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A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis

Abstract Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant... Full description

Journal Title: Vaccine 2011, Vol.29 (15), p.2803-2809
Main Author: Wang, Danher
Other Authors: Suhrbier, Andreas , Penn-Nicholson, Adam , Woraratanadharm, Jan , Gardner, Joy , Luo, Min , Le, Thuy T , Anraku, Itaru , Sakalian, Michael , Einfeld, David , Dong, John Y
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0264-410X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3061842
title: A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis
format: Article
creator:
  • Wang, Danher
  • Suhrbier, Andreas
  • Penn-Nicholson, Adam
  • Woraratanadharm, Jan
  • Gardner, Joy
  • Luo, Min
  • Le, Thuy T
  • Anraku, Itaru
  • Sakalian, Michael
  • Einfeld, David
  • Dong, John Y
subjects:
  • Adenoviridae - genetics
  • Adenovirus
  • Adenoviruses
  • Allergy and Immunology
  • Alphavirus Infections - immunology
  • Alphavirus Infections - prevention & control
  • Animals
  • Antibodies, Viral - blood
  • Applied microbiology
  • Arthritis
  • Arthritis - immunology
  • Arthritis - prevention & control
  • Article
  • Biological and medical sciences
  • Chikungunya
  • Chikungunya virus - genetics
  • Chikungunya virus - immunology
  • Drug Carriers
  • Drug dosages
  • Ebola virus
  • Female
  • Fever
  • Fundamental and applied biological sciences. Psychology
  • Genetic Vectors
  • Genomes
  • Mice
  • Mice, Inbred C57BL
  • Microbiology
  • Miscellaneous
  • Monkeys & apes
  • Mortality
  • Mosquitoes
  • parasitic diseases
  • Rheumatic diseases
  • Technological change
  • Vaccination - methods
  • Vaccine
  • Vaccines
  • Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
  • Vaccines, Synthetic - administration & dosage
  • Vaccines, Synthetic - immunology
  • Viral Vaccines - administration & dosage
  • Viral Vaccines - immunology
  • Viremia - immunology
  • Viremia - prevention & control
  • Virology
  • Virus diseases
  • Viruses
ispartof: Vaccine, 2011, Vol.29 (15), p.2803-2809
description: Abstract Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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descriptionAbstract Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.
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descriptionAbstract Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.
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3Allergy and Immunology
4Alphavirus Infections - immunology
5Alphavirus Infections - prevention & control
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40Vaccines, Synthetic - immunology
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42Viral Vaccines - immunology
43Viremia - immunology
44Viremia - prevention & control
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46Virus diseases
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titleA complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis
authorWang, Danher ; Suhrbier, Andreas ; Penn-Nicholson, Adam ; Woraratanadharm, Jan ; Gardner, Joy ; Luo, Min ; Le, Thuy T ; Anraku, Itaru ; Sakalian, Michael ; Einfeld, David ; Dong, John Y
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abstractAbstract Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.
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pmid21320541
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