schliessen

Filtern

 

Bibliotheken

Cover Image

Magnetic nanoparticle biodistribution following intratumoral administration

Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be det... Full description

Journal Title: Nanotechnology 2011-08-26, Vol.22 (34), p.345101-1-5
Main Author: Giustini, A J
Other Authors: Ivkov, R , Hoopes, P J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adenocarcinoma - therapy
Animals
Article
biodistribution
breast adenocarcinoma
Breast Neoplasms - therapy
Cancer
Dextrans - chemistry
Female
Ferric Compounds - administration & dosage
Ferric Compounds - pharmacokinetics
Ferric Compounds - therapeutic use
Humans
Iron oxides
magnetic nanoparticle
Mice
Nanomaterials
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - analysis
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Nanostructure
TEM
Tissue Distribution
Transmission electron microscopy
tumor
Tumors
Uptakes
Quelle: Alma/SFX Local Collection
Publisher: England
ID: ISSN: 0957-4484
Link: https://www.ncbi.nlm.nih.gov/pubmed/21795772
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3158492
title: Magnetic nanoparticle biodistribution following intratumoral administration
format: Article
creator:
  • Giustini, A J
  • Ivkov, R
  • Hoopes, P J
subjects:
  • Adenocarcinoma - therapy
  • Animals
  • Article
  • biodistribution
  • breast adenocarcinoma
  • Breast Neoplasms - therapy
  • Cancer
  • Dextrans - chemistry
  • Female
  • Ferric Compounds - administration & dosage
  • Ferric Compounds - pharmacokinetics
  • Ferric Compounds - therapeutic use
  • Humans
  • Iron oxides
  • magnetic nanoparticle
  • Mice
  • Nanomaterials
  • Nanoparticles
  • Nanoparticles - administration & dosage
  • Nanoparticles - analysis
  • Nanoparticles - chemistry
  • Nanoparticles - therapeutic use
  • Nanostructure
  • TEM
  • Tissue Distribution
  • Transmission electron microscopy
  • tumor
  • Tumors
  • Uptakes
ispartof: Nanotechnology, 2011-08-26, Vol.22 (34), p.345101-1-5
description: Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0957-4484
fulltext: fulltext
issn:
  • 0957-4484
  • 1361-6528
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.550045
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_pubme
recordidTN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3158492
sourceformatXML
sourcesystemPC
sourcerecordid1019657851
originalsourceidFETCH-LOGICAL-1511t-ae2a8bc9dea572f7f49253167ed7559aa37fe0d8400d1cdaf3c2fa0347ef722d3
addsrcrecordideNqFkU9v1DAQxS0EokvhK1Q5ctmuZxzHiYSQUAUtoogLnK2J_yxGib04SRHfHoctK8oFyZItzZs3b_xj7AL4JfC23fFOqm1dt_UOcSfqciRweMQ2IBrYNhLbx2xzEp2xZ9P0jXOAFuEpO0NQpaRwwz58pH10czBVpJgOlMtzcFUfkg3TnEO_zCHFyqdhSD9C3FchzpnmZUyZhorsGOKqo1X1nD3xNEzuxf19zr68e_v56mZ7--n6_dWb2y1IgHlLDqntTWcdSYVe-bpDKaBRziopOyKhvOO2rTm3YCx5YdATF7VyXiFacc5eH30PSz86a9waadCHHEbKP3WioB9WYviq9-lOC5BtGVYMbo4G6eAihewe9NryHzpZjY3SPUoyDrqu6QQ3BolbFMa4ugEsIX2xenmfJafvi5tmPYbJuGGg6NIy6QKla6RqJRRpc5SanKYpO3-aClyvUPXKS6-8NKIWtT5CLY0Xf-97avtDsQhe_eNswvwbSVk_DP_z_wUrxbK8
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1019657851
display
typearticle
titleMagnetic nanoparticle biodistribution following intratumoral administration
sourceAlma/SFX Local Collection
creatorGiustini, A J ; Ivkov, R ; Hoopes, P J
creatorcontribGiustini, A J ; Ivkov, R ; Hoopes, P J
descriptionRecently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
identifier
0ISSN: 0957-4484
1EISSN: 1361-6528
2DOI: 10.1088/0957-4484/22/34/345101
3PMID: 21795772
languageeng
publisherEngland
subjectAdenocarcinoma - therapy ; Animals ; Article ; biodistribution ; breast adenocarcinoma ; Breast Neoplasms - therapy ; Cancer ; Dextrans - chemistry ; Female ; Ferric Compounds - administration & dosage ; Ferric Compounds - pharmacokinetics ; Ferric Compounds - therapeutic use ; Humans ; Iron oxides ; magnetic nanoparticle ; Mice ; Nanomaterials ; Nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - analysis ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanostructure ; TEM ; Tissue Distribution ; Transmission electron microscopy ; tumor ; Tumors ; Uptakes
