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Pancreatic cancer

Summary Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cance... Full description

Journal Title: The Lancet (British edition) 2011, Vol.378 (9791), p.607-620
Main Author: Vincent, Audrey, PhD
Other Authors: Herman, Joseph, Prof , Schulick, Rich, Prof , Hruban, Ralph H, Prof , Goggins, Michael, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0140-6736
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3062508
title: Pancreatic cancer
format: Article
creator:
  • Vincent, Audrey, PhD
  • Herman, Joseph, Prof
  • Schulick, Rich, Prof
  • Hruban, Ralph H, Prof
  • Goggins, Michael, Prof
subjects:
  • Abridged Index Medicus
  • Article
  • Biological and medical sciences
  • Carcinoma, Pancreatic Ductal - diagnosis
  • Carcinoma, Pancreatic Ductal - genetics
  • Carcinoma, Pancreatic Ductal - pathology
  • Carcinoma, Pancreatic Ductal - therapy
  • Care and treatment
  • Development and progression
  • Diagnosis
  • Family medical history
  • Gastroenterology. Liver. Pancreas. Abdomen
  • General aspects
  • Genetics
  • Health aspects
  • Humans
  • Internal Medicine
  • Liver. Biliary tract. Portal circulation. Exocrine pancreas
  • Medical sciences
  • Mutation
  • Pancreas
  • Pancreatectomy
  • Pancreatic cancer
  • Pancreatic Neoplasms - diagnosis
  • Pancreatic Neoplasms - genetics
  • Pancreatic Neoplasms - pathology
  • Pancreatic Neoplasms - therapy
  • Risk Factors
  • Tumors
ispartof: The Lancet (British edition), 2011, Vol.378 (9791), p.607-620
description: Summary Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant disease. The incidence of and number of deaths caused by pancreatic tumours have been gradually rising, even as incidence and mortality of other common cancers have been declining. Despite developments in detection and management of pancreatic cancer, only about 4% of patients will live 5 years after diagnosis. Survival is better for those with malignant disease localised to the pancreas, because surgical resection at present offers the only chance of cure. Unfortunately, 80–85% of patients present with advanced unresectable disease. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionSummary Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant disease. The incidence of and number of deaths caused by pancreatic tumours have been gradually rising, even as incidence and mortality of other common cancers have been declining. Despite developments in detection and management of pancreatic cancer, only about 4% of patients will live 5 years after diagnosis. Survival is better for those with malignant disease localised to the pancreas, because surgical resection at present offers the only chance of cure. Unfortunately, 80–85% of patients present with advanced unresectable disease. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma.
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subjectAbridged Index Medicus ; Article ; Biological and medical sciences ; Carcinoma, Pancreatic Ductal - diagnosis ; Carcinoma, Pancreatic Ductal - genetics ; Carcinoma, Pancreatic Ductal - pathology ; Carcinoma, Pancreatic Ductal - therapy ; Care and treatment ; Development and progression ; Diagnosis ; Family medical history ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Genetics ; Health aspects ; Humans ; Internal Medicine ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mutation ; Pancreas ; Pancreatectomy ; Pancreatic cancer ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - therapy ; Risk Factors ; Tumors
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descriptionSummary Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant disease. The incidence of and number of deaths caused by pancreatic tumours have been gradually rising, even as incidence and mortality of other common cancers have been declining. Despite developments in detection and management of pancreatic cancer, only about 4% of patients will live 5 years after diagnosis. Survival is better for those with malignant disease localised to the pancreas, because surgical resection at present offers the only chance of cure. Unfortunately, 80–85% of patients present with advanced unresectable disease. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma.
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22Pancreatic cancer
23Pancreatic Neoplasms - diagnosis
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abstractSummary Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant disease. The incidence of and number of deaths caused by pancreatic tumours have been gradually rising, even as incidence and mortality of other common cancers have been declining. Despite developments in detection and management of pancreatic cancer, only about 4% of patients will live 5 years after diagnosis. Survival is better for those with malignant disease localised to the pancreas, because surgical resection at present offers the only chance of cure. Unfortunately, 80–85% of patients present with advanced unresectable disease. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma.
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