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Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks

Notch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the... Full description

Journal Title: Neuron 2011-02-10, Vol.69 (3), p.437-444
Main Author: Alberi, Lavinia
Other Authors: Liu, Shuxi , Wang, Yue , Badie, Ramy , Smith-Hicks, Constance , Wu, Jing , Pierfelice, Tarran J , Abazyan, Bagrat , Mattson, Mark P , Kuhl, Dietmar , Pletnikov, Mikhail , Worley, Paul F , Gaiano, Nicholas
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
Link: https://www.ncbi.nlm.nih.gov/pubmed/21315255
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3056341
title: Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks
format: Article
creator:
  • Alberi, Lavinia
  • Liu, Shuxi
  • Wang, Yue
  • Badie, Ramy
  • Smith-Hicks, Constance
  • Wu, Jing
  • Pierfelice, Tarran J
  • Abazyan, Bagrat
  • Mattson, Mark P
  • Kuhl, Dietmar
  • Pletnikov, Mikhail
  • Worley, Paul F
  • Gaiano, Nicholas
subjects:
  • Animals
  • Article
  • Cells, Cultured
  • Cytoskeletal Proteins - physiology
  • Depression, Mental
  • Hippocampus - physiology
  • Maze Learning - physiology
  • Medical colleges
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Neurologic Mutants
  • Nerve Net - physiology
  • Nerve Tissue Proteins - physiology
  • Neuronal Plasticity - physiology
  • Neurons
  • Neurons - physiology
  • Neuroscience(all)
  • Neurosciences
  • Receptor, Notch1 - physiology
  • Signal Transduction - physiology
  • Synapses - physiology
ispartof: Neuron, 2011-02-10, Vol.69 (3), p.437-444
description: Notch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation. ► Notch1 is essential for synaptic plasticity, learning, and short-term memory ► Notch receptor activation occurs in neurons in response to neuronal activity ► Activity-induced neuronal Notch1 expression and signaling is dependent upon Arc ► Arc-dependent neuronal Notch signaling occurs in the hippocampus after exploration
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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titleActivity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks
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creatorAlberi, Lavinia ; Liu, Shuxi ; Wang, Yue ; Badie, Ramy ; Smith-Hicks, Constance ; Wu, Jing ; Pierfelice, Tarran J ; Abazyan, Bagrat ; Mattson, Mark P ; Kuhl, Dietmar ; Pletnikov, Mikhail ; Worley, Paul F ; Gaiano, Nicholas
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descriptionNotch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation. ► Notch1 is essential for synaptic plasticity, learning, and short-term memory ► Notch receptor activation occurs in neurons in response to neuronal activity ► Activity-induced neuronal Notch1 expression and signaling is dependent upon Arc ► Arc-dependent neuronal Notch signaling occurs in the hippocampus after exploration
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subjectAnimals ; Article ; Cells, Cultured ; Cytoskeletal Proteins - physiology ; Depression, Mental ; Hippocampus - physiology ; Maze Learning - physiology ; Medical colleges ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Neurologic Mutants ; Nerve Net - physiology ; Nerve Tissue Proteins - physiology ; Neuronal Plasticity - physiology ; Neurons ; Neurons - physiology ; Neuroscience(all) ; Neurosciences ; Receptor, Notch1 - physiology ; Signal Transduction - physiology ; Synapses - physiology
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descriptionNotch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation. ► Notch1 is essential for synaptic plasticity, learning, and short-term memory ► Notch receptor activation occurs in neurons in response to neuronal activity ► Activity-induced neuronal Notch1 expression and signaling is dependent upon Arc ► Arc-dependent neuronal Notch signaling occurs in the hippocampus after exploration
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titleActivity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks
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abstractNotch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also regulates neuronal morphology, synaptic plasticity, learning, and memory. Here we show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mutant neurons, the proteolytic activation of Notch1 is disrupted both in vivo and in vitro. Conditional deletion of Notch1 in the postnatal hippocampus disrupted both long-term potentiation (LTP) and long-term depression (LTD), and led to deficits in learning and short-term memory. Thus, Notch signaling is dynamically regulated in response to neuronal activity, Arc/Arg3.1 is a context-dependent Notch regulator, and Notch1 is required for the synaptic plasticity that contributes to memory formation. ► Notch1 is essential for synaptic plasticity, learning, and short-term memory ► Notch receptor activation occurs in neurons in response to neuronal activity ► Activity-induced neuronal Notch1 expression and signaling is dependent upon Arc ► Arc-dependent neuronal Notch signaling occurs in the hippocampus after exploration
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pmid21315255
doi10.1016/j.neuron.2011.01.004
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