ispartofNanotechnology, 2011-08-26, Vol.22 (34), p.345101-1-5
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1511t-ae2a8bc9dea572f7f49253167ed7559aa37fe0d8400d1cdaf3c2fa0347ef722d3
citesFETCH-LOGICAL-1511t-ae2a8bc9dea572f7f49253167ed7559aa37fe0d8400d1cdaf3c2fa0347ef722d3
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21795772$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Giustini, A J
1Ivkov, R
2Hoopes, P J
title
0Magnetic nanoparticle biodistribution following intratumoral administration
1Nanotechnology
addtitleNanotechnology
descriptionRecently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
subject
0Adenocarcinoma - therapy
1Animals
2Article
3biodistribution
4breast adenocarcinoma
5Breast Neoplasms - therapy
6Cancer
7Dextrans - chemistry
8Female
9Ferric Compounds - administration & dosage
10Ferric Compounds - pharmacokinetics
11Ferric Compounds - therapeutic use
12Humans
13Iron oxides
14magnetic nanoparticle
15Mice
16Nanomaterials
17Nanoparticles
18Nanoparticles - administration & dosage
19Nanoparticles - analysis
20Nanoparticles - chemistry
21Nanoparticles - therapeutic use
22Nanostructure
23TEM
24Tissue Distribution
25Transmission electron microscopy
26tumor
27Tumors
28Uptakes
issn
00957-4484
11361-6528
fulltexttrue
rsrctypearticle
creationdate2011
recordtypearticle
recordideNqFkU9v1DAQxS0EokvhK1Q5ctmuZxzHiYSQUAUtoogLnK2J_yxGib04SRHfHoctK8oFyZItzZs3b_xj7AL4JfC23fFOqm1dt_UOcSfqciRweMQ2IBrYNhLbx2xzEp2xZ9P0jXOAFuEpO0NQpaRwwz58pH10czBVpJgOlMtzcFUfkg3TnEO_zCHFyqdhSD9C3FchzpnmZUyZhorsGOKqo1X1nD3xNEzuxf19zr68e_v56mZ7--n6_dWb2y1IgHlLDqntTWcdSYVe-bpDKaBRziopOyKhvOO2rTm3YCx5YdATF7VyXiFacc5eH30PSz86a9waadCHHEbKP3WioB9WYviq9-lOC5BtGVYMbo4G6eAihewe9NryHzpZjY3SPUoyDrqu6QQ3BolbFMa4ugEsIX2xenmfJafvi5tmPYbJuGGg6NIy6QKla6RqJRRpc5SanKYpO3-aClyvUPXKS6-8NKIWtT5CLY0Xf-97avtDsQhe_eNswvwbSVk_DP_z_wUrxbK8
startdate20110826
enddate20110826
creator
0Giustini, A J
1Ivkov, R
2Hoopes, P J
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
87SR
97U5
108BQ
118FD
12F28
13FR3
14JG9
15L7M
16BOBZL
17CLFQK
185PM
sort
creationdate20110826
titleMagnetic nanoparticle biodistribution following intratumoral administration
authorGiustini, A J ; Ivkov, R ; Hoopes, P J
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1511t-ae2a8bc9dea572f7f49253167ed7559aa37fe0d8400d1cdaf3c2fa0347ef722d3
rsrctypearticles
prefilterarticles
languageeng
creationdate2011
topic
0Adenocarcinoma - therapy
1Animals
2Article
3biodistribution
4breast adenocarcinoma
5Breast Neoplasms - therapy
6Cancer
7Dextrans - chemistry
8Female
9Ferric Compounds - administration & dosage
10Ferric Compounds - pharmacokinetics
11Ferric Compounds - therapeutic use
12Humans
13Iron oxides
14magnetic nanoparticle
15Mice
16Nanomaterials
17Nanoparticles
18Nanoparticles - administration & dosage
19Nanoparticles - analysis
20Nanoparticles - chemistry
21Nanoparticles - therapeutic use
22Nanostructure
23TEM
24Tissue Distribution
25Transmission electron microscopy
26tumor
27Tumors
28Uptakes
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Giustini, A J
1Ivkov, R
2Hoopes, P J
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Engineered Materials Abstracts
8Solid State and Superconductivity Abstracts
9METADEX
10Technology Research Database
11ANTE: Abstracts in New Technology & Engineering
12Engineering Research Database
13Materials Research Database
14Advanced Technologies Database with Aerospace
15OpenAIRE (Open Access)
16OpenAIRE
17PubMed Central (Full Participant titles)
jtitleNanotechnology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Giustini, A J
1Ivkov, R
2Hoopes, P J
formatjournal
genrearticle
ristypeJOUR
atitleMagnetic nanoparticle biodistribution following intratumoral administration
jtitleNanotechnology
addtitleNanotechnology
date2011-08-26
risdate2011
volume22
issue34
spage345101
epage1-5
pages345101-1-5
issn0957-4484
eissn1361-6528
notesCurrent address: Dept. of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231-5678
abstractRecently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
copEngland
pmid21795772
doi10.1088/0957-4484/22/34/345101
oafree_for_read