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Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda

To assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted... Full description

Journal Title: AIDS (London) 2010, Vol.24 (12), p.1937-1944
Main Author: POLIS, Chelsea B
Other Authors: WAWER, Maria J , KIWANUKA, Noah , LAEYENDECKER, Oliver , KAGAAYI, Joseph , LUTALO, Tom , NALUGODA, Fred , KIGOZI, Godfrey , SERWADDA, David , GRAY, Ronald H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adolescent
Adult
Age Distribution
Article
Biological and medical sciences
Confidence Intervals
Contraceptives, Oral, Hormonal - adverse effects
Disease Progression
family planning
Female
HIV progression
HIV Seropositivity - complications
HIV Seropositivity - drug therapy
HIV Seropositivity - mortality
HIV-1
hormonal contraception
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Medical sciences
Proportional Hazards Models
Retrospective Studies
Risk Factors
survival analysis
Uganda
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Young Adult
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
Zum Text:
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title: Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
format: Article
creator:
  • POLIS, Chelsea B
  • WAWER, Maria J
  • KIWANUKA, Noah
  • LAEYENDECKER, Oliver
  • KAGAAYI, Joseph
  • LUTALO, Tom
  • NALUGODA, Fred
  • KIGOZI, Godfrey
  • SERWADDA, David
  • GRAY, Ronald H
subjects:
  • Adolescent
  • Adult
  • Age Distribution
  • Article
  • Biological and medical sciences
  • Confidence Intervals
  • Contraceptives, Oral, Hormonal - adverse effects
  • Disease Progression
  • family planning
  • Female
  • HIV progression
  • HIV Seropositivity - complications
  • HIV Seropositivity - drug therapy
  • HIV Seropositivity - mortality
  • HIV-1
  • hormonal contraception
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Infectious diseases
  • Medical sciences
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • survival analysis
  • Uganda
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Young Adult
ispartof: AIDS (London), 2010, Vol.24 (12), p.1937-1944
description: To assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleEffect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
creatorPOLIS, Chelsea B ; WAWER, Maria J ; KIWANUKA, Noah ; LAEYENDECKER, Oliver ; KAGAAYI, Joseph ; LUTALO, Tom ; NALUGODA, Fred ; KIGOZI, Godfrey ; SERWADDA, David ; GRAY, Ronald H
creatorcontribPOLIS, Chelsea B ; WAWER, Maria J ; KIWANUKA, Noah ; LAEYENDECKER, Oliver ; KAGAAYI, Joseph ; LUTALO, Tom ; NALUGODA, Fred ; KIGOZI, Godfrey ; SERWADDA, David ; GRAY, Ronald H
descriptionTo assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
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subjectAdolescent ; Adult ; Age Distribution ; Article ; Biological and medical sciences ; Confidence Intervals ; Contraceptives, Oral, Hormonal - adverse effects ; Disease Progression ; family planning ; Female ; HIV progression ; HIV Seropositivity - complications ; HIV Seropositivity - drug therapy ; HIV Seropositivity - mortality ; HIV-1 ; hormonal contraception ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Medical sciences ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; survival analysis ; Uganda ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult
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descriptionTo assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
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4Biological and medical sciences
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6Contraceptives, Oral, Hormonal - adverse effects
7Disease Progression
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10HIV progression
11HIV Seropositivity - complications
12HIV Seropositivity - drug therapy
13HIV Seropositivity - mortality
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25Retrospective Studies
26Risk Factors
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titleEffect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
authorPOLIS, Chelsea B ; WAWER, Maria J ; KIWANUKA, Noah ; LAEYENDECKER, Oliver ; KAGAAYI, Joseph ; LUTALO, Tom ; NALUGODA, Fred ; KIGOZI, Godfrey ; SERWADDA, David ; GRAY, Ronald H
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6Contraceptives, Oral, Hormonal - adverse effects
7Disease Progression
8family planning
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10HIV progression
11HIV Seropositivity - complications
12HIV Seropositivity - drug therapy
13HIV Seropositivity - mortality
14HIV-1
15hormonal contraception
16Human immunodeficiency virus
17Human viral diseases
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21Immunopathology
22Infectious diseases
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25Retrospective Studies
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issn0269-9370
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abstractTo assess the association between hormonal contraceptive use and HIV progression. A retrospective analysis of 625 female HIV seroconverters from a Ugandan cohort study. Multivariate Cox regression analyses incorporating time-varying hormonal contraceptive exposure were used to estimate the adjusted hazard ratios of death, and a composite outcome of AIDS or death, associated with hormonal contraceptive use. Sensitivity analyses included lagging hormonal contraceptive exposure, varying comparison groups, and separately assessing effects of oral and injectable contraceptives. A total of 27.5% of women reported ever using hormonal contraception. Of 625 women, 104 (16.6%) died and 291 (46.6%) progressed to AIDS or death during observation. Time-varying hormonal contraceptive use was not associated with an increased hazard of death as compared with nonuse of hormonal contraception (adjusted hazard ratio 0.76, 95% confidence interval 0.41-1.39, P = 0.37), and was associated with a significantly reduced hazard of progression to AIDS or death (adjusted hazard ratio 0.70, 95% confidence interval 0.50-0.97, P = 0.03). None of the sensitivity analyses suggested an adverse effect of hormonal contraception on HIV progression. Hormonal contraceptive use was not associated with faster progression to death, and was associated with a reduced hazard of progression to the composite outcome of AIDS or death.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid20502314
doi10.1097/QAD.0b013e32833b3282
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