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Prognostic value of resection of primary tumor in patients with stage IV colorectal cancer: retrospective analysis of two randomized studies and a review of the literature

In patients with metastatic colorectal cancer (mCRC) with an asymptomatic primary tumor, there is no consensus on the indication for resection of the primary tumor. A retrospective analysis was performed on the outcome of stage IV colorectal cancer (CRC) patients with or without resection of the pri... Full description

Journal Title: Annals of Surgical Oncology 2011, Vol.18 (12), p.3252-3260
Main Author: Venderbosch, Sabine
Other Authors: de Wilt, Johannes H , Teerenstra, Steven , Loosveld, Olaf J , van Bochove, Aart , Sinnige, Harm A , Creemers, Geert-Jan M , Tesselaar, Margot E , Mol, Linda , Punt, Cornelis J. A , Koopman, Miriam
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York: Springer-Verlag
ID: ISSN: 1068-9265
Link: https://www.ncbi.nlm.nih.gov/pubmed/21822557
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3192274
title: Prognostic value of resection of primary tumor in patients with stage IV colorectal cancer: retrospective analysis of two randomized studies and a review of the literature
format: Article
creator:
  • Venderbosch, Sabine
  • de Wilt, Johannes H
  • Teerenstra, Steven
  • Loosveld, Olaf J
  • van Bochove, Aart
  • Sinnige, Harm A
  • Creemers, Geert-Jan M
  • Tesselaar, Margot E
  • Mol, Linda
  • Punt, Cornelis J. A
  • Koopman, Miriam
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis
  • Biometry
  • Cancer
  • Cancer patients
  • Care and treatment
  • Clinical Trials, Phase III as Topic
  • Colorectal Cancer
  • Colorectal Neoplasms - mortality
  • Colorectal Neoplasms - pathology
  • Colorectal Neoplasms - surgery
  • Female
  • Humans
  • Male
  • Medicine
  • Medicine & Public Health
  • Metastasis
  • Middle Aged
  • Neoplasm Staging
  • Oncology
  • Oncology, Experimental
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Retrospective Studies
  • Review Literature as Topic
  • Surgery
  • Surgical Oncology
  • Survival Rate
ispartof: Annals of Surgical Oncology, 2011, Vol.18 (12), p.3252-3260
description: In patients with metastatic colorectal cancer (mCRC) with an asymptomatic primary tumor, there is no consensus on the indication for resection of the primary tumor. A retrospective analysis was performed on the outcome of stage IV colorectal cancer (CRC) patients with or without resection of the primary tumor treated in the phase III CAIRO and CAIRO2 studies. A review of the literature was performed. In the CAIRO and CAIRO2 studies, 258 and 289 patients had undergone a primary tumor resection and 141 and 159 patients had not, respectively. In the CAIRO study, a significantly better median overall survival and progression-free survival was observed for the resection compared to the nonresection group, with 16.7 vs. 11.4 months [P
language: eng
source:
identifier: ISSN: 1068-9265
fulltext: no_fulltext
issn:
  • 1068-9265
  • 1534-4681
url: Link


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titlePrognostic value of resection of primary tumor in patients with stage IV colorectal cancer: retrospective analysis of two randomized studies and a review of the literature
creatorVenderbosch, Sabine ; de Wilt, Johannes H ; Teerenstra, Steven ; Loosveld, Olaf J ; van Bochove, Aart ; Sinnige, Harm A ; Creemers, Geert-Jan M ; Tesselaar, Margot E ; Mol, Linda ; Punt, Cornelis J. A ; Koopman, Miriam
creatorcontribVenderbosch, Sabine ; de Wilt, Johannes H ; Teerenstra, Steven ; Loosveld, Olaf J ; van Bochove, Aart ; Sinnige, Harm A ; Creemers, Geert-Jan M ; Tesselaar, Margot E ; Mol, Linda ; Punt, Cornelis J. A ; Koopman, Miriam
descriptionIn patients with metastatic colorectal cancer (mCRC) with an asymptomatic primary tumor, there is no consensus on the indication for resection of the primary tumor. A retrospective analysis was performed on the outcome of stage IV colorectal cancer (CRC) patients with or without resection of the primary tumor treated in the phase III CAIRO and CAIRO2 studies. A review of the literature was performed. In the CAIRO and CAIRO2 studies, 258 and 289 patients had undergone a primary tumor resection and 141 and 159 patients had not, respectively. In the CAIRO study, a significantly better median overall survival and progression-free survival was observed for the resection compared to the nonresection group, with 16.7 vs. 11.4 months [P <0.0001, hazard ratio (HR) 0.61], and 6.7 vs. 5.9 months (P=0.004; HR 0.74), respectively. In the CAIRO2 study, median overall survival and progression-free survival were also significantly better for the resection compared to the nonresection group, with 20.7 vs. 13.4 months (P <0.0001; HR 0.65) and 10.5 vs. 7.8 months (P=0.014; HR 0.78), respectively. These differences remained significant in multivariate analyses. Our review identified 22 nonrandomized studies, most of which showed improved survival for mCRC patients who underwent resection of the primary tumor. Our results as well as data from literature indicate that resection of the primary tumor is a prognostic factor for survival in stage IV CRC patients. The potential bias of these results warrants prospective studies on the value of resection of primary tumor in this setting; such studies are currently being planned
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subjectAdult ; Aged ; Aged, 80 and over ; Analysis ; Biometry ; Cancer ; Cancer patients ; Care and treatment ; Clinical Trials, Phase III as Topic ; Colorectal Cancer ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoplasm Staging ; Oncology ; Oncology, Experimental ; Prognosis ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Review Literature as Topic ; Surgery ; Surgical Oncology ; Survival Rate
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descriptionIn patients with metastatic colorectal cancer (mCRC) with an asymptomatic primary tumor, there is no consensus on the indication for resection of the primary tumor. A retrospective analysis was performed on the outcome of stage IV colorectal cancer (CRC) patients with or without resection of the primary tumor treated in the phase III CAIRO and CAIRO2 studies. A review of the literature was performed. In the CAIRO and CAIRO2 studies, 258 and 289 patients had undergone a primary tumor resection and 141 and 159 patients had not, respectively. In the CAIRO study, a significantly better median overall survival and progression-free survival was observed for the resection compared to the nonresection group, with 16.7 vs. 11.4 months [P <0.0001, hazard ratio (HR) 0.61], and 6.7 vs. 5.9 months (P=0.004; HR 0.74), respectively. In the CAIRO2 study, median overall survival and progression-free survival were also significantly better for the resection compared to the nonresection group, with 20.7 vs. 13.4 months (P <0.0001; HR 0.65) and 10.5 vs. 7.8 months (P=0.014; HR 0.78), respectively. These differences remained significant in multivariate analyses. Our review identified 22 nonrandomized studies, most of which showed improved survival for mCRC patients who underwent resection of the primary tumor. Our results as well as data from literature indicate that resection of the primary tumor is a prognostic factor for survival in stage IV CRC patients. The potential bias of these results warrants prospective studies on the value of resection of primary tumor in this setting; such studies are currently being planned
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titlePrognostic value of resection of primary tumor in patients with stage IV colorectal cancer: retrospective analysis of two randomized studies and a review of the literature
authorVenderbosch, Sabine ; de Wilt, Johannes H ; Teerenstra, Steven ; Loosveld, Olaf J ; van Bochove, Aart ; Sinnige, Harm A ; Creemers, Geert-Jan M ; Tesselaar, Margot E ; Mol, Linda ; Punt, Cornelis J. A ; Koopman, Miriam
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23Prognosis
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25Retrospective Studies
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7Tesselaar, Margot E
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atitlePrognostic value of resection of primary tumor in patients with stage IV colorectal cancer: retrospective analysis of two randomized studies and a review of the literature
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issn1068-9265
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abstractIn patients with metastatic colorectal cancer (mCRC) with an asymptomatic primary tumor, there is no consensus on the indication for resection of the primary tumor. A retrospective analysis was performed on the outcome of stage IV colorectal cancer (CRC) patients with or without resection of the primary tumor treated in the phase III CAIRO and CAIRO2 studies. A review of the literature was performed. In the CAIRO and CAIRO2 studies, 258 and 289 patients had undergone a primary tumor resection and 141 and 159 patients had not, respectively. In the CAIRO study, a significantly better median overall survival and progression-free survival was observed for the resection compared to the nonresection group, with 16.7 vs. 11.4 months [P <0.0001, hazard ratio (HR) 0.61], and 6.7 vs. 5.9 months (P=0.004; HR 0.74), respectively. In the CAIRO2 study, median overall survival and progression-free survival were also significantly better for the resection compared to the nonresection group, with 20.7 vs. 13.4 months (P <0.0001; HR 0.65) and 10.5 vs. 7.8 months (P=0.014; HR 0.78), respectively. These differences remained significant in multivariate analyses. Our review identified 22 nonrandomized studies, most of which showed improved survival for mCRC patients who underwent resection of the primary tumor. Our results as well as data from literature indicate that resection of the primary tumor is a prognostic factor for survival in stage IV CRC patients. The potential bias of these results warrants prospective studies on the value of resection of primary tumor in this setting; such studies are currently being planned
copNew York
pubSpringer-Verlag
pmid21822557
doi10.1245/s10434-011-1951-5
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