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Periodontitis and diabetes: a two-way relationship

Periodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly prevalent (severe periodontitis affects 10–15% of adults) and has multiple negative impacts on quality of life. Epi... Full description

Journal Title: Diabetologia 2011, Vol.55 (1), p.21-31
Main Author: Preshaw, P. M
Other Authors: Alba, A. L , Herrera, D , Jepsen, S , Konstantinidis, A , Makrilakis, K , Taylor, R
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3228943
title: Periodontitis and diabetes: a two-way relationship
format: Article
creator:
  • Preshaw, P. M
  • Alba, A. L
  • Herrera, D
  • Jepsen, S
  • Konstantinidis, A
  • Makrilakis, K
  • Taylor, R
subjects:
  • Animals
  • Biological and medical sciences
  • Chronic kidney failure
  • Diabetes
  • Diabetes complications
  • Diabetes Mellitus, Type 1 - complications
  • Diabetes Mellitus, Type 1 - immunology
  • Diabetes Mellitus, Type 1 - microbiology
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - immunology
  • Diabetes Mellitus, Type 2 - microbiology
  • Diabetes. Impaired glucose tolerance
  • Diabetics
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinology
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Facial bones, jaws, teeth, parodontium: diseases, semeiology
  • Health aspects
  • Heart diseases
  • Human Physiology
  • Humans
  • Hyperglycemia
  • Internal Medicine
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Metabolism
  • Non tumoral diseases
  • Otorhinolaryngology. Stomatology
  • Periodontal diseases
  • Periodontitis
  • Periodontitis - complications
  • Periodontitis - epidemiology
  • Periodontitis - immunology
  • Periodontitis - microbiology
  • Review
  • Risk Factors
  • Type 1 diabetes mellitus
  • Type 2 diabetes mellitus
ispartof: Diabetologia, 2011, Vol.55 (1), p.21-31
description: Periodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly prevalent (severe periodontitis affects 10–15% of adults) and has multiple negative impacts on quality of life. Epidemiological data confirm that diabetes is a major risk factor for periodontitis; susceptibility to periodontitis is increased by approximately threefold in people with diabetes. There is a clear relationship between degree of hyperglycaemia and severity of periodontitis. The mechanisms that underpin the links between these two conditions are not completely understood, but involve aspects of immune functioning, neutrophil activity, and cytokine biology. There is emerging evidence to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycaemic control. Incidences of macroalbuminuria and end-stage renal disease are increased twofold and threefold, respectively, in diabetic individuals who also have severe periodontitis compared to diabetic individuals without severe periodontitis. Furthermore, the risk of cardiorenal mortality (ischaemic heart disease and diabetic nephropathy combined) is three times higher in diabetic people with severe periodontitis than in diabetic people without severe periodontitis. Treatment of periodontitis is associated with HbA 1c reductions of approximately 0.4%. Oral and periodontal health should be promoted as integral components of diabetes management.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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descriptionPeriodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly prevalent (severe periodontitis affects 10–15% of adults) and has multiple negative impacts on quality of life. Epidemiological data confirm that diabetes is a major risk factor for periodontitis; susceptibility to periodontitis is increased by approximately threefold in people with diabetes. There is a clear relationship between degree of hyperglycaemia and severity of periodontitis. The mechanisms that underpin the links between these two conditions are not completely understood, but involve aspects of immune functioning, neutrophil activity, and cytokine biology. There is emerging evidence to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycaemic control. Incidences of macroalbuminuria and end-stage renal disease are increased twofold and threefold, respectively, in diabetic individuals who also have severe periodontitis compared to diabetic individuals without severe periodontitis. Furthermore, the risk of cardiorenal mortality (ischaemic heart disease and diabetic nephropathy combined) is three times higher in diabetic people with severe periodontitis than in diabetic people without severe periodontitis. Treatment of periodontitis is associated with HbA 1c reductions of approximately 0.4%. Oral and periodontal health should be promoted as integral components of diabetes management.
