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Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study

BackgroundType 2 diabetes has been inconsistently associated with the risk of atrial fibrillation (AF) in previous studies that have frequently been beset by methodological challenges.DesignProspective cohort study.SettingThe Atherosclerosis Risk in Communities (ARIC) study.ParticipantsDetailed medi... Full description

Journal Title: Heart (British Cardiac Society) 2012, Vol.98 (2), p.133-138
Main Author: Huxley, Rachel R
Other Authors: Alonso, Alvaro , Lopez, Faye L , Filion, Kristian B , Agarwal, Sunil K , Loehr, Laura R , Soliman, Elsayed Z , Pankow, James S , Selvin, Elizabeth
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 1355-6037
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3237721
title: Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study
format: Article
creator:
  • Huxley, Rachel R
  • Alonso, Alvaro
  • Lopez, Faye L
  • Filion, Kristian B
  • Agarwal, Sunil K
  • Loehr, Laura R
  • Soliman, Elsayed Z
  • Pankow, James S
  • Selvin, Elizabeth
subjects:
  • Abridged Index Medicus
  • arrhythmias
  • Article
  • Atherosclerosis
  • Atherosclerosis (general aspects, experimental research)
  • Atrial fibrillation
  • Atrial Fibrillation - epidemiology
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Blood Glucose
  • brugada
  • Cardiac arrhythmia
  • Cardiac dysrhythmias
  • Cardiology. Vascular system
  • Cardiovascular disease
  • Cohort analysis
  • Diabetes
  • Diabetes Mellitus, Type 2 - blood
  • Diabetes Mellitus, Type 2 - epidemiology
  • Diabetes Mellitus, Type 2 - metabolism
  • Diabetes. Impaired glucose tolerance
  • Diagnosis
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • epidemiology
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fasting
  • Female
  • Health aspects
  • Health risk assessment
  • Heart
  • heart rate variability
  • Homeostasis
  • Humans
  • Insulin
  • Insulin resistance
  • macrovascular disease
  • Male
  • Medical sciences
  • metabolic medicine
  • Middle Aged
  • QT interval
  • Risk Assessment
  • Risk Factors
  • Sample size
  • smoking
  • sudden cardiac death
  • Surveillance
  • Type 2 diabetes
  • Usage
ispartof: Heart (British Cardiac Society), 2012, Vol.98 (2), p.133-138
description: BackgroundType 2 diabetes has been inconsistently associated with the risk of atrial fibrillation (AF) in previous studies that have frequently been beset by methodological challenges.DesignProspective cohort study.SettingThe Atherosclerosis Risk in Communities (ARIC) study.ParticipantsDetailed medical histories were obtained from 13 025 participants. Individuals were categorised as having no diabetes, pre-diabetes or diabetes based on the 2010 American Diabetes Association criteria at study baseline (1990–2).Main outcome measuresDiagnoses of incident AF were obtained to the end of 2007. Associations between type 2 diabetes and markers of glucose homeostasis and the incidence of AF were estimated using Cox proportional hazards models after adjusting for possible confounders.ResultsType 2 diabetes was associated with a significant increase in the risk of AF (HR 1.35, 95% CI 1.14 to 1.60) after adjustment for confounders. There was no indication that individuals with pre-diabetes or those with undiagnosed diabetes were at increased risk of AF compared with those without diabetes. A positive linear association was observed between HbA1c and the risk of AF in those with and without diabetes (HR 1.13, 95% CI 1.07 to 1.20) and HR 1.05, 95% CI 0.96 to 1.15 per 1% point increase, respectively). There was no association between fasting glucose or insulin in those without diabetes, but a significant association with fasting glucose was found in those with the condition. The results were similar in white subjects and African-Americans.ConclusionsDiabetes, HbA1c level and poor glycaemic control are independently associated with an increased risk of AF, but the underlying mechanisms governing the relationship are unknown and warrant further investigation.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


