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De Novo Myocardial Regeneration: Advances and Pitfalls

The capability of adult tissue-derived stem cells for cardiogenesis has been extensively studied in experimental animals and clinical studies for treatment of postischemic cardiomyopathy. The less-than-anticipated improvement in the heart function in most clinical studies with skeletal myoblasts and... Full description

Journal Title: Antioxidants & redox signaling 2010, Vol.13 (12), p.1867-1877
Main Author: Haider, Khawaja Husnain
Other Authors: Buccini, Stephanie , Ahmed, Rafeeq P.H. , Ashraf, Muhammad
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 1523-0864
Link: https://www.ncbi.nlm.nih.gov/pubmed/20695792
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2971636
title: De Novo Myocardial Regeneration: Advances and Pitfalls
format: Article
creator:
  • Haider, Khawaja Husnain
  • Buccini, Stephanie
  • Ahmed, Rafeeq P.H.
  • Ashraf, Muhammad
subjects:
  • Cardiomyopathies - therapy
  • Cell- and Tissue-Based Therapy - methods
  • Embryonic development
  • Embryonic stem cells
  • Embryonic Stem Cells - cytology
  • Forum Review
  • Forum Review Articles
  • Heart
  • Humans
  • Induced Pluripotent Stem Cells - cytology
  • Myocardium - cytology
  • Physiological aspects
  • Pluripotent Stem Cells - cytology
  • Stem Cell Transplantation
ispartof: Antioxidants & redox signaling, 2010, Vol.13 (12), p.1867-1877
description: The capability of adult tissue-derived stem cells for cardiogenesis has been extensively studied in experimental animals and clinical studies for treatment of postischemic cardiomyopathy. The less-than-anticipated improvement in the heart function in most clinical studies with skeletal myoblasts and bone marrow cells has warranted a search for alternative sources of stem cells. Despite their multilineage differentiation potential, ethical issues, teratogenicity, and tissue rejection are main obstacles in developing clinically feasible methods for embryonic stem cell transplantation into patients. A decade-long research on embryonic stem cells has paved the way for discovery of alternative approaches for generating pluripotent stem cells. Genetic manipulation of somatic cells for pluripotency genes reprograms the cells to pluripotent status. Efforts are currently focused to make reprogramming protocols safer for clinical applications of the reprogrammed cells. We summarize the advancements and complicating features of stem cell therapy and discuss the decade-and-a-half-long efforts made by stem cell researchers for moving the field from bench to the bedside as an adjunct therapy or as an alternative to the contemporary therapeutic modalities for routine clinical application. The review also provides a special focus on the advancements made in the field of somatic cell reprogramming. Antioxid. Redox Signal. 13, 1867–1877.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1523-0864
fulltext: fulltext
issn:
  • 1523-0864
  • 1557-7716
url: Link


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descriptionThe capability of adult tissue-derived stem cells for cardiogenesis has been extensively studied in experimental animals and clinical studies for treatment of postischemic cardiomyopathy. The less-than-anticipated improvement in the heart function in most clinical studies with skeletal myoblasts and bone marrow cells has warranted a search for alternative sources of stem cells. Despite their multilineage differentiation potential, ethical issues, teratogenicity, and tissue rejection are main obstacles in developing clinically feasible methods for embryonic stem cell transplantation into patients. A decade-long research on embryonic stem cells has paved the way for discovery of alternative approaches for generating pluripotent stem cells. Genetic manipulation of somatic cells for pluripotency genes reprograms the cells to pluripotent status. Efforts are currently focused to make reprogramming protocols safer for clinical applications of the reprogrammed cells. We summarize the advancements and complicating features of stem cell therapy and discuss the decade-and-a-half-long efforts made by stem cell researchers for moving the field from bench to the bedside as an adjunct therapy or as an alternative to the contemporary therapeutic modalities for routine clinical application. The review also provides a special focus on the advancements made in the field of somatic cell reprogramming. Antioxid. Redox Signal. 13, 1867–1877.
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subjectCardiomyopathies - therapy ; Cell- and Tissue-Based Therapy - methods ; Embryonic development ; Embryonic stem cells ; Embryonic Stem Cells - cytology ; Forum Review ; Forum Review Articles ; Heart ; Humans ; Induced Pluripotent Stem Cells - cytology ; Myocardium - cytology ; Physiological aspects ; Pluripotent Stem Cells - cytology ; Stem Cell Transplantation
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abstractThe capability of adult tissue-derived stem cells for cardiogenesis has been extensively studied in experimental animals and clinical studies for treatment of postischemic cardiomyopathy. The less-than-anticipated improvement in the heart function in most clinical studies with skeletal myoblasts and bone marrow cells has warranted a search for alternative sources of stem cells. Despite their multilineage differentiation potential, ethical issues, teratogenicity, and tissue rejection are main obstacles in developing clinically feasible methods for embryonic stem cell transplantation into patients. A decade-long research on embryonic stem cells has paved the way for discovery of alternative approaches for generating pluripotent stem cells. Genetic manipulation of somatic cells for pluripotency genes reprograms the cells to pluripotent status. Efforts are currently focused to make reprogramming protocols safer for clinical applications of the reprogrammed cells. We summarize the advancements and complicating features of stem cell therapy and discuss the decade-and-a-half-long efforts made by stem cell researchers for moving the field from bench to the bedside as an adjunct therapy or as an alternative to the contemporary therapeutic modalities for routine clinical application. The review also provides a special focus on the advancements made in the field of somatic cell reprogramming. Antioxid. Redox Signal. 13, 1867–1877.
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