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Multitargeted therapy of cancer by green tea polyphenols

Abstract Tea ranks second only to water as a major component of fluid intake worldwide and has been considered a health-promoting beverage since ancient times. For the past two decades, we and others have been investigating the potential cancer preventive and therapeutic effects of green tea and its... Full description

Journal Title: Cancer letters 2008, Vol.269 (2), p.269-280
Main Author: Khan, Naghma
Other Authors: Mukhtar, Hasan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Tea
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/18501505
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2996277
title: Multitargeted therapy of cancer by green tea polyphenols
format: Article
creator:
  • Khan, Naghma
  • Mukhtar, Hasan
subjects:
  • Anticarcinogenic Agents - pharmacology
  • Antioxidants
  • Apoptosis - drug effects
  • Article
  • beverages
  • Biological Availability
  • Breast cancer
  • Cancer
  • Care and treatment
  • Catechin
  • Catechin - analogs & derivatives
  • Catechin - pharmacokinetics
  • Catechin - pharmacology
  • Catechin - therapeutic use
  • Cell Cycle - drug effects
  • complex mixtures
  • EGCG
  • Flavonoids - pharmacokinetics
  • Flavonoids - pharmacology
  • Flavonoids - therapeutic use
  • food
  • Green tea
  • Green tea polyphenols
  • Health aspects
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Insulin-Like Growth Factor I - antagonists & inhibitors
  • MAP Kinase Signaling System - drug effects
  • Matrix Metalloproteinase Inhibitors
  • Neoplasms - drug therapy
  • NF-kappa B - antagonists & inhibitors
  • Phenols - pharmacokinetics
  • Phenols - pharmacology
  • Phenols - therapeutic use
  • Polyphenols
  • Receptor, Epidermal Growth Factor - antagonists & inhibitors
  • Rodents
  • Signal transduction
  • Signal Transduction - drug effects
  • Tea
  • Tea - chemistry
  • Transcription Factor AP-1 - antagonists & inhibitors
  • Urokinase-Type Plasminogen Activator - antagonists & inhibitors
ispartof: Cancer letters, 2008, Vol.269 (2), p.269-280
description: Abstract Tea ranks second only to water as a major component of fluid intake worldwide and has been considered a health-promoting beverage since ancient times. For the past two decades, we and others have been investigating the potential cancer preventive and therapeutic effects of green tea and its polyphenolic mixture termed GTP. It has become clear that much of these effects of GTP are mediated by its most abundant catechin, epigallocatechin gallate (EGCG). Large amount of encouraging data from in vitro and animal models has emerged making clear that green tea is a nature’s gift molecule endowed with anticancer effects. Epidemiological and geographical observations suggest that these laboratory data may be applicable to human population. Clinical trials of GTP, especially in prostate cancer patients have yielded encouraging results. This article briefly reviews properties of GTP, especially EGCG with reference to multitargeted therapy of cancer.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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descriptionAbstract Tea ranks second only to water as a major component of fluid intake worldwide and has been considered a health-promoting beverage since ancient times. For the past two decades, we and others have been investigating the potential cancer preventive and therapeutic effects of green tea and its polyphenolic mixture termed GTP. It has become clear that much of these effects of GTP are mediated by its most abundant catechin, epigallocatechin gallate (EGCG). Large amount of encouraging data from in vitro and animal models has emerged making clear that green tea is a nature’s gift molecule endowed with anticancer effects. Epidemiological and geographical observations suggest that these laboratory data may be applicable to human population. Clinical trials of GTP, especially in prostate cancer patients have yielded encouraging results. This article briefly reviews properties of GTP, especially EGCG with reference to multitargeted therapy of cancer.
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abstractAbstract Tea ranks second only to water as a major component of fluid intake worldwide and has been considered a health-promoting beverage since ancient times. For the past two decades, we and others have been investigating the potential cancer preventive and therapeutic effects of green tea and its polyphenolic mixture termed GTP. It has become clear that much of these effects of GTP are mediated by its most abundant catechin, epigallocatechin gallate (EGCG). Large amount of encouraging data from in vitro and animal models has emerged making clear that green tea is a nature’s gift molecule endowed with anticancer effects. Epidemiological and geographical observations suggest that these laboratory data may be applicable to human population. Clinical trials of GTP, especially in prostate cancer patients have yielded encouraging results. This article briefly reviews properties of GTP, especially EGCG with reference to multitargeted therapy of cancer.
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