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Molecular Epidemiology of HIV Type 1 in Singapore and Identification of Novel CRF01_AE/B Recombinant Forms

To investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (... Full description

Journal Title: AIDS research and human retroviruses 2011, Vol.27 (10), p.1135-1137
Main Author: Ng, Oon Tek
Other Authors: Munshaw, Supriya , Lamers, Susanna L. , Chew, Kuan Kiat , Lin, Li , Redd, Andrew D. , Manucci, Jordyn , Quinn, Thomas C. , Ray, Stuart C. , Chua, Arlene , Leo, Yee Sin , Laeyendecker, Oliver
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New Rochelle, NY: Mary Ann Liebert, Inc
ID: ISSN: 0889-2229
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title: Molecular Epidemiology of HIV Type 1 in Singapore and Identification of Novel CRF01_AE/B Recombinant Forms
format: Article
creator:
  • Ng, Oon Tek
  • Munshaw, Supriya
  • Lamers, Susanna L.
  • Chew, Kuan Kiat
  • Lin, Li
  • Redd, Andrew D.
  • Manucci, Jordyn
  • Quinn, Thomas C.
  • Ray, Stuart C.
  • Chua, Arlene
  • Leo, Yee Sin
  • Laeyendecker, Oliver
subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • AIDS/HIV
  • Base Sequence
  • Biological and medical sciences
  • Cross-Sectional Studies
  • Disease transmission
  • Epidemiology
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Genetic aspects
  • HIV (Viruses)
  • HIV Envelope Protein gp120 - genetics
  • HIV Envelope Protein gp41 - genetics
  • HIV Infections - epidemiology
  • HIV Infections - virology
  • HIV-1 - classification
  • HIV-1 - genetics
  • HIV-1 - isolation & purification
  • HIV-1 - pathogenicity
  • Human immunodeficiency virus 1
  • Human viral diseases
  • Humans
  • Infectious diseases
  • Male
  • Medical sciences
  • Microbiology
  • Middle Aged
  • Miscellaneous
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Phylogeny
  • pol Gene Products, Human Immunodeficiency Virus - genetics
  • Retrovirus
  • Risk Factors
  • RNA, Viral - blood
  • RNA, Viral - genetics
  • Sequence Notes
  • Singapore - epidemiology
  • Viral diseases
  • Virology
  • virus diseases
  • viruses
  • Young Adult
ispartof: AIDS research and human retroviruses, 2011, Vol.27 (10), p.1135-1137
description: To investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (51.4%) generated interpretable data in all regions. Sixty-one (56.0%) were identified as CRF01_AE, 26 (23.9%) as subtype B and 14 (12.8%) as possible novel recombinant forms. The main novel recombinant pattern, detected in 13 sequences, had subtype B in protease and gp41 and CRF01_AE in gp120. There was intermixing of subtypes within transmission risk groups. However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B ( p  = 0.001).
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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descriptionTo investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (51.4%) generated interpretable data in all regions. Sixty-one (56.0%) were identified as CRF01_AE, 26 (23.9%) as subtype B and 14 (12.8%) as possible novel recombinant forms. The main novel recombinant pattern, detected in 13 sequences, had subtype B in protease and gp41 and CRF01_AE in gp120. There was intermixing of subtypes within transmission risk groups. However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B ( p  = 0.001).
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subjectAdolescent ; Adult ; Aged ; Aged, 80 and over ; AIDS/HIV ; Base Sequence ; Biological and medical sciences ; Cross-Sectional Studies ; Disease transmission ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; HIV (Viruses) ; HIV Envelope Protein gp120 - genetics ; HIV Envelope Protein gp41 - genetics ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - isolation & purification ; HIV-1 - pathogenicity ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Epidemiology ; Molecular Sequence Data ; Phylogeny ; pol Gene Products, Human Immunodeficiency Virus - genetics ; Retrovirus ; Risk Factors ; RNA, Viral - blood ; RNA, Viral - genetics ; Sequence Notes ; Singapore - epidemiology ; Viral diseases ; Virology ; virus diseases ; viruses ; Young Adult
ispartofAIDS research and human retroviruses, 2011, Vol.27 (10), p.1135-1137
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descriptionTo investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (51.4%) generated interpretable data in all regions. Sixty-one (56.0%) were identified as CRF01_AE, 26 (23.9%) as subtype B and 14 (12.8%) as possible novel recombinant forms. The main novel recombinant pattern, detected in 13 sequences, had subtype B in protease and gp41 and CRF01_AE in gp120. There was intermixing of subtypes within transmission risk groups. However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B ( p  = 0.001).
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15HIV Envelope Protein gp41 - genetics
16HIV Infections - epidemiology
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titleMolecular Epidemiology of HIV Type 1 in Singapore and Identification of Novel CRF01_AE/B Recombinant Forms
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abstractTo investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (51.4%) generated interpretable data in all regions. Sixty-one (56.0%) were identified as CRF01_AE, 26 (23.9%) as subtype B and 14 (12.8%) as possible novel recombinant forms. The main novel recombinant pattern, detected in 13 sequences, had subtype B in protease and gp41 and CRF01_AE in gp120. There was intermixing of subtypes within transmission risk groups. However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B ( p  = 0.001).
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