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Changes in the Distribution of HIV Type 1 Subtypes D and A in Rakai District, Uganda Between 1994 and 2002

HIV-1 subtype D (HIV-1D) progresses to disease faster and has lower transmissibility than subtype A (HIV-1A). We examined whether these differences could lead to a population level change in the distribution of these subtypes over time. HIV-1 viral RNA was extracted from stored serum samples from HI... Full description

Journal Title: AIDS research and human retroviruses 2010, Vol.26 (10), p.187-1091
Main Author: Conroy, Samantha A.
Other Authors: Laeyendecker, Oliver , Redd, Andrew D. , Collinson-Streng, Aleisha , Kong, Xiangrong , Makumbi, Fredrick , Lutalo, Tom , Sewankambo, Nelson , Kiwanuka, Noah , Gray, Ronald H. , Wawer, Maria J. , Serwadda, David , Quinn, Thomas C.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New Rochelle, NY: Mary Ann Liebert, Inc
ID: ISSN: 0889-2229
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title: Changes in the Distribution of HIV Type 1 Subtypes D and A in Rakai District, Uganda Between 1994 and 2002
format: Article
creator:
  • Conroy, Samantha A.
  • Laeyendecker, Oliver
  • Redd, Andrew D.
  • Collinson-Streng, Aleisha
  • Kong, Xiangrong
  • Makumbi, Fredrick
  • Lutalo, Tom
  • Sewankambo, Nelson
  • Kiwanuka, Noah
  • Gray, Ronald H.
  • Wawer, Maria J.
  • Serwadda, David
  • Quinn, Thomas C.
subjects:
  • Adolescent
  • Adult
  • AIDS/HIV
  • Biological and medical sciences
  • Cohort Studies
  • Development and progression
  • Diagnosis
  • Disease transmission
  • Epidemiology
  • Fundamental and applied biological sciences. Psychology
  • gag Gene Products, Human Immunodeficiency Virus - genetics
  • gag Gene Products, Human Immunodeficiency Virus - metabolism
  • Genetic aspects
  • HIV Envelope Protein gp41 - genetics
  • HIV Envelope Protein gp41 - metabolism
  • HIV infection
  • HIV Infections - epidemiology
  • HIV Infections - genetics
  • HIV Infections - transmission
  • HIV testing
  • HIV-1 - classification
  • HIV-1 - genetics
  • HIV-1 - pathogenicity
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Infectious diseases
  • Medical sciences
  • Microbiology
  • Middle Aged
  • Miscellaneous
  • Molecular Sequence Data
  • Recombination, Genetic
  • Retrovirus
  • RNA Viruses - pathogenicity
  • Rural Population
  • Sequence Analysis, DNA
  • Uganda - epidemiology
  • Viral diseases
  • Virology
  • virus diseases
  • Young Adult
ispartof: AIDS research and human retroviruses, 2010, Vol.26 (10), p.187-1091
description: HIV-1 subtype D (HIV-1D) progresses to disease faster and has lower transmissibility than subtype A (HIV-1A). We examined whether these differences could lead to a population level change in the distribution of these subtypes over time. HIV-1 viral RNA was extracted from stored serum samples from HIV-positive subjects participating in a population-based cohort study in Rakai, Uganda in 1994 and 2002. Portions of the viral proteins gag and gp41 were sequenced and subtyped. HIV-1 subtype assignments were generated for 773 subjects in 1994 and 812 subjects in 2002. The change in subtype distribution of the population as a whole as well as quartile age groups were examined for significant changes using a linear model. There was a significant decrease in the proportion of subjects infected with HIV-1D from 70.2% to 62.4% and a significant increase in subjects infected with HIV-1A from 16.7% to 23.3% over the 8-year period ( p  = 0.005). The most marked changes in proportion of HIV-1D and A were seen in the younger individuals (
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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titleChanges in the Distribution of HIV Type 1 Subtypes D and A in Rakai District, Uganda Between 1994 and 2002
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creatorConroy, Samantha A. ; Laeyendecker, Oliver ; Redd, Andrew D. ; Collinson-Streng, Aleisha ; Kong, Xiangrong ; Makumbi, Fredrick ; Lutalo, Tom ; Sewankambo, Nelson ; Kiwanuka, Noah ; Gray, Ronald H. ; Wawer, Maria J. ; Serwadda, David ; Quinn, Thomas C.
