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Focus and breadth of cellular immune responses elicited by a heterologous insert prime-boost vaccine regimen in rhesus monkeys

Highlights ► A heterologous insert HIV-1 Gag prime-boost regimen was evaluated in rhesus monkeys. ► No improvement in cellular immune breadth or coverage was observed. ► Similar patterns of responses were induced by homologous and heterologous inserts.

Journal Title: Vaccine 2011, Vol.30 (3), p.506-509
Main Author: Kaufman, David R
Other Authors: Li, Fusheng , Cruz, Ashley N , Self, Steven G , Barouch, Dan H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/22133509
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title: Focus and breadth of cellular immune responses elicited by a heterologous insert prime-boost vaccine regimen in rhesus monkeys
format: Article
creator:
  • Kaufman, David R
  • Li, Fusheng
  • Cruz, Ashley N
  • Self, Steven G
  • Barouch, Dan H
subjects:
  • Acquired immune deficiency syndrome
  • Adenoviridae - genetics
  • Adenovirus
  • Adenoviruses
  • AIDS
  • AIDS Vaccines - immunology
  • Allergy and Immunology
  • Animals
  • Article
  • Cellular immune responses
  • Clinical trials
  • Epitopes - immunology
  • gag Gene Products, Human Immunodeficiency Virus - genetics
  • gag Gene Products, Human Immunodeficiency Virus - immunology
  • Genetic Variation
  • Genetic Vectors
  • Heterologous insert
  • HIV (Viruses)
  • HIV-1
  • HIV-1 - genetics
  • HIV-1 - immunology
  • Human immunodeficiency virus 1
  • Immune response
  • Immune system
  • Immunity, Cellular
  • Lymphocytes - immunology
  • Macaca mulatta
  • Monkeys
  • Peptides
  • Studies
  • Vaccination - methods
  • Vaccines
  • Vaccines, Synthetic - administration & dosage
  • Vaccines, Synthetic - immunology
ispartof: Vaccine, 2011, Vol.30 (3), p.506-509
description: Highlights ► A heterologous insert HIV-1 Gag prime-boost regimen was evaluated in rhesus monkeys. ► No improvement in cellular immune breadth or coverage was observed. ► Similar patterns of responses were induced by homologous and heterologous inserts.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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descriptionHighlights ► A heterologous insert HIV-1 Gag prime-boost regimen was evaluated in rhesus monkeys. ► No improvement in cellular immune breadth or coverage was observed. ► Similar patterns of responses were induced by homologous and heterologous inserts.
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subjectAcquired immune deficiency syndrome ; Adenoviridae - genetics ; Adenovirus ; Adenoviruses ; AIDS ; AIDS Vaccines - immunology ; Allergy and Immunology ; Animals ; Article ; Cellular immune responses ; Clinical trials ; Epitopes - immunology ; gag Gene Products, Human Immunodeficiency Virus - genetics ; gag Gene Products, Human Immunodeficiency Virus - immunology ; Genetic Variation ; Genetic Vectors ; Heterologous insert ; HIV (Viruses) ; HIV-1 ; HIV-1 - genetics ; HIV-1 - immunology ; Human immunodeficiency virus 1 ; Immune response ; Immune system ; Immunity, Cellular ; Lymphocytes - immunology ; Macaca mulatta ; Monkeys ; Peptides ; Studies ; Vaccination - methods ; Vaccines ; Vaccines, Synthetic - administration & dosage ; Vaccines, Synthetic - immunology
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abstractHighlights ► A heterologous insert HIV-1 Gag prime-boost regimen was evaluated in rhesus monkeys. ► No improvement in cellular immune breadth or coverage was observed. ► Similar patterns of responses were induced by homologous and heterologous inserts.
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