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titleType 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study
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creatorHuxley, Rachel R ; Alonso, Alvaro ; Lopez, Faye L ; Filion, Kristian B ; Agarwal, Sunil K ; Loehr, Laura R ; Soliman, Elsayed Z ; Pankow, James S ; Selvin, Elizabeth
creatorcontribHuxley, Rachel R ; Alonso, Alvaro ; Lopez, Faye L ; Filion, Kristian B ; Agarwal, Sunil K ; Loehr, Laura R ; Soliman, Elsayed Z ; Pankow, James S ; Selvin, Elizabeth
descriptionBackgroundType 2 diabetes has been inconsistently associated with the risk of atrial fibrillation (AF) in previous studies that have frequently been beset by methodological challenges.DesignProspective cohort study.SettingThe Atherosclerosis Risk in Communities (ARIC) study.ParticipantsDetailed medical histories were obtained from 13 025 participants. Individuals were categorised as having no diabetes, pre-diabetes or diabetes based on the 2010 American Diabetes Association criteria at study baseline (1990–2).Main outcome measuresDiagnoses of incident AF were obtained to the end of 2007. Associations between type 2 diabetes and markers of glucose homeostasis and the incidence of AF were estimated using Cox proportional hazards models after adjusting for possible confounders.ResultsType 2 diabetes was associated with a significant increase in the risk of AF (HR 1.35, 95% CI 1.14 to 1.60) after adjustment for confounders. There was no indication that individuals with pre-diabetes or those with undiagnosed diabetes were at increased risk of AF compared with those without diabetes. A positive linear association was observed between HbA1c and the risk of AF in those with and without diabetes (HR 1.13, 95% CI 1.07 to 1.20) and HR 1.05, 95% CI 0.96 to 1.15 per 1% point increase, respectively). There was no association between fasting glucose or insulin in those without diabetes, but a significant association with fasting glucose was found in those with the condition. The results were similar in white subjects and African-Americans.ConclusionsDiabetes, HbA1c level and poor glycaemic control are independently associated with an increased risk of AF, but the underlying mechanisms governing the relationship are unknown and warrant further investigation.
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subjectAbridged Index Medicus ; arrhythmias ; Article ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Atrial fibrillation ; Atrial Fibrillation - epidemiology ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose ; brugada ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Cardiovascular disease ; Cohort analysis ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Diagnosis ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fasting ; Female ; Health aspects ; Health risk assessment ; Heart ; heart rate variability ; Homeostasis ; Humans ; Insulin ; Insulin resistance ; macrovascular disease ; Male ; Medical sciences ; metabolic medicine ; Middle Aged ; QT interval ; Risk Assessment ; Risk Factors ; Sample size ; smoking ; sudden cardiac death ; Surveillance ; Type 2 diabetes ; Usage
ispartofHeart (British Cardiac Society), 2012, Vol.98 (2), p.133-138
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02011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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7Pankow, James S
8Selvin, Elizabeth
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1Heart (British Cardiac Society)
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descriptionBackgroundType 2 diabetes has been inconsistently associated with the risk of atrial fibrillation (AF) in previous studies that have frequently been beset by methodological challenges.DesignProspective cohort study.SettingThe Atherosclerosis Risk in Communities (ARIC) study.ParticipantsDetailed medical histories were obtained from 13 025 participants. Individuals were categorised as having no diabetes, pre-diabetes or diabetes based on the 2010 American Diabetes Association criteria at study baseline (1990–2).Main outcome measuresDiagnoses of incident AF were obtained to the end of 2007. Associations between type 2 diabetes and markers of glucose homeostasis and the incidence of AF were estimated using Cox proportional hazards models after adjusting for possible confounders.ResultsType 2 diabetes was associated with a significant increase in the risk of AF (HR 1.35, 95% CI 1.14 to 1.60) after adjustment for confounders. There was no indication that individuals with pre-diabetes or those with undiagnosed diabetes were at increased risk of AF compared with those without diabetes. A positive linear association was observed between HbA1c and the risk of AF in those with and without diabetes (HR 1.13, 95% CI 1.07 to 1.20) and HR 1.05, 95% CI 0.96 to 1.15 per 1% point increase, respectively). There was no association between fasting glucose or insulin in those without diabetes, but a significant association with fasting glucose was found in those with the condition. The results were similar in white subjects and African-Americans.ConclusionsDiabetes, HbA1c level and poor glycaemic control are independently associated with an increased risk of AF, but the underlying mechanisms governing the relationship are unknown and warrant further investigation.
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28Health aspects
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34Insulin
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37Male
38Medical sciences
39metabolic medicine
40Middle Aged
41QT interval
42Risk Assessment
43Risk Factors
44Sample size
45smoking
46sudden cardiac death
47Surveillance
48Type 2 diabetes
49Usage
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titleType 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study
authorHuxley, Rachel R ; Alonso, Alvaro ; Lopez, Faye L ; Filion, Kristian B ; Agarwal, Sunil K ; Loehr, Laura R ; Soliman, Elsayed Z ; Pankow, James S ; Selvin, Elizabeth
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7Biological and medical sciences
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abstractBackgroundType 2 diabetes has been inconsistently associated with the risk of atrial fibrillation (AF) in previous studies that have frequently been beset by methodological challenges.DesignProspective cohort study.SettingThe Atherosclerosis Risk in Communities (ARIC) study.ParticipantsDetailed medical histories were obtained from 13 025 participants. Individuals were categorised as having no diabetes, pre-diabetes or diabetes based on the 2010 American Diabetes Association criteria at study baseline (1990–2).Main outcome measuresDiagnoses of incident AF were obtained to the end of 2007. Associations between type 2 diabetes and markers of glucose homeostasis and the incidence of AF were estimated using Cox proportional hazards models after adjusting for possible confounders.ResultsType 2 diabetes was associated with a significant increase in the risk of AF (HR 1.35, 95% CI 1.14 to 1.60) after adjustment for confounders. There was no indication that individuals with pre-diabetes or those with undiagnosed diabetes were at increased risk of AF compared with those without diabetes. A positive linear association was observed between HbA1c and the risk of AF in those with and without diabetes (HR 1.13, 95% CI 1.07 to 1.20) and HR 1.05, 95% CI 0.96 to 1.15 per 1% point increase, respectively). There was no association between fasting glucose or insulin in those without diabetes, but a significant association with fasting glucose was found in those with the condition. The results were similar in white subjects and African-Americans.ConclusionsDiabetes, HbA1c level and poor glycaemic control are independently associated with an increased risk of AF, but the underlying mechanisms governing the relationship are unknown and warrant further investigation.
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