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The Specificity of Nitroxyl Chemistry Is Unique Among Nitrogen Oxides in Biological Systems

The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in s... Full description

Journal Title: ANTIOXIDANTS & REDOX SIGNALING 2011, Vol.14 (9), p.1659-1674
Main Author: Flores-Santana, Wilmarie
Other Authors: Salmon, Debra J. , Donzelli, Sonia , Switzer, Christopher H. , Basudhar, Debashree , Ridnour, Lisa , Cheng, Robert , Glynn, Sharon A. , Paolocci, Nazareno , Fukuto, Jon M. , Miranda, Katrina M. , Wink, David A.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Mary Ann Liebert, Inc
ID: ISSN: 1523-0864
Link: https://www.ncbi.nlm.nih.gov/pubmed/21235346
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title: The Specificity of Nitroxyl Chemistry Is Unique Among Nitrogen Oxides in Biological Systems
format: Article
creator:
  • Flores-Santana, Wilmarie
  • Salmon, Debra J.
  • Donzelli, Sonia
  • Switzer, Christopher H.
  • Basudhar, Debashree
  • Ridnour, Lisa
  • Cheng, Robert
  • Glynn, Sharon A.
  • Paolocci, Nazareno
  • Fukuto, Jon M.
  • Miranda, Katrina M.
  • Wink, David A.
subjects:
  • Animals
  • Chemical properties
  • Forum Review
  • Forum Review Articles
  • Health aspects
  • Humans
  • Metalloproteins - chemistry
  • Metalloproteins - metabolism
  • Nitrogen oxide
  • Nitrogen Oxides - chemistry
  • Nitrogen Oxides - metabolism
  • Oxidation-reduction reaction
  • Sulfhydryl Compounds - chemistry
  • Sulfhydryl Compounds - metabolism
  • Thiols
ispartof: ANTIOXIDANTS & REDOX SIGNALING, 2011, Vol.14 (9), p.1659-1674
description: The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review. Antioxid. Redox Signal. 14, 1659–1674.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1523-0864
fulltext: fulltext
issn:
  • 1523-0864
  • 1557-7716
url: Link


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descriptionThe importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review. Antioxid. Redox Signal. 14, 1659–1674.
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subjectAnimals ; Chemical properties ; Forum Review ; Forum Review Articles ; Health aspects ; Humans ; Metalloproteins - chemistry ; Metalloproteins - metabolism ; Nitrogen oxide ; Nitrogen Oxides - chemistry ; Nitrogen Oxides - metabolism ; Oxidation-reduction reaction ; Sulfhydryl Compounds - chemistry ; Sulfhydryl Compounds - metabolism ; Thiols
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abstractThe importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review. Antioxid. Redox Signal. 14, 1659–1674.
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