creatorcontribConroy, Samantha A. ; Laeyendecker, Oliver ; Redd, Andrew D. ; Collinson-Streng, Aleisha ; Kong, Xiangrong ; Makumbi, Fredrick ; Lutalo, Tom ; Sewankambo, Nelson ; Kiwanuka, Noah ; Gray, Ronald H. ; Wawer, Maria J. ; Serwadda, David ; Quinn, Thomas C. ; Rakai Health Sciences Program
descriptionHIV-1 subtype D (HIV-1D) progresses to disease faster and has lower transmissibility than subtype A (HIV-1A). We examined whether these differences could lead to a population level change in the distribution of these subtypes over time. HIV-1 viral RNA was extracted from stored serum samples from HIV-positive subjects participating in a population-based cohort study in Rakai, Uganda in 1994 and 2002. Portions of the viral proteins gag and gp41 were sequenced and subtyped. HIV-1 subtype assignments were generated for 773 subjects in 1994 and 812 subjects in 2002. The change in subtype distribution of the population as a whole as well as quartile age groups were examined for significant changes using a linear model. There was a significant decrease in the proportion of subjects infected with HIV-1D from 70.2% to 62.4% and a significant increase in subjects infected with HIV-1A from 16.7% to 23.3% over the 8-year period ( p  = 0.005). The most marked changes in proportion of HIV-1D and A were seen in the younger individuals (<25 and 25–30 years; p  < 0.05). The percentages of subjects infected with HIV-1C and recombinant subtypes did not change significantly. Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D.
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subjectAdolescent ; Adult ; AIDS/HIV ; Biological and medical sciences ; Cohort Studies ; Development and progression ; Diagnosis ; Disease transmission ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; gag Gene Products, Human Immunodeficiency Virus - genetics ; gag Gene Products, Human Immunodeficiency Virus - metabolism ; Genetic aspects ; HIV Envelope Protein gp41 - genetics ; HIV Envelope Protein gp41 - metabolism ; HIV infection ; HIV Infections - epidemiology ; HIV Infections - genetics ; HIV Infections - transmission ; HIV testing ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - pathogenicity ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Sequence Data ; Recombination, Genetic ; Retrovirus ; RNA Viruses - pathogenicity ; Rural Population ; Sequence Analysis, DNA ; Uganda - epidemiology ; Viral diseases ; Virology ; virus diseases ; Young Adult
ispartofAIDS research and human retroviruses, 2010, Vol.26 (10), p.187-1091
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7Sewankambo, Nelson
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0Changes in the Distribution of HIV Type 1 Subtypes D and A in Rakai District, Uganda Between 1994 and 2002
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descriptionHIV-1 subtype D (HIV-1D) progresses to disease faster and has lower transmissibility than subtype A (HIV-1A). We examined whether these differences could lead to a population level change in the distribution of these subtypes over time. HIV-1 viral RNA was extracted from stored serum samples from HIV-positive subjects participating in a population-based cohort study in Rakai, Uganda in 1994 and 2002. Portions of the viral proteins gag and gp41 were sequenced and subtyped. HIV-1 subtype assignments were generated for 773 subjects in 1994 and 812 subjects in 2002. The change in subtype distribution of the population as a whole as well as quartile age groups were examined for significant changes using a linear model. There was a significant decrease in the proportion of subjects infected with HIV-1D from 70.2% to 62.4% and a significant increase in subjects infected with HIV-1A from 16.7% to 23.3% over the 8-year period ( p  = 0.005). The most marked changes in proportion of HIV-1D and A were seen in the younger individuals (<25 and 25–30 years; p  < 0.05). The percentages of subjects infected with HIV-1C and recombinant subtypes did not change significantly. Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D.
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23Human immunodeficiency virus 1
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titleChanges in the Distribution of HIV Type 1 Subtypes D and A in Rakai District, Uganda Between 1994 and 2002
authorConroy, Samantha A. ; Laeyendecker, Oliver ; Redd, Andrew D. ; Collinson-Streng, Aleisha ; Kong, Xiangrong ; Makumbi, Fredrick ; Lutalo, Tom ; Sewankambo, Nelson ; Kiwanuka, Noah ; Gray, Ronald H. ; Wawer, Maria J. ; Serwadda, David ; Quinn, Thomas C.
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abstractHIV-1 subtype D (HIV-1D) progresses to disease faster and has lower transmissibility than subtype A (HIV-1A). We examined whether these differences could lead to a population level change in the distribution of these subtypes over time. HIV-1 viral RNA was extracted from stored serum samples from HIV-positive subjects participating in a population-based cohort study in Rakai, Uganda in 1994 and 2002. Portions of the viral proteins gag and gp41 were sequenced and subtyped. HIV-1 subtype assignments were generated for 773 subjects in 1994 and 812 subjects in 2002. The change in subtype distribution of the population as a whole as well as quartile age groups were examined for significant changes using a linear model. There was a significant decrease in the proportion of subjects infected with HIV-1D from 70.2% to 62.4% and a significant increase in subjects infected with HIV-1A from 16.7% to 23.3% over the 8-year period ( p  = 0.005). The most marked changes in proportion of HIV-1D and A were seen in the younger individuals (<25 and 25–30 years; p  < 0.05). The percentages of subjects infected with HIV-1C and recombinant subtypes did not change significantly. Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D.
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