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Magnetic nanoparticle biodistribution following intratumoral administration

Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be det... Full description

Journal Title: Nanotechnology 2011-08-26, Vol.22 (34), p.345101-1-5
Main Author: Giustini, A J
Other Authors: Ivkov, R , Hoopes, P J
Format: Electronic Article Electronic Article
Language: English
Subjects:
TEM
Quelle: Alma/SFX Local Collection
Publisher: England
ID: ISSN: 0957-4484
Link: https://www.ncbi.nlm.nih.gov/pubmed/21795772
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3158492
title: Magnetic nanoparticle biodistribution following intratumoral administration
format: Article
creator:
  • Giustini, A J
  • Ivkov, R
  • Hoopes, P J
subjects:
  • Adenocarcinoma - therapy
  • Animals
  • Article
  • biodistribution
  • breast adenocarcinoma
  • Breast Neoplasms - therapy
  • Cancer
  • Dextrans - chemistry
  • Female
  • Ferric Compounds - administration & dosage
  • Ferric Compounds - pharmacokinetics
  • Ferric Compounds - therapeutic use
  • Humans
  • Iron oxides
  • magnetic nanoparticle
  • Mice
  • Nanomaterials
  • Nanoparticles
  • Nanoparticles - administration & dosage
  • Nanoparticles - analysis
  • Nanoparticles - chemistry
  • Nanoparticles - therapeutic use
  • Nanostructure
  • TEM
  • Tissue Distribution
  • Transmission electron microscopy
  • tumor
  • Tumors
  • Uptakes
ispartof: Nanotechnology, 2011-08-26, Vol.22 (34), p.345101-1-5
description: Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0957-4484
fulltext: fulltext
issn:
  • 0957-4484
  • 1361-6528
url: Link


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descriptionRecently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
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subjectAdenocarcinoma - therapy ; Animals ; Article ; biodistribution ; breast adenocarcinoma ; Breast Neoplasms - therapy ; Cancer ; Dextrans - chemistry ; Female ; Ferric Compounds - administration & dosage ; Ferric Compounds - pharmacokinetics ; Ferric Compounds - therapeutic use ; Humans ; Iron oxides ; magnetic nanoparticle ; Mice ; Nanomaterials ; Nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - analysis ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanostructure ; TEM ; Tissue Distribution ; Transmission electron microscopy ; tumor ; Tumors ; Uptakes
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abstractRecently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130 nm in a murine breast adenocarcinoma cell line (MTG-B) in vivo. Tumors averaging volumes of 115 mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120 h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4 h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.
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