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subjectAnimals ; Biological and medical sciences ; Chronic kidney failure ; Diabetes ; Diabetes complications ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - microbiology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - immunology ; Diabetes Mellitus, Type 2 - microbiology ; Diabetes. Impaired glucose tolerance ; Diabetics ; Endocrine pancreas. Apud cells (diseases) ; Endocrinology ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Health aspects ; Heart diseases ; Human Physiology ; Humans ; Hyperglycemia ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Periodontal diseases ; Periodontitis ; Periodontitis - complications ; Periodontitis - epidemiology ; Periodontitis - immunology ; Periodontitis - microbiology ; Review ; Risk Factors ; Type 1 diabetes mellitus ; Type 2 diabetes mellitus
ispartofDiabetologia, 2011, Vol.55 (1), p.21-31
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1Alba, A. L
2Herrera, D
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descriptionPeriodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly prevalent (severe periodontitis affects 10–15% of adults) and has multiple negative impacts on quality of life. Epidemiological data confirm that diabetes is a major risk factor for periodontitis; susceptibility to periodontitis is increased by approximately threefold in people with diabetes. There is a clear relationship between degree of hyperglycaemia and severity of periodontitis. The mechanisms that underpin the links between these two conditions are not completely understood, but involve aspects of immune functioning, neutrophil activity, and cytokine biology. There is emerging evidence to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycaemic control. Incidences of macroalbuminuria and end-stage renal disease are increased twofold and threefold, respectively, in diabetic individuals who also have severe periodontitis compared to diabetic individuals without severe periodontitis. Furthermore, the risk of cardiorenal mortality (ischaemic heart disease and diabetic nephropathy combined) is three times higher in diabetic people with severe periodontitis than in diabetic people without severe periodontitis. Treatment of periodontitis is associated with HbA 1c reductions of approximately 0.4%. Oral and periodontal health should be promoted as integral components of diabetes management.
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0Animals
1Biological and medical sciences
2Chronic kidney failure
3Diabetes
4Diabetes complications
5Diabetes Mellitus, Type 1 - complications
6Diabetes Mellitus, Type 1 - immunology
7Diabetes Mellitus, Type 1 - microbiology
8Diabetes Mellitus, Type 2 - complications
9Diabetes Mellitus, Type 2 - immunology
10Diabetes Mellitus, Type 2 - microbiology
11Diabetes. Impaired glucose tolerance
12Diabetics
13Endocrine pancreas. Apud cells (diseases)
14Endocrinology
15Endocrinopathies
16Etiopathogenesis. Screening. Investigations. Target tissue resistance
17Facial bones, jaws, teeth, parodontium: diseases, semeiology
18Health aspects
19Heart diseases
20Human Physiology
21Humans
22Hyperglycemia
23Internal Medicine
24Medical sciences
25Medicine
26Medicine & Public Health
27Metabolic Diseases
28Metabolism
29Non tumoral diseases
30Otorhinolaryngology. Stomatology
31Periodontal diseases
32Periodontitis
33Periodontitis - complications
34Periodontitis - epidemiology
35Periodontitis - immunology
36Periodontitis - microbiology
37Review
38Risk Factors
39Type 1 diabetes mellitus
40Type 2 diabetes mellitus
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0Animals
1Biological and medical sciences
2Chronic kidney failure
3Diabetes
4Diabetes complications
5Diabetes Mellitus, Type 1 - complications
6Diabetes Mellitus, Type 1 - immunology
7Diabetes Mellitus, Type 1 - microbiology
8Diabetes Mellitus, Type 2 - complications
9Diabetes Mellitus, Type 2 - immunology
10Diabetes Mellitus, Type 2 - microbiology
11Diabetes. Impaired glucose tolerance
12Diabetics
13Endocrine pancreas. Apud cells (diseases)
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15Endocrinopathies
16Etiopathogenesis. Screening. Investigations. Target tissue resistance
17Facial bones, jaws, teeth, parodontium: diseases, semeiology
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20Human Physiology
21Humans
22Hyperglycemia
23Internal Medicine
24Medical sciences
25Medicine
26Medicine & Public Health
27Metabolic Diseases
28Metabolism
29Non tumoral diseases
30Otorhinolaryngology. Stomatology
31Periodontal diseases
32Periodontitis
33Periodontitis - complications
34Periodontitis - epidemiology
35Periodontitis - immunology
36Periodontitis - microbiology
37Review
38Risk Factors
39Type 1 diabetes mellitus
40Type 2 diabetes mellitus
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abstractPeriodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly prevalent (severe periodontitis affects 10–15% of adults) and has multiple negative impacts on quality of life. Epidemiological data confirm that diabetes is a major risk factor for periodontitis; susceptibility to periodontitis is increased by approximately threefold in people with diabetes. There is a clear relationship between degree of hyperglycaemia and severity of periodontitis. The mechanisms that underpin the links between these two conditions are not completely understood, but involve aspects of immune functioning, neutrophil activity, and cytokine biology. There is emerging evidence to support the existence of a two-way relationship between diabetes and periodontitis, with diabetes increasing the risk for periodontitis, and periodontal inflammation negatively affecting glycaemic control. Incidences of macroalbuminuria and end-stage renal disease are increased twofold and threefold, respectively, in diabetic individuals who also have severe periodontitis compared to diabetic individuals without severe periodontitis. Furthermore, the risk of cardiorenal mortality (ischaemic heart disease and diabetic nephropathy combined) is three times higher in diabetic people with severe periodontitis than in diabetic people without severe periodontitis. Treatment of periodontitis is associated with HbA 1c reductions of approximately 0.4%. Oral and periodontal health should be promoted as integral components of diabetes management.
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pubSpringer-Verlag
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doi10.1007/s00125-011-2342-y
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