageeng
publisherHagerstown, MD: Lippincott Williams & Wilkins
subjectAdolescent ; Adult ; Age Distribution ; Article ; Biological and medical sciences ; Confidence Intervals ; Contraceptives, Oral, Hormonal - adverse effects ; Disease Progression ; family planning ; Female ; HIV progression ; HIV Seropositivity - complications ; HIV Seropositivity - drug therapy ; HIV Seropositivity - mortality ; HIV-1 ; hormonal contraception ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Medical sciences ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; survival analysis ; Uganda ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult
ispartofAIDS (London), 2010, Vol.24 (12), p.1937-1944
rights2015 INIST-CNRS
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-14501-a72c3027d6a6f0e3495839118ebe3af5c69b09e79b9ae1c77df83fa82ebed1470
citesFETCH-LOGICAL-14501-a72c3027d6a6f0e3495839118ebe3af5c69b09e79b9ae1c77df83fa82ebed1470
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23088156$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20502314$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0POLIS, Chelsea B
1WAWER, Maria J
2KIWANUKA, Noah
3LAEYENDECKER, Oliver
4KAGAAYI, Joseph
5LUTALO, Tom
6NALUGODA, Fred
7KIGOZI, Godfrey
8SERWADDA, David
9GRAY, Ronald H
title
0Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
1AIDS (London)
addtitleAIDS
descriptionTo assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
subject
0Adolescent
1Adult
2Age Distribution
3Article
4Biological and medical sciences
5Confidence Intervals
6Contraceptives, Oral, Hormonal - adverse effects
7Disease Progression
8family planning
9Female
10HIV progression
11HIV Seropositivity - complications
12HIV Seropositivity - drug therapy
13HIV Seropositivity - mortality
14HIV-1
15hormonal contraception
16Human immunodeficiency virus
17Human viral diseases
18Humans
19Immunodeficiencies
20Immunodeficiencies. Immunoglobulinopathies
21Immunopathology
22Infectious diseases
23Medical sciences
24Proportional Hazards Models
25Retrospective Studies
26Risk Factors
27survival analysis
28Uganda
29Viral diseases
30Viral diseases of the lymphoid tissue and the blood. Aids
31Young Adult
issn
00269-9370
11473-5571
fulltextfalse
rsrctypearticle
creationdate2010
recordtypearticle
recordideNp9Uktv1DAQjhCILoV_gFAuiAspfsRxzAGpKoWtVAmBKFdrYo-3hiQOdnYl_j1Odym0By5-6HvMjL4piueUnFCi5JvPp-9PSEcoR85azrt8sgfFitaSV0JI-rBYEdaoSnFJjoonKX0nhAjSto-LI5YfjNN6VeC5c2jmMrjyOsQhjNCXJoxzBIPT7HdYbhOWYSzXF9_KKYZNxJR8_vuxdDhAjzdIwhiybIdxxpgW8Av8AP-6vNrAaOFp8chBn_DZ4T4urj6cfz1bV5efPl6cnV5WtBaEViCZ4YRJ20DjCPJaiZYrSlvskIMTplEdUShVpwCpkdK6ljtoWcZtHpwcF-_2vtO2G9AaXAbp9RT9APGXDuD1XWT013oTdpoprtqmyQbrvUGYcAQf8Y7WjjjrYDVrpM71FEgHhrWGQCOsIwosCMsllwJttnp16CWGn1tMsx58Mtj3MGLYJi2FoDWn7dJ1vWeaGFKK6G6LUqKXrHXOWt_POste_DvsrehPuJnw8kCAZKB3EUbj018ez8tAxTL023v1jZ9h9jdr4Pv_d_Ebjf7F1g
startdate2010
enddate2010
creator
0POLIS, Chelsea B
1WAWER, Maria J
2KIWANUKA, Noah
3LAEYENDECKER, Oliver
4KAGAAYI, Joseph
5LUTALO, Tom
6NALUGODA, Fred
7KIGOZI, Godfrey
8SERWADDA, David
9GRAY, Ronald H
generalLippincott Williams & Wilkins
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97T5
107U9
11H94
12BOBZL
13CLFQK
145PM
sort
creationdate2010
titleEffect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
authorPOLIS, Chelsea B ; WAWER, Maria J ; KIWANUKA, Noah ; LAEYENDECKER, Oliver ; KAGAAYI, Joseph ; LUTALO, Tom ; NALUGODA, Fred ; KIGOZI, Godfrey ; SERWADDA, David ; GRAY, Ronald H
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-14501-a72c3027d6a6f0e3495839118ebe3af5c69b09e79b9ae1c77df83fa82ebed1470
rsrctypearticles
prefilterarticles
languageeng
creationdate2010
topic
0Adolescent
1Adult
2Age Distribution
3Article
4Biological and medical sciences
5Confidence Intervals
6Contraceptives, Oral, Hormonal - adverse effects
7Disease Progression
8family planning
9Female
10HIV progression
11HIV Seropositivity - complications
12HIV Seropositivity - drug therapy
13HIV Seropositivity - mortality
14HIV-1
15hormonal contraception
16Human immunodeficiency virus
17Human viral diseases
18Humans
19Immunodeficiencies
20Immunodeficiencies. Immunoglobulinopathies
21Immunopathology
22Infectious diseases
23Medical sciences
24Proportional Hazards Models
25Retrospective Studies
26Risk Factors
27survival analysis
28Uganda
29Viral diseases
30Viral diseases of the lymphoid tissue and the blood. Aids
31Young Adult
toplevelpeer_reviewed
creatorcontrib
0POLIS, Chelsea B
1WAWER, Maria J
2KIWANUKA, Noah
3LAEYENDECKER, Oliver
4KAGAAYI, Joseph
5LUTALO, Tom
6NALUGODA, Fred
7KIGOZI, Godfrey
8SERWADDA, David
9GRAY, Ronald H
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Immunology Abstracts
9Virology and AIDS Abstracts
10AIDS and Cancer Research Abstracts
11OpenAIRE (Open Access)
12OpenAIRE
13PubMed Central (Full Participant titles)
jtitleAIDS (London)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0POLIS, Chelsea B
1WAWER, Maria J
2KIWANUKA, Noah
3LAEYENDECKER, Oliver
4KAGAAYI, Joseph
5LUTALO, Tom
6NALUGODA, Fred
7KIGOZI, Godfrey
8SERWADDA, David
9GRAY, Ronald H
formatjournal
genrearticle
ristypeJOUR
atitleEffect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
jtitleAIDS (London)
addtitleAIDS
date2010
risdate2010
volume24
issue12
spage1937
epage1944
pages1937-1944
issn0269-9370
eissn1473-5571
abstractTo assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid20502314
doi10.1097/QAD.0b013e32833b3282
oafree